Zobrazeno 1 - 10 of 104 pro vyhledávání: '"Annette R Khaled"'
1
Akademický článek
Chaperonin containing TCP1 as a marker for identification of circulating tumor cells in blood.
Autor: Amanda Cox, Ana Martini, Heba Ghozlan, Rebecca Moroose, Xiang Zhu, Eunkyung Lee, Amr S Khaled, Louis Barr, Carlos Alemany, Na'im Fanaian, Elizabeth Griffith, Ryan Sause, S A Litherland, Annette R Khaled
Publikováno v: PLoS ONE, Vol 17, Iss 6, p e0264651 (2022)
Herein we report the use of Chaperonin-Containing TCP-1 (CCT or TRiC) as a marker to detect circulating tumor cells (CTCs) that are shed from tumors during oncogenesis. Most detection methods used in liquid biopsy approaches for enumeration of CTCs f
Externí odkaz: https://doaj.org/article/dc1dd0aa85834c73b0b242631d9dba77
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2
Akademický článek
JunD/AP-1-mediated gene expression promotes lymphocyte growth dependent on interleukin-7 signal transduction.
Autor: Shannon M Ruppert, Mounir Chehtane, Ge Zhang, Haiyan Hu, Xiaoman Li, Annette R Khaled
Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32262 (2012)
Interleukin-7 (IL-7) is an essential cytokine for lymphocyte growth that has the potential for promoting immune reconstitution. This feature makes IL-7 an ideal candidate for therapeutic development. As with other cytokines, signaling through the IL-
Externí odkaz: https://doaj.org/article/c80f56dbdfab4f7bb28a246362680e80
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3
Akademický článek
A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss
Autor: Fei Wei, Zewen Kelvin Tuong, Mahmoud Omer, Christopher Ngo, Jackson Asiatico, Michael Kinzel, Abinaya Sindu Pugazhendhi, Annette R. Khaled, Ranajay Ghosh, Melanie Coathup
Publikováno v: Bone Research, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Radiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone. Presently, no effective countermeasure exists, and ionizing radiation-induced
Externí odkaz: https://doaj.org/article/2ffa6119c43a4f82aef976b9f0573ead
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5
Akademický článek
The TRiCky Business of Protein Folding in Health and Disease
Autor: Heba Ghozlan, Amanda Cox, Daniel Nierenberg, Stephen King, Annette R. Khaled
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Maintenance of the cellular proteome or proteostasis is an essential process that when deregulated leads to diseases like neurological disorders and cancer. Central to proteostasis are the molecular chaperones that fold proteins into functional 3-dim
Externí odkaz: https://doaj.org/article/52288da60eef492cbd50815caba58ac6
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6
Akademický článek
Macromolecules Absorbed from Influenza Infection-Based Sera Modulate the Cellular Uptake of Polymeric Nanoparticles
Autor: Daniel Nierenberg, Orielyz Flores, David Fox, Yuen Yee Li Sip, Caroline M. Finn, Heba Ghozlan, Amanda Cox, Melanie Coathup, Karl Kai McKinstry, Lei Zhai, Annette R. Khaled
Publikováno v: Biomimetics, Vol 7, Iss 4, p 219 (2022)
Optimizing the biological identity of nanoparticles (NPs) for efficient tumor uptake remains challenging. The controlled formation of a protein corona on NPs through protein absorption from biofluids could favor a biological identity that enables tum
Externí odkaz: https://doaj.org/article/14948fc2c5f841329c43e0ba2b9cbce6
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7
Akademický článek
Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators
Autor: Heba Ghozlan, Adrian Showalter, Eunkyung Lee, Xiang Zhu, Annette R. Khaled
Publikováno v: Frontiers in Oncology, Vol 11 (2021)
Uncontrolled proliferation as a result of dysregulated cell cycling is one of the hallmarks of cancer. Therapeutically targeting pathways that control the cell cycle would improve patient outcomes. However, the development of drug resistance and a li
Externí odkaz: https://doaj.org/article/f89bf346212a4bac85efd5b5fd299707
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