Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Annette J. Eckardt"'
Autor:
Raymond J. Patch, Rui Zhang, Suzanne Edavettal, Mark J. Macielag, Annette J. Eckardt, Jiali Li, Marie-Laure Rives, Wilson Edwards, Simon A. Hinke, Xi Qiu, Wenying Jian, Ondrej Libiger, Songmao Zheng, Jey Jeyaseelan, Yin Liang, Shamina M. Rangwala, James N. Leonard, Pamela Hornby
Publikováno v:
European Journal of Medicinal Chemistry. 236:114330
Pramlintide is an equipotent amylin analogue that reduces food intake and body weight in obese subjects and has been clinically approved as an adjunctive therapy for the treatment of adult diabetic patients. However, due to its extremely short half-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7177bbd3d99daefb5c3f38725b747b7e
https://doi.org/10.1016/j.ejmech.2022.114330
https://doi.org/10.1016/j.ejmech.2022.114330
Autor:
Annette J. Eckardt, Enrico Di Cera, Jack A. Kauffman, Edward C. Giardino, Thomas W. Corcoran, Michael N. Greco, Bruce E. Maryanoff, Lawrence de Garavilla, Claudia K. Derian, Narayanasami Sukumar, Barbara J. Haertlein, Zhi-wei Chen, Bruce P. Damiano, Grace I. Wells, Patricia Andrade-Gordon, F. Scott Mathews, Agustin O. Pineda
Publikováno v:
Journal of Biological Chemistry. 280:18001-18007
Certain leukocytes release serine proteases that sustain inflammatory processes and cause disease conditions, such as asthma and chronic obstructive pulmonary disease. We identified beta-ketophosphonate 1 (JNJ-10311795; RWJ-355871) as a novel, potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb41a9acbf419e02cb964ca95c9e201
https://doi.org/10.1074/jbc.m501302200
https://doi.org/10.1074/jbc.m501302200
Autor:
Hong Ye, Annette J. Eckardt, Charles E. Smith, Han-Cheng Zhang, David F. McComsey, Bruce E. Maryanoff, Wai-man Cheung, Bruce P. Damiano, Claudia K. Derian, Keith T. Demarest, Stuart Emanuel, Patricia Andrade-Gordon, Kimberly White, Diane R. Croll, Bruce R. Conway, Leonard R. Hecker, Michael F. Addo, Jian Li, Quan Li
Publikováno v:
Journal of Medicinal Chemistry. 48:1725-1728
Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. We identified low-nanomolar inhibitors of PKC-beta with good to excellent selectivity vs other PKC isozymes and GSK-3beta. In a cell-based functional assay, 8f and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58229b9216bbae205d9250ebc6834928
https://doi.org/10.1021/jm049478u
https://doi.org/10.1021/jm049478u
Autor:
Annette J. Eckardt, Claudia K. Derian
Publikováno v:
Experimental Cell Research. 232:1-7
Cellular responses to alpha-thrombin are mediated through a G-protein-coupled receptor that undergoes proteolytic cleavage, unveiling a tethered peptide ligand with the amino-terminal sequence SFLLRN. The synthetic peptide SFLLRN can mimic many of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7aa15b73d45722e87b4c93fdf30af7
https://doi.org/10.1006/excr.1997.3483
https://doi.org/10.1006/excr.1997.3483
Autor:
Annette J. Eckardt, Mary Pat Beavers, Kevin H. Mayo, Patricia Keane, Hoekstra William J, Francis Fan, Patricia Andrade-Gordon
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1296:95-102
The tripeptide RGD is well known for its role in integrin receptor-mediated cell-cell surface adhesion. Here, NMR and transferred NOE studies have been done with the fibrinogen/fibronectin-derived hexapeptide GRGDSP in the presence of sodium dodecyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14c1e591f29cb04fb5bc2bb23d3a509
https://doi.org/10.1016/0167-4838(96)00057-x
https://doi.org/10.1016/0167-4838(96)00057-x
Autor:
Hoekstra William J, Kevin H. Mayo, Mary Pat Beavers, Patricia Andrade-Gordon, Francis Fan, Patricia Keane, Annette J. Eckardt
Publikováno v:
FEBS Letters. 378:79-82
Fibrinogen gamma-chain C-terminal peptide HHLG-GAKQAGDV (gamma 12) and alpha-chain peptide GRGDSP are known to inhibit fibrinogen-mediated platelet cell aggregation via competitive interactions with platelet integrin receptor GPIIb/IIIa. NMR studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b197d3f3f20e66a8ec264976df027a73
https://doi.org/10.1016/0014-5793(95)01418-7
https://doi.org/10.1016/0014-5793(95)01418-7
Autor:
Andrew L. Darrow, Stanley M. Belkowski, Annette J. Eckardt, Cailin Chen, Michael R. D'Andrea, Hong Xin, Daniel Horowitz, Carlos R. Plata-Salaman, Derrick Maley, Sergey E. Ilyin, Claudia K. Derian
Publikováno v:
Methods (San Diego, Calif.). 37(3)
Microarray technology enables high-throughput testing of gene expression to investigate various neuroscience related questions. This in turn creates a demand for scalable methods to confirm microarray results and the opportunity to use this informati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dd95cf7457a7970e37d621de3cf448
https://pubmed.ncbi.nlm.nih.gov/16308157
https://pubmed.ncbi.nlm.nih.gov/16308157
Autor:
Lawrence, de Garavilla, Michael N, Greco, Narayanasami, Sukumar, Zhi-Wei, Chen, Agustin O, Pineda, F Scott, Mathews, Enrico, Di Cera, Edward C, Giardino, Grace I, Wells, Barbara J, Haertlein, Jack A, Kauffman, Thomas W, Corcoran, Claudia K, Derian, Annette J, Eckardt, Bruce P, Damiano, Patricia, Andrade-Gordon, Bruce E, Maryanoff
Publikováno v:
The Journal of biological chemistry. 280(18)
Certain leukocytes release serine proteases that sustain inflammatory processes and cause disease conditions, such as asthma and chronic obstructive pulmonary disease. We identified beta-ketophosphonate 1 (JNJ-10311795; RWJ-355871) as a novel, potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e05923a4bb3d7e129372ad39bb2c265
https://pubmed.ncbi.nlm.nih.gov/15741158
https://pubmed.ncbi.nlm.nih.gov/15741158
Autor:
Han-Cheng Zhang, David F. McComsey, Richard Look, Patricia Andrade-Gordon, Annette J. Eckardt, Lori Westover, Keith T. Demarest, Bruce R. Conway, Bruce E. Maryanoff, Stuart Emanuel, Jun Z. Xu, Kimberly White, Michael F. Addo, Hong Ye, Claudia K. Derian
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
Efficient methods were developed to synthesize a novel series of macrocyclic bisindolylmaleimides containing linkers with multiple heteroatoms. Potent inhibitors (single digit nanomolar IC(50)) for PKC-beta and GSK-3beta were identified, and compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6952fa6cabc771311c8f8efc0d23cf4d
https://pubmed.ncbi.nlm.nih.gov/12941331
https://pubmed.ncbi.nlm.nih.gov/12941331
Autor:
Rosemary J. Santulli, Kimberly White, Elwood E. Reynolds, Robert M. Scarborough, Patricia Andrade-Gordon, Annette J. Eckardt, Andrew L. Darrow, Michael F. Addo, Bruce E. Maryanoff, Donna Oksenberg, Claudia K. Derian, Hoekstra William J, Charles E. Smith, Han-Cheng Zhang, David F. McComsey
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 96(22)
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G protein-coupled receptors, which are enzymatically cleaved to expose a truncated extracellular N terminus that acts as a tethered activating ligand. PAR-1 is cleav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4253b04a36fcfc8019ed61e681fd5c3
https://pubmed.ncbi.nlm.nih.gov/10535908
https://pubmed.ncbi.nlm.nih.gov/10535908