Peptide-based subunit vaccine against hookworm infection.

Autor: Mariusz Skwarczynski, Annette M Dougall, Makan Khoshnejad, Saranya Chandrudu, Mark S Pearson, Alex Loukas, Istvan Toth

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46870 (2012)

Hookworms infect more people than HIV and malaria combined, predominantly in third world countries. Treatment of infection with chemotherapy can have limited efficacy and re-infections after treatment are common. Heavy infection often leads to debili

Externí odkaz: https://doaj.org/article/50b0f838c98d4717b96f6277fc364837

Type I interferon is required for T helper (Th) 2 induction by dendritic cells

Autor: Jessica G. Borger, Benjamin G Dewals, Daniel M. Davis, Sheila Brown, Alexander T. Phythian-Adams, Annette M. Dougall, Adam N.R. Cartwright, Cecilia Johansson, Ruud H. P. Wilbers, Rachel J. Lundie, Peter C. Cook, Lucy H. Jackson-Jones, Franca Ronchese, Andrew S. MacDonald, Lauren M. Webb, Lisa M. Connor

Publikováno v: The EMBO Journal 36 (2017) 16
Webb, L M, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A N R, Dougall, A M, Wilbers, R, Cook, P, Jackson-Jones, L, Phythian-Adams, A T, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', EMBO Journal . https://doi.org/10.15252/embj.201695345
The EMBO Journal, 36(16), 2404-2418
The EMBO Journal
Webb, L, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A, Dougall, A M, Wilbers, R H P, Cook, P, Jackson-Jones, L H, Phythian-Adams, A, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', The EMBO Journal, vol. 36, no. 16, pp. 2404-2418 . https://doi.org/10.15252/embj.201695345

Type 2 inflammation is a defining feature of infection with parasitic worms(helminths), as well as being responsible for widespread suffering in allergies.However, the precise mechanisms involved in T helper (Th) 2 polarization bydendritic cells (DCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5f92340a77d94b2ece85380484c954
https://doi.org/10.15252/embj.201695345

Recruitment of hepatic macrophages from monocytes is independent of IL-4Rα but is associated with ablation of resident macrophages in schistosomiasis

Autor: François Lallemand, Marion Rolot, Annette M. Dougall, Justine Javaux, Benjamin G Dewals, Bénédicte Machiels, Laurent Gillet, Philippe Martinive

Publikováno v: European Journal of Immunology

Alternatively activated Mφs (AAMφ) accumulate in hepatic granulomas during schistosomiasis and have been suggested to originate in the bone marrow. What is less understood is how these Mφ responses are regulated after S. mansoni infection. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0eeb56515f0b2ce4af4fe152ca4f5
https://pubmed.ncbi.nlm.nih.gov/31267552

Genome of the human hookworm Necator americanus

Autor: Veena Bhonagiri-Palsikar, Paul W. Sternberg, Shoba Ranganathan, Javier Sotillo, Robin B. Gasser, Jason Mulvenna, John Martin, Bruce A. Rosa, Soraya Gaze, Yat T. Tang, Xu Zhang, Wesley C. Warren, Makedonka Mitreva, Richard K. Wilson, Bin Zhan, Patrick Minx, Xin Gao, Esley M. Heizer, Alex Loukas, Sahar Abubucker, Peter J. Hotez, Jeffrey M. Bethony, Philip L. Felgner, John M. Hawdon, Élida Mara Leite Rabelo, Qi Wang, Kymberlie Hallsworth-Pepin, Annette M. Dougall, Rahul Tyagi

Publikováno v: Nature genetics

The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258806afc6abe4a8d442330df2378223
https://doi.org/10.1038/ng.2875

IDENTIFICATION AND CHARACTERIZATION OF SARCOPTES SCABIEI AND DERMATOPHAGOIDES PTERONYSSINUS GLUTATHIONE S-TRANSFERASES: IMPLICATION AS A POTENTIAL MAJOR ALLERGEN IN CRUSTED SCABIES

Autor: Shelley F. Walton, David J. Kemp, Annette M. Dougall, Bart J. Currie, Katja Fischer, Deborah C. Holt

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 73:977-984

The astigmatid mite Sarcoptes scabiei is the causative agent of scabies, a highly infectious parasitic disease of the skin. Although the mite causes marked hypersensitivity reactions, particularly in crusted (severe) scabies, little is known about th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4910adb230b592c3eb17e481f6fa7df0
https://doi.org/10.4269/ajtmh.2005.73.977