Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Annette M. Gero"'
Publikováno v:
Chemico-Biological Interactions. 240:102-109
Fluorinated nucleoside analogues are a major class of cancer chemotherapy agents, and include the drugs 5-fluorouracil (5FU) and 5-fluoro-2'-deoxyuridine (FdUrd). The aim of this study was to examine the cellular toxicity of two novel fluorinated pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018d220f39597240c1e3c243ef04a267
https://doi.org/10.1016/j.cbi.2015.08.010
https://doi.org/10.1016/j.cbi.2015.08.010
Trichomonas vaginalis: Detection of Nucleoside Hydrolase Activity as a Potential Screening Procedure
Autor:
Keith Clinch, Edward W. Kang, Jo E. Harvey, Richard H. Furneaux, Annette M. Gero, Philip J. Schofield
Publikováno v:
Experimental Parasitology. 94:125-128
Gero, A. M., Kang, E. W., Harvey, J. E., Schofield, P. J., Clinch, K., and Furneaux, R. H. 2000. Trichomonas vaginalis: Detection of nucleoside hydrolase activity as a potential screening procedure. Experimental Parasitology94, 125–128.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2ef7ded897ef29854cf3d1272e213f
https://doi.org/10.1006/expr.1999.4484
https://doi.org/10.1006/expr.1999.4484
Publikováno v:
Nucleosides and Nucleotides. 18:885-889
L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df995a950ccba10ad9a6ff9a7d9b1a5
https://doi.org/10.1080/15257779908041593
https://doi.org/10.1080/15257779908041593
Publikováno v:
Experimental Parasitology. 90:181-188
Hall, S. T., Penny, J. I., Gero, A. M., and Krishna, S. 1998.Crithidia luciliae: Functional expression of nucleoside and nucleobase transporters inXenopus laevisoocytes.Experimental Parasitology90, 181–188. The expression of purine-specific nucleos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539d731a6f09e191c7fc2720fc6f18a0
https://doi.org/10.1006/expr.1998.4320
https://doi.org/10.1006/expr.1998.4320
Autor:
Simone T. Hall, Charles J. Woodrow, Jeffrey Penny, Gill M. Cowan, Annette M. Gero, Sanjeev Krishna
Publikováno v:
Molecular and Biochemical Parasitology. 93:81-89
When the malarial parasite Plasmodium falciparum multiplies in erythrocytes it dramatically increases uptake of essential metabolic precursors (nucleosides, nucleobases and glucose) and export of lactic acid by undefined mechanisms. The first evidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7477c3cd275563ca97b27dc467554c28
https://doi.org/10.1016/s0166-6851(98)00024-3
https://doi.org/10.1016/s0166-6851(98)00024-3
Publikováno v:
International Journal for Parasitology. 27:241-249
Nutritional insufficiency is a common environmental extreme to which parasitic protozoa are routinely exposed. In this study of purine salvage mechanisms we illustrate some successful adaptations of the parasite Crithidia luciliae to its environment,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec80383fac9dab29b51cc8338c876e6
https://doi.org/10.1016/s0020-7519(96)00153-1
https://doi.org/10.1016/s0020-7519(96)00153-1
Publikováno v:
Experimental Parasitology. 83:314-321
During the growth cycle of the protozoan parasite Crithidia luciliae, there was a dramatic concomitant increase in the rate of adenosine and guanosine transport and 3' nucleotidase (3'NTase) activity after 72-94 hr. The simultaneous increased activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93e2672551854897c2e76ee18a78f8a
https://doi.org/10.1006/expr.1996.0079
https://doi.org/10.1006/expr.1996.0079
Autor:
Joanne M. Upston, Annette M. Gero
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1236:249-258
A mechanism which mediates the transport of the nonphysiological nucleoside, l -adenosine, was demonstrated in Plasmodium falciparum infected erythrocytes and naturally released merozoites. l -Adenosine was not a substrate for influx in freed intraer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d337d6f651129d6b57278e78e99006df
https://doi.org/10.1016/0005-2736(95)00055-8
https://doi.org/10.1016/0005-2736(95)00055-8
Publikováno v:
Experimental parasitology. 132(4)
The anti-malarial activity of the cancer chemotherapeutic agent cisplatin and cisplatin analogues was determined in Plasmodium falciparum. The cisplatin analogues included DNA-targeted acridine-tethered platinum compounds, carboplatin and transplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8090a4242fb301fd0b7901a02d9efd
https://pubmed.ncbi.nlm.nih.gov/23000555
https://pubmed.ncbi.nlm.nih.gov/23000555
Publikováno v:
Journal of Applied Bacteriology. 77:1-8
The incorporation of pyrimidine nucleotide precursors into Helicobacter pylori and the activities of enzymes involved in their synthetic pathways were investigated by radioactive tracer analysis and 31P nuclear magnetic resonance spectroscopy. The ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ae40b3959ac6593763acdf97fea2f5
https://doi.org/10.1111/j.1365-2672.1994.tb03036.x
https://doi.org/10.1111/j.1365-2672.1994.tb03036.x