Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Annette Hohaus"'
Autor:
Eugen Timin, Stanislav Andranovits, Stanislav Beyl, Eva-Maria Zangerl-Plessl, Steffen Hering, Annette Hohaus
Publikováno v:
Pflugers Archiv
Tuned calcium entry through voltage-gated calcium channels is a key requirement for many cellular functions. This is ensured by channel gates which open during membrane depolarizations and seal the pore at rest. The gating process is determined by di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7007384e7a78b7c64766c5392adadf08
https://doi.org/10.1007/s00424-018-2163-7
https://doi.org/10.1007/s00424-018-2163-7
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 468:1895-1907
In order to specify the role of individual S4 segments in CaV1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16075a30b6dffeb41cce53176e793c8f
https://doi.org/10.1007/s00424-016-1895-5
https://doi.org/10.1007/s00424-016-1895-5
Autor:
Steffen Hering, Annette Hohaus, Stanislav Andranovits, Stanislav Beyl, Eva-Maria Zangerl-Plessl, Eugen Timin
Publikováno v:
Pflugers Archiv
Inactivation of L-type calcium channel (Cav1.2) is an important determinant of the length of the cardiac action potential. Here, we report a key role of the voltage-sensing segment IS4 in Cav1.2 inactivation. Neutralization of IS4 charges gradually s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41587ba4683132ea1064c520cdbd16e9
https://doi.org/10.1007/s00424-017-2038-3
https://doi.org/10.1007/s00424-017-2038-3
Autor:
Annette Hohaus
Publikováno v:
Der Körper in der Individualpsychologie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28766e01de84f43746c9e93abeb5daa1
https://doi.org/10.30820/9783837973273-107
https://doi.org/10.30820/9783837973273-107
Publikováno v:
Pflugers Archiv
In order to specify the role of individual S4 segments in CaV1.2 gating, charged residues of segments IS4-IVS4 were replaced by glutamine and the corresponding effects on activation/deactivation of calcium channel currents were analysed. Almost all r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32f29e6001a18f07b59f14151042c924
https://pubmed.ncbi.nlm.nih.gov/27796578
https://pubmed.ncbi.nlm.nih.gov/27796578
Autor:
Steffen Hering, Eugen Timin, Anna Stary-Weinzinger, Katrin Depil, Annette Hohaus, Stanislav Beyl
Publikováno v:
The Journal of Biological Chemistry
The Timothy syndrome mutations G402S and G406R abolish inactivation of Ca(V)1.2 and cause multiorgan dysfunction and lethal arrhythmias. To gain insights into the consequences of the G402S mutation on structure and function of the channel, we systema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d970037fb16ed0096bb711edff93fa
https://doi.org/10.1074/jbc.m111.255273
https://doi.org/10.1074/jbc.m111.255273
Autor:
Eugen Timin, Waheed Shabbir, Annette Hohaus, Steffen Hering, Denise Schellmann, GH Hockerman, Thomas Erker, Stanislav Beyl
Publikováno v:
British Journal of Pharmacology. 162:1074-1082
BACKGROUND AND PURPOSE Diltiazem inhibits CaV1.2 channels and is widely used in clinical practice to treat cardiovascular diseases. Binding determinants for diltiazem are located on segments IIIS6, IVS6 and the selectivity filter of the pore forming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::144f842a2e5b3610e71b043c1f078b4a
https://doi.org/10.1111/j.1476-5381.2010.01091.x
https://doi.org/10.1111/j.1476-5381.2010.01091.x
Autor:
Stanislav Beyl, Anna Stary-Weinzinger, Michaela Kudrnac, Steffen Hering, Annette Hohaus, Waheed Shabbir, Eugen Timin, Katrin Depil
Publikováno v:
Pflugers Archiv
Single point mutations in pore-forming S6 segments of calcium channels may transform a high-voltage-activated into a low-voltage-activated channel, and resulting disturbances in calcium entry may cause channelopathies (Hemara-Wahanui et al., Proc Nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ea469ef386d340ad41e4e67b6ffe29
http://europepmc.org/articles/PMC3016219
http://europepmc.org/articles/PMC3016219
Autor:
Steffen Hering, Philipp Kügler, Annette Hohaus, Michaela Kudrnac, Stanislav Beyl, Evgeny Timin
Publikováno v:
The Journal of General Physiology
Point mutations in pore-lining S6 segments of CaV1.2 shift the voltage dependence of activation into the hyperpolarizing direction and significantly decelerate current activation and deactivation. Here, we analyze theses changes in channel gating in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89976e5201c272680fcfbc52e7ae5c2a
https://doi.org/10.1085/jgp.200910272
https://doi.org/10.1085/jgp.200910272
Autor:
Stanislav Beyl, Steffen Hering, Anna Stary, Eugen Timin, Thomas Peterbauer, Annette Hohaus, Michaela Kudrnac
Publikováno v:
Journal of Biological Chemistry. 284:12276-12284
Voltage dependence and kinetics of Ca(V)1.2 activation are affected by structural changes in pore-lining S6 segments of the alpha(1)-subunit. Significant effects are induced by either proline or threonine substitutions in the lower third of segment I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc6e787357a0df17fb1e0d00c639c61
https://doi.org/10.1074/jbc.m808402200
https://doi.org/10.1074/jbc.m808402200