Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Annette M. Shewan"'
Autor:
Lucía F. Zacchi, John C. Dittmar, Michael J. Mihalevic, Annette M. Shewan, Benjamin L. Schulz, Jeffrey L. Brodsky, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1129-1140 (2017)
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of dystonia is early-onset torsion dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Externí odkaz:
https://doaj.org/article/f7ac7a235cf04b5ba2e8af83825ca350
Publikováno v:
eLife, Vol 2 (2013)
Apical secretion from epithelial tubes of the Drosophila embryo is mediated by apical F-actin cables generated by the formin-family protein Diaphanous (Dia). Apical localization and activity of Dia are at the core of restricting F-actin formation to
Externí odkaz:
https://doaj.org/article/c66273c97d0a4fdbab3fdc17b75b88e6
Autor:
Ana L. Diez Tissera, Annette M. Shewan, Jonas Honer, Lucia F. Zacchi, Julio J. Caramelo, Benjamin L. Schulz, Chun Zhou, Jeffrey L. Brodsky, Christian Fercher, Noushin Jaberolansar, Katie M. Niemeyer, Yohaann M. A. Jafrani
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(9)
The Endoplasmic Reticulum (ER) is responsible for the folding and post-translational modification of secretory proteins, as well as for triaging misfolded proteins. During folding, there is a complex yet only partially understood interplay between di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070539292f40a6c6beb6986857c1c250
https://pubmed.ncbi.nlm.nih.gov/34062155
https://pubmed.ncbi.nlm.nih.gov/34062155
Autor:
Michael J. G. Milevskiy, Brooke L. Brewster, Darren Korbie, Annette M. Shewan, Gurveen K Sandhu, Stacey L. Edwards, Anna Wronski, Juliet D. French, Melissa A. Brown
Publikováno v:
Oncotarget
Depletion of BRCA1 protein in mouse mammary glands results in defects in lactational development and increased susceptibility to mammary cancer. Extensive work has focussed on the role of BRCA1 in the normal breast and in the development of breast ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6267a61343241a0857b04b951331d33b
http://europepmc.org/articles/PMC6173367
http://europepmc.org/articles/PMC6173367
Publikováno v:
Journal of Biological Chemistry. 291:20345-20352
The identification of ANO1/TMEM16A as the likely calcium-dependent chloride channel of exocrine glands has led to a more detailed understanding of its biophysical properties. This includes a calcium-dependent change in channel selectivity and evidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38ba0154ad64069e461b13c30fafe71
https://doi.org/10.1074/jbc.m116.750224
https://doi.org/10.1074/jbc.m116.750224
Autor:
John C. Dittmar, Jeffrey L. Brodsky, Annette M. Shewan, Michael J. Mihalevic, Lucia F. Zacchi, Benjamin L. Schulz, Kara A. Bernstein
Publikováno v:
Disease Models & Mechanisms.
Dystonia is the third most common movement disorder, but its diagnosis and treatment remain challenging. One of the most severe types of Dystonia is Early-Onset Torsion Dystonia (EOTD). The best studied and validated EOTD-associated mutation, torsinA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fd1c42245e3c3097b679a485ded4fa
https://doi.org/10.1242/dmm.029926
https://doi.org/10.1242/dmm.029926
Autor:
Melissa A. Brown, Juliet D. French, Amy E. McCart Reed, Annette M. Shewan, Dennis H. Dowhan, Joshua A. Betts, Julia Margaret Wendy Gee, Stacey L. Edwards, Eloise Dray, Susan J. Clark, Fares Al-Ejeh, Peter Bailey, Michael J. G. Milevskiy, Korinne Northwood, Jodi M. Saunus, Kenneth P. Nephew, Sunil R. Lakhani, Andrew Stone
Publikováno v:
Human Molecular Genetics
Predicting response to endocrine therapy and survival in oestrogen receptor positive breast cancer is a significant clinical challenge and novel prognostic biomarkers are needed. Long-range regulators of gene expression are emerging as promising biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e343d1745c19aafe538f66daae24b65
Autor:
Annette M. Shewan, Rachel Templin, Richard I. Webb, Wei Ma, Herbert Y. Gaisano, Michael Zavortink, Robyn Webb, Peter Thorn, Christine Ludick, Philip Poronnik, Wan Jun Gan, Robert G. Parton
Publikováno v:
Journal of Cell Science
The structural organisation of pancreatic β-cells in the islets of Langerhans is relatively unknown. Here, using three-dimensional (3D) two-photon, 3D confocal and 3D block-face serial electron microscopy, we demonstrate a consistent in situ polaris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8422568f708490d209de4e325ed4a6a
https://doi.org/10.1242/jcs.185116
https://doi.org/10.1242/jcs.185116
Autor:
Mirjam M. P. Zegers, Qi-Wen Fan, David M. Bryant, William A. Weiss, Dennis J. Eastburn, Annette M. Shewan, Keith E. Mostov, Wei Yu, Paul Brakeman, Anirban Datta
Publikováno v:
EMBO reports. 9:923-929
In multicellular epithelial tissues, the orientation of polarity of each cell must be coordinated. Previously, we reported that for Madin-Darby canine kidney cells in three-dimensional collagen gel culture, blockade of beta1-integrin by the AIIB2 ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47929418f75a25d85dc4ea561714cff4
https://doi.org/10.1038/embor.2008.135
https://doi.org/10.1038/embor.2008.135
Publikováno v:
The Journal of Cell Biology
Cooperation between cadherins and the actin cytoskeleton controls many aspects of epithelial biogenesis. We report here that myosin VI critically regulates the morphogenesis of epithelial cell–cell contacts. As epithelial monolayers mature in cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e04a23823bf7112b8167dd9739f49
http://europepmc.org/articles/PMC2064848
http://europepmc.org/articles/PMC2064848