Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Annette Lucman"'
Autor:
Kristen Sebring, Dominic P. Behan, James N. Leonard, Chris Carroll, Annette Lucman, Jinyao Zhou, Charles Xing, Robert M. Jones, David J. Unett, Jean Alfonso, Veronica Gutierrez, Hongmei He, Ruoping Chen, Brandee Wagner, Zhi-Liang Chu
Publikováno v:
Molecular Endocrinology. 24:161-170
G protein-coupled receptor 119 (GPR119) is largely restricted to pancreatic insulin-producing beta-cells and intestinal glucagon-like peptide-1-producing L-cells. Synthetic agonists of this receptor elicit glucose-dependent release of these endocrine
Autor:
Didier Bagnol, Dominic P. Behan, Hui Gao, James N. Leonard, Zhi-Liang Chu, Melinda Pedraza, Hongmei He, Jean Alfonso, Veronica Gutierrez, Ruoping Chen, Helen Mondala, Annette Lucman, Robert M. Jones, Chris Carroll
Publikováno v:
Endocrinology. 149(5)
We recently showed that activation of G protein-coupled receptor 119 (GPR119) (also termed glucose dependent insulinotropic receptor) improves glucose homeostasis via direct cAMP-mediated enhancement of glucose-dependent insulin release in pancreatic
Autor:
Graeme Semple, Dominic P. Behan, James N. Leonard, David J. Unett, Annette Lucman, Molly Moloney, Helen Mondala, Hongmei He, Chris Carroll, Veronica Gutierrez, Zhi-Liang Chu, Yin Liang, Robert M. Jones, Keith T. Demarest, Hui Gao, Didier Bagnol
Publikováno v:
Endocrinology. 148(6)
Pancreatic beta-cell dysfunction is a hallmark event in the pathogenesis of type 2 diabetes. Injectable peptide agonists of the glucagon-like peptide 1 (GLP-1) receptor have shown significant promise as antidiabetic agents by virtue of their ability