Výsledky vyhledávání - "Annette J. Self"

Supplementary Data Figure S1-S8 from A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer

Autor: Steven R. Whittaker, David E. Root, Federica Piccioni, Udai Banerji, Paul A. Clarke, Annette J. Self, Charlotte K. Milton

Figure S1. KRAS-dependency and effect of Cas9 expression on response to PI3K inhibition. Figure S2. Whole-genome CRISPR screen shows good replicate correlation and identifies enhancers and suppressors of GDC0941 antiproliferative activity. Figure S3.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8942982ad09090c20725f0378db61c40
https://doi.org/10.1158/1535-7163.22521184

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Alan Hall (1952-2015), an Englishman in New York

Autor: Annette J. Self, Sandrine Etienne-Manneville

Publikováno v: EMBO Journal
EMBO Journal, 2015, 34 (13), pp.1735-1736. ⟨10.15252/embj.201570020⟩
EMBO Journal, EMBO Press, 2015, 34 (13), pp.1735-1736. ⟨10.15252/embj.201570020⟩

Alan closing his departing speech at LMCB in 2006 by featuring his lab. Image by Ione Karney. ![][1] Alan Hall died of a heart attack during his regular Sunday morning jog on May 3rd in New York City, where he had lived with his wife Eileen. Alan's u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406cc5d9af9c52f5c337800c1849a7de
https://hal-pasteur.archives-ouvertes.fr/pasteur-02059086

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Analysis of R-Ras signalling pathways

Autor: Alan Hall, Annette J. Self, Emmanuelle Caron, H.F. Paterson

Publikováno v: Journal of Cell Science. 114:1357-1366

R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and M-Ras. Activated versions of Ras and TC21 are highly transforming in a variety of cell lines and mutated forms of both proteins have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc4513f2065480e641755fb54483623
https://doi.org/10.1242/jcs.114.7.1357

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The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 by LPS and other inflammatory mediators

Autor: Emmanuelle Caron, Annette J. Self, Alan Hall

Publikováno v: Current Biology. 10(16):974-978

BACKGROUND: beta2 integrins mediate many aspects of the inflammatory and immune responses, including adhesion of leukocytes to the endothelium, complement-mediated phagocytosis in macrophages and neutrophils, and antigen-specific conjugate formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fa28cd03b26aed8da1ebad50a55794

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Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

Autor: Myrto Raftopoulou, Alan Hall, Annette J. Self, Sandrine Etienne-Manneville, Sarah Nicholls

Publikováno v: Science. 303:1179-1181

PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, indep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ecd9a13dd08356611ba6fccff5708e
https://doi.org/10.1126/science.1092089

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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho

Autor: Catherine D. Nobes, Mariëtte H.E. Driessens, Alan Hall, Ingrid Jordens, Corey S. Goodman, Hailan Hu, Annette J. Self

Publikováno v: Current biology : CB. 11(5)

Semaphorins and their receptors, plexins, are widely expressed in embryonic and adult tissues. In general, their functions are poorly characterized, but in neurons they provide essential attractive and repulsive cues that are necessary for axon guida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f02140d024173dc7abfe3fe3eb744b8
https://pubmed.ncbi.nlm.nih.gov/11267870

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[1] Purification of recombinant Rho/Rac/G25K from Escherichia coli

Autor: Annette J. Self, Alan Hall

Publisher Summary This chapter discusses the purification method of recombinant Rho/Rac/G25K from Escherichia coli . The purification of Ras-related GTP-binding proteins from recombinant sources has proved to be invaluable for studying their biochemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f3e01b7b8d8d16a73b5e37ac0801137
https://doi.org/10.1016/0076-6879(95)56003-3

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[8] Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates

Autor: Alan Hall, Annette J. Self

Publisher Summary This chapter describes methods to measure nucleotide exchange rates and GTP hydrolysis rates of Rho, Rac, and G25K. Like all GTP-binding proteins, Rho-related GTPases exist in two conformational states: an inactive GDP-bound form an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d69674d5ec47b447f29982653bd8fa55
https://doi.org/10.1016/0076-6879(95)56010-6

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rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo

Autor: Anita C. Hall, C. Ellis, Hugh Paterson, Anne J. Ridley, Christopher J. Marshall, F. Kasmi, Annette J. Self

Publikováno v: Europe PubMed Central

rho family GTPases link extracellular signals to changes in the organization of cytoskeletal actin. Serum stimulation of quiescent Swiss 3T3 fibroblasts leads to rho-dependent actin stress fibre formation and focal adhesions, whilst several growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074d26eb0193aa8ba0888cce74859a12
http://europepmc.org/abstract/med/8262058

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