Cellular fatty acid synthase is required for late stages of HIV-1 replication

Autor: Manjusha M. Kulkarni, Annette N. Ratcliff, Menakshi Bhat, Yazan Alwarawrah, Philip Hughes, Jesus Arcos, David Loiselle, Jordi B. Torrelles, Nicholas T. Funderburg, Timothy A. Haystead, Jesse J. Kwiek

Publikováno v: Retrovirology, Vol 14, Iss 1, Pp 1-12 (2017)

Abstract Background Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, pur

Externí odkaz: https://doaj.org/article/198c703fa7b643ab9fcf74aba658487f

Enhancement of CD4 Binding, Host Cell Entry, and Sensitivity to CD4bs Antibody Inhibition Conferred by a Natural but Rare Polymorphism in the HIV-1 Envelope

Autor: Annette N. Ratcliff, Colin M. Venner, Abayomi S. Olabode, Jason Knapp, Joshua Pankrac, Iulian Derecichei, Richard M. Gibson, Andrés Finzi, Yue Li, Jamie F. S. Mann, Eric J. Arts

Publikováno v: J Virol

A rare but natural polymorphism in the HIV-1 envelope (Env) glycoprotein, lysine at position 425 was selected as a mutation conferring resistance to maraviroc (MVC) in vitro. N425K has not been identified in HIV-infected individuals failing an MVC-ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab1f17028aebd2278ccde8f8db016f2
https://doi.org/10.1128/jvi.01851-21

Cellular fatty acid synthase is required for late stages of HIV-1 replication

Autor: David R. Loiselle, Jesus Arcos, Annette N. Ratcliff, Timothy A.J. Haystead, Menakshi Bhat, Nicholas T. Funderburg, Jesse J. Kwiek, Philip F. Hughes, Yazan Alwarawrah, Manjusha Kulkarni, Jordi B. Torrelles

Publikováno v: Retrovirology, Vol 14, Iss 1, Pp 1-12 (2017)
Retrovirology

Background Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1880c14a4eaea998a2f37ab77515b59e
http://link.springer.com/article/10.1186/s12977-017-0368-z

HIV-1 Group O Genotypes and Phenotypes: Relationship to Fitness and Susceptibility to Antiretroviral Drugs

Autor: Denis M. Tebit, Hamish Patel, Jean-Christophe Plantier, Annette N. Ratcliff, Joseph Liu, Eric J. Arts, Crystal Carpenter, Elodie Alessandri

Publikováno v: AIDS Research and Human Retroviruses
AIDS Research and Human Retroviruses, Mary Ann Liebert, 2016, 32 (7), pp.676-688. ⟨10.1089/aid.2015.0318⟩

Despite only 30,000 group O HIV-1 infections, a similar genetic diversity is observed among the O subgroups H (head) and T (tail) (previously described as subtypes A, B) as in the 9 group M subtypes (A-K). Group O isolates bearing a cysteine at rever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2c3bd18fd8c01f0e97a408f8f7a72
https://europepmc.org/articles/PMC4931737/

HIV-1 Entry, Inhibitors, and Resistance

Autor: Annette N. Ratcliff, Eric J. Arts, Michael A. Lobritz

Publikováno v: Viruses, Vol 2, Iss 5, Pp 1069-1105 (2010)
Viruses

Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dbe6967723f9fc9f553d87725239db
http://www.mdpi.com/1999-4915/2/5/1069/