Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Annette Koerner"'
Publikováno v:
CHIMIA, Vol 72, Iss 7-8 (2018)
Glycine transporter-1 (GlyT1) inhibition has been extensively studied both in pharmaceutical companies and academic institutions primarily as a potential new approach to treat schizophrenia, a severe and chronic mental illness. More recently, preclin
Externí odkaz:
https://doaj.org/article/8c0a3d50696a46f38ab15715e29fc2a6
Autor:
Juergen Dukart, Omar Khwaja, Carlo Brugnara, Dietmar Volz, Stephane Nave, Annette Koerner, Ricardo Hermosilla, Dominik Kraus, Erica Winter, Vip Viprakasit, Patrick Cech, Ali T. Taher, Maria Domenica Cappellini
Publikováno v:
British journal of haematology 194(2), 474–481 (2021). doi:10.1111/bjh.17479
Bitopertin is a small molecule selective inhibitor of glycine transporter 1 (GlyT1), initially developed to increase brain extracellular levels of glycine in the vicinity of neuronal N-methyl-D-aspartate receptors for the treatment of schizophrenia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53b29f7c139f162902d17a743fee507
https://juser.fz-juelich.de/record/893884
https://juser.fz-juelich.de/record/893884
Autor:
Tomas Tomka, Achille Iolascon, Lucia De Franceschi, Christhophe Lebouef, Maria Luisa Di Paolo, Franco Turrini, Annette Koerner, Immacolata Andolfo, Luigia De Falco, Norman A. Mazer, Enrica Federti, Jane-Jane Chen, Alessandro Matte, Anja Harmeier, Alejandra Macias-Garcia, Anne Janin, Carlo Brugnara, Michael Winter, Elisabetta Beneduce
Anemia of β-thalassemia is caused by ineffective erythropoiesis and reduced red cell survival. Several lines of evidence indicate that iron/heme restriction is a potential therapeutic strategy for the disease. Glycine is a key initial substrate for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ce3c31286a9dce2137183ed81f9079
http://hdl.handle.net/11588/768904
http://hdl.handle.net/11588/768904
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:144-150
Introduction We describe experience with an unexpectedly high background incidence of atrioventricular block (AVB) observed in Mauritian cynomolgus monkeys (MCM) during preclinical safety assessment for bitopertin, a glycine-transporter-1 inhibitor.
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 107:148-156
Bitopertin is a glycine type 1 (GlyT1) inhibitor intended for the treatment of psychiatric disorders. The principle adverse effect in the regulatory reproductive toxicity studies was peri-natal pup death when rat dams were treated during parturition
Publikováno v:
CHIMIA, Vol 72, Iss 7-8 (2018)
Glycine transporter-1 (GlyT1) inhibition has been extensively studied both in pharmaceutical companies and academic institutions primarily as a potential new approach to treat schizophrenia, a severe and chronic mental illness. More recently, preclin
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 107(3)
Bitopertin is a glycine type 1 (GlyT1) inhibitor intended for the treatment of psychiatric disorders. The principle adverse effect in the regulatory reproductive toxicity studies was peri-natal pup death when rat dams were treated during parturition
Autor:
Omar Khwaja, Elisabetta Beneduce, Michael Winter, Angela Siciliano, Lucia De Franceschi, Carlo Brugnara, Thomas Singer, Alessandro Matte, Anja Harmeier, Annette Koerner, Enrica Federti
The unbalanced hemoglobin chain synthesis in beta-thalassemias leads to hemichrome-induced damage that contributes to ineffective erythropoiesis, hemolysis and reduced red cell survival. Iron overload related to ineffective erythropoiesis and abnorma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e6f332ccf7d56de1c9e0bb14c69904
http://hdl.handle.net/11562/958494
http://hdl.handle.net/11562/958494
Autor:
Tom Chu, Markus Britschgi, Eric Prinssen, Regina Dutkowski, Annette Koerner, Bharat Thakrar, Sudhir Bansod, Craig R Rayner, Stephen Toovey, Alexandra Sirzen-Zelenskaya, Barbara Donner
Publikováno v:
Advances in Therapy. 29:826-848
A 2008 review by our group concluded that the risk of neuropsychiatric adverse events (NPAEs) in influenza patients was not increased by oseltamivir exposure, and did not identify any mechanism by which oseltamivir or its metabolites could cause or w
Autor:
Elizabeth Theogaraj, Thierry Lavé, Brian E. Davies, Thomas Singer, Gerhard Hoffmann, Neil Parrott, Annette Koerner, Eric Prinssen
Publikováno v:
Clinical Pharmacokinetics. 50:613-623
Background: Physiologically based pharmacokinetic (PBPK) modelling can assist in the development of drug therapies and regimens suitable for challenging patient populations such as very young children. This study describes a strategy employing PBPK m