Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Annette M. Silvia"'
Autor:
Jeffrey A. Pfefferkorn, Matthew Gorgoglione, Scott M. Turner, Clare Buckeridge, Nicholas B. Vera, Marc K. Hellerstein, Annette M. Silvia, Gabriele E. Sonnenberg, Santos Carvajal-Gonzalez, Kathleen Biddle, Paul A. Amor, Raja K Sivamani, Lauren A Hassoun, David A. Griffith, Carine Beysen, Steven M. Watkins, Timothy P. Rolph, Julie Purkal, Mark Fitch, Gregory J. Tesz, William P. Esler, Frank J. Geoly, Suzana S. Bosanac
Publikováno v:
Science translational medicine. 11(492)
Sebum plays important physiological roles in human skin. Excess sebum production contributes to the pathogenesis of acne vulgaris, and suppression of sebum production reduces acne incidence and severity. We demonstrate that sebum production in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed755d8f32090787a27b2b7eaeec5c2b
https://pubmed.ncbi.nlm.nih.gov/31092695
https://pubmed.ncbi.nlm.nih.gov/31092695
Autor:
Tong Zhu, Annette M. Silvia, Gabriella Bedarida, Mark J. Mitton-Fry, Wesley Jakubiec, Lynn Ladutko, Paul F. Miller, Robert S. Wallis, Vikas Kumar, Darcy Paige, Sheldon Campbell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:567-574
Tuberculosis is a serious global health threat for which new treatments are urgently needed. This study examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of the oxazolidinone PNU-100480 in healthy v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec8dc04ec5818d7ae460fb5167ba48d
https://doi.org/10.1128/aac.01179-10
https://doi.org/10.1128/aac.01179-10
Autor:
Chao Li, Rod Stevens, Jason K. Dutra, Annette M. Silvia, Michelle L. Haven, Scott B. Seibel, Erik L. Nimz, Ziegler Carl B, Kristin M. Lundy DeMello, Robert J. Rafka, Cheng Hengmiao, Martha L. Minich, Jin Li, Nicole L. Kolosko, Carol F. Petras, Subas M. Sakya, Donald W. Mann, Kazuo Ando, K. Kawamura, Carolyn Rose Kilroy, Lisa A. Lund, Burton H. Jaynes, Tomoki Kato
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2076-2080
The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure–activity relationship (SAR) studies of this class of compounds led to the identification of compound 1 which demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096af07029de50fcfe74128b57b3a069
https://doi.org/10.1016/j.bmcl.2006.01.059
https://doi.org/10.1016/j.bmcl.2006.01.059
Autor:
Suzanne H. St. Denis, Michelle L. Haven, Scott B. Seibel, Carol F. Petras, Subas M. Sakya, Lisa A. Lund, Annette M. Silvia, Michael P. Lynch, Bryson Rast, Cheng Hengmiao, Martha L. Minich, Burton H. Jaynes, Kristin M. Lundy DeMello, Donald W. Mann, Andrei Shavnya, Anne Hickman, Ziegler Carl B, David A. Koss, David M. George, Robert J. Rafka, Jin Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:288-292
Structure-activity relationship (SAR) studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-yl]-5-methanesulfonyl (SO(2)Me)/sulfamoyl (SO(2)NH(2))-pyridine derivatives for canine COX enzymes are described. The studies led to the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287d246c2a3746f106e9752c3bac59e
https://doi.org/10.1016/j.bmcl.2005.10.006
https://doi.org/10.1016/j.bmcl.2005.10.006
Autor:
Rhonda M. Crosson, David A. Koss, Michelle L. Haven, Carolyn Rose Kilroy, Martha L. Minich, Robert J. Rafka, Eric L. Nimz, Morton Barry James, Scott B. Seibel, Lisa A. Lund, Carol F. Petras, Kristin M. Lundy DeMello, Chao Li, Annette M. Silvia, Bryson Rast, Kathleen M. Callaghan, Andrei Shavnya, Michael P. Lynch, Subas M. Sakya, Ziegler Carl B, Jin Li, Nicole L. Kolosko, Bronk Brian Scott, Donald W. Mann, Jason K. Dutra, Burton H. Jaynes, Henry Cheng, Glen W. Kirk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:95-98
Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f71036c4dab955ec24afc57075467a
https://doi.org/10.1016/j.bmcl.2003.10.004
https://doi.org/10.1016/j.bmcl.2003.10.004
Autor:
Amour Venter, Tong Zhu, Kathleen D. Eisenach, Sven O. Friedrich, Yao Zhang, Jason Gobey, Annette M. Silvia, Andreas H. Diacon, Paul F. Miller, Craig A. Ellery, Rodney Dawson, Robert S. Wallis, Darcy Paige
Publikováno v:
PLoS One
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94462 (2014)
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94462 (2014)
Rationale Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations conferring resistance to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dd3d9d49a3cd6d6f5bae47e0fad0bf
Publikováno v:
The Journal of Antibiotics. 52:52-60
A systematic analysis of the bacteriostatic/bactericidal effect of several antibiotics used in veterinary medicine was carried out by time-kill kinetic analysis using P. haemolytica, P. multocida, A. pleuropneumoniae, and E. coli. The antibiotics tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a464a24d3adcdc8cddeb4911e8360d1
https://doi.org/10.7164/antibiotics.52.52
https://doi.org/10.7164/antibiotics.52.52
Autor:
Jefson Martin R, Suzanne L. Haskell, N. C. Elliott, L. J. Lafleur, E. P. Cisek, F. H. Weber, M. J. Rosenfeld, M. S. Hindahl, C. P. Cornell, D. D. Mann, P. Chang, Annette M. Silvia, Mcguirk Paul R, Thomas D. Gootz, T. R. Shryock
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e807ae69d2b626c573641f8d832cb9b5
https://doi.org/10.1002/chin.199226199
https://doi.org/10.1002/chin.199226199
Autor:
Paul F. Miller, Robert S. Wallis, Darcy Paige, Annette M. Silvia, Dessislava Dimitrova, Vikas Kumar, Lynn Ladutko, Xiaoxi Li, Mark J. Mitton-Fry, Wesley Jakubiec, Sheldon Campbell, Gerald Friedland
Publikováno v:
The Journal of infectious diseases. 202(5)
BACKGROUND The oxazolidinone PNU-100480 is superior to linezolid against experimental murine tuberculosis. Two metabolites contribute to but do not fully account for its superiority. This study examined the safety, tolerability, pharmacokinetics, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4961a486c8b04edaa00f7707a6eada45
https://pubmed.ncbi.nlm.nih.gov/20629533
https://pubmed.ncbi.nlm.nih.gov/20629533
Autor:
Jay M. Bergeron, James A. Retsema, Laura J. L. Norcia, Shigeru F. Hayashi, John P. Dirlam, Rodney Caughren Schnur, Annette M. Silvia
Publikováno v:
ChemInform. 31
Two cyclic homopentapeptides, CP-101,680 and CP-163,234 [6a-(3',4'-dichlorophenylamino) analogs of viomycin and capreomycin, respectively], were identified as novel antibacterial agents for the treatment of animal disease, especially for livestock re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a7a917d07c81ea911874502b77e40e
https://doi.org/10.1002/chin.200014174
https://doi.org/10.1002/chin.200014174