Výsledky vyhledávání - "Annette M. Vogl"

Bis‐ethynylphosphonamidates as an Modular Conjugation Platform to Generate Multi‐Functional Protein‐ and Antibody‐Drug‐Conjugates

Autor: Marc‐André Kasper, Lukas Lassak, Annette M. Vogl, Isabelle Mai, Jonas Helma, Dominik Schumacher, Christian P. R. Hackenberger

Bis-ethynylphosphonamidates allow for a simple chemoselective addition of two thiol-containing modules in a row. We describe four such bis-electrophiles that carry different functional O-substituents with tunable hydrophilicity and enable further sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8910f1842006a28c72ee1d9597f101b
http://edoc.hu-berlin.de/18452/25489

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Akademický článek

MicroRNA-9 controls dendritic development by targeting REST

Autor: Sebastian A Giusti, Annette M Vogl, Marisa M Brockmann, Claudia A Vercelli, Martin L Rein, Dietrich Trümbach, Wolfgang Wurst, Demian Cazalla, Valentin Stein, Jan M Deussing, Damian Refojo

Publikováno v: eLife, Vol 3 (2014)

MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitor

Externí odkaz: https://doaj.org/article/8d59cdbcf0d342a4a0ce2238b26225f7

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Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety

Publikováno v: Nature reviews / Neuroscience 21(6), 803-807 (2018). doi:10.1038/s41593-018-0151-z
Nat. Neurosci. 21, 803-807 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cb6fb9c8125c204ce1bd4e894f0617

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Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition

Autor: Jan M. Deussing, Annette M. Vogl, Julia Richter, Marisa M Brockmann, Daniela M Vogt-Weisenhorn, Valentin Stein, Sebastian A. Giusti, Christoph W. Turck, Giuseppina Maccarrone, Corinna A Bauder, Claudia Alejandra Vercelli, Anne-Sophie Hafner, Francesco Roselli, Daniel Choquet, Nina Dedic, Damian Refojo, Carsten T. Wotjak

Publikováno v: Nature Neuroscience. 18:239-251

Neddylation is a ubiquitylation-like pathway that controls cell cycle and proliferation by covalently conjugating Nedd8 to specific targets. However, its role in neurons, nonreplicating postmitotic cells, remains unexplored. Here we report that Nedd8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94a07d732cd646192929aaea95f28cf
https://doi.org/10.1038/nn.3912

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Immunology, Signal Transduction, and Behavior in Hypothalamic-Pituitary-Adrenal Axis-related Genetic Mouse Models

Autor: Susana Silberstein, Annette M. Vogl, Florian Holsboer, Jan M. Deussing, Wolfgang Wurst, Damian Refojo, Juan José Bonfiglio, Eduardo Arzt

Publikováno v: Annals of the New York Academy of Sciences. 1153:120-130

A classical view of the neuroendocrine-immune network assumes bidirectional interactions where pro-inflammatory cytokines influence hypothalamic-pituitary-adrenal (HPA) axis-derived hormones that subsequently affect cytokines in a permanently servo-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54617ce79e54d725d98a71aae9e0b174
https://doi.org/10.1111/j.1749-6632.2008.03967.x

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Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior

Autor: Jan M. Deussing, Ailing Lu, Günter K. Stalla, Wolfgang Wurst, Annette M. Vogl, M. A. Steiner, Damian Refojo, S. M. Walser, John L.R. Rubenstein, Florian Holsboer, Nicolas Singewald, M Ableitner, Carsten T. Wotjak, Nigel Whittle, Marc Ekker

Publikováno v: Molecular Psychiatry. 13:1028-1042

Hypersecretion of central corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of affective disorders. Both, basic and clinical studies suggested that disrupting CRH signaling through CRH type 1 receptors (CRH-R1) can amel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e9ab53a123ea226a61928d43ce1ffa
https://doi.org/10.1038/mp.2008.51

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