A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer

Autor: Laoighse Mulrane, René Bernards, William M. Gallagher, Aisling O'Connor, Lisa Dwane, Brenton Cavanagh, Annette M.G. Dirac, Brian Mooney, Elspeth Ward, Benedikt M. Kessler, Anna M. Blümel, Adan Pinto-Fernandez, Karin Jirström, Triona Ni Chonghaile, Bruce Moran, Darran P. O'Connor, Sudipto Das

Publikováno v: Cancer Research. 80:5076-5088

Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c574e185effc9574bd8dc1ce179332d2
https://doi.org/10.1158/0008-5472.can-20-0214

A genomic and functional inventory of deubiquitinating enzymes

Autor: Annette M.G. Dirac, Titia K. Sixma, Mark P.A. Luna-Vargas, Arno Velds, René Bernards, Thijn R. Brummelkamp, Sebastian M.B. Nijman

Publikováno v: Cell, 123, 773. Elsevier

SummaryPosttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5623b5a67af74954fce0d2eb1a1da83f
https://ora.ox.ac.uk/objects/uuid:d290f643-2234-4694-a5f5-f31597a37e38

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

Autor: Juan Sahuquillo, Laura Rodon, René Bernards, Alba Gonzalez-Junca, José Baselga, Elena Martínez-Sáez, Annette M.G. Dirac, Joan Seoane, David Garcia-Dorado, Pieter Johan Adam Eichhorn, Magui Gili, Claudia Aura, Vicente Peg, Ignasi Barba, Aleix Prat, Isabel Cuartas, Jose Jimenez

Publikováno v: Nature Medicine. 18:429-435

In advanced cancer, including glioblastoma, the transforming growth factor β (TGF-β) pathway acts as an oncogenic factor and is considered to be a therapeutic target. Using a functional RNAi screen, we identified the deubiquitinating enzyme ubiquit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ddc32bc2480a9f0fd37fc8eca1cffd
https://doi.org/10.1038/nm.2619

Regulated HIV-2 RNA dimerization by means of alternative RNA conformations

Autor: Ben Berkhout, Hendrik Huthoff, Annette M.G. Dirac, Jørgen Kjems

Publikováno v: Nucleic Acids Research, 30(12), 2647-2655. Oxford University Press
Nucleic acids research, 30(12), 2647-2655. Oxford University Press
Scopus-Elsevier

The dimer initiation site (DIS) hairpin of the HIV-2 untranslated leader RNA mediates in vitro dimerization through 'loop-loop kissing' of a loop-exposed palindrome sequence. Premature RNA dimerization must be prevented during the retroviral life cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e23be97ba5efe0a234f1f57683f9af
https://doi.org/10.1093/nar/gkf381

Mapping DNA-binding sites of HIV-1 integrase by protein footprinting

Autor: Jørgen Kjems, Annette M.G. Dirac

Publikováno v: European Journal of Biochemistry. 268:743-751

The HIV-1 integrase protein catalyzes integration of the viral genome into host cell DNA. Whereas the structures of the three domains of integrase have been solved separately, both the structural organization of the full-length protein and its intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0669fc8c6d9315c28e5f68e1fc075b9f
https://doi.org/10.1046/j.1432-1327.2001.01932.x