Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Annette Hayden"'
Autor:
Robert C. Walker, Stella P. Breininger, Benjamin P. Sharpe, Jack Harrington, Ian Reddin, Carmen Tse, Rushda Rajak, Annette Hayden, Saqib Rahman, Ben Grace, Fereshteh Izadi, Jonathan West, Maria Secrier, Zoë S. Walters, Matthew J.J. Rose-Zerilli, Timothy J. Underwood
Background: Esophageal adenocarcinoma (EAC) is usually resistant to cytotoxic therapies and immunotherapies have gained little traction. Cancer-associated fibroblasts (CAF) are a major stromal cell population in the EAC tumor microenvironment associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eab746f0ef5928e1daf180ab878a159
https://doi.org/10.21203/rs.3.rs-2572575/v1
https://doi.org/10.21203/rs.3.rs-2572575/v1
Autor:
Benjamin P. Sharpe, Annette Hayden, Antigoni Manousopoulou, Andrew Cowie, Robert C. Walker, Jack Harrington, Fereshteh Izadi, Stella P. Breininger, Jane Gibson, Oliver Pickering, Eleanor Jaynes, Ewan Kyle, John H. Saunders, Simon L. Parsons, Alison A. Ritchie, Philip A. Clarke, Pamela Collier, Nigel P. Mongan, David O. Bates, Kiren Yacqub-Usman, Spiros D. Garbis, Zoë Walters, Matthew Rose-Zerilli, Anna M. Grabowska, Timothy J. Underwood
The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a351ee9a2592c4c61da5611e4933256a
https://cronfa.swan.ac.uk/Record/cronfa60404/Download/60404__24492__25828aca726243bd8ebef436e97463bc.pdf
https://cronfa.swan.ac.uk/Record/cronfa60404/Download/60404__24492__25828aca726243bd8ebef436e97463bc.pdf
O29: PREDICTING RESPONSE TO NEOADJUVANT THERAPY IN OESOPHAGEAL ADENOCARCINOMA PRE-TREATMENT BIOPSIES
Autor:
Megan Lloyd, Annette Hayden, J Horne, Timothy J. Underwood, M Machado, B Grace, F Izadi, Jack Harrington, Saqib Rahman, Robert J. Walker
Publikováno v:
British Journal of Surgery. 108
Aims We currently cannot predict which patients with locally advanced oesophageal adenocarcinoma will be amongst the 15-20% to gain a clinically important response to neoadjuvant therapy (NAT). This pilot study aimed to identify differentially expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afa3e7abaf99d47728c146de170ef7e8
https://doi.org/10.1093/bjs/znab117.029
https://doi.org/10.1093/bjs/znab117.029
Autor:
Ewan Kyle, Pamela Collier, Zoë S. Walters, Anna M. Grabowska, Antigoni Manousopoulou, Benjamin P. Sharpe, Andrew Cowie, Spiros D. Garbis, Fereshteh Izadi, Robert C. Walker, Simon L. Parsons, A.A. Ritchie, Philip A. Clarke, John H. Saunders, Annette Hayden, Timothy J. Underwood, Jack Harrington, Stella P. Breininger, Matthew J. J. Rose-Zerilli
Publikováno v:
SSRN Electronic Journal.
The chemotherapy resistance of esophageal adenocarcinomas (EAC) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that by targeting the tumor-promoting functions of the predominant TME cell type, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc42783b7b92dbca0bffd1347a297d0f
https://doi.org/10.2139/ssrn.3924599
https://doi.org/10.2139/ssrn.3924599
Autor:
Spiros D. Garbis, Jack Harrington, A.A. Ritchie, John H. Saunders, Simon L. Parsons, Andrew Cowie, Annette Hayden, Benjamin P. Sharpe, Robert C. Walker, Pamela Collier, Matthew J. J. Rose-Zerilli, Fereshteh Izadi, Timothy J. Underwood, Ewan Kyle, Antigoni Manousopoulou, Anna M. Grabowska, Philip A. Clarke
Background and aimsEsophageal adenocarcinoma (EAC) is chemoresistant in the majority of cases. The tumor-promoting biology of cancer associated fibroblasts (CAF) make them a target for novel therapies. Phosphodiesterase type 5 inhibitors (PDE5i) have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2abc0610d429fcaa5613b5bae769748
https://doi.org/10.1101/2020.04.21.052647
https://doi.org/10.1101/2020.04.21.052647
Autor:
Eric Smith, Joanne P. Young, Helen M. Palethorpe, Paul A. Drew, Timothy J. Underwood, Annette Hayden
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific Reports
Oesophageal adenocarcinoma (OAC) is increasing in incidence and has a poor prognosis. Tumour derived fibroblasts (TDFs) differ functionally from normal fibroblasts (NDFs), and play a pivotal role in cancer. Many of the differences persist through sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e245680fcaf535a1a69621d10e4ea06
https://doaj.org/article/7b45679013b5435ea9c6a26671354efe
https://doaj.org/article/7b45679013b5435ea9c6a26671354efe
Autor:
Annette Hayden, Rob Walker, Jack Harrington, Lucy Kimbley, Sara Waise, Chris Hanley, Gareth Thomas, Peter Johnson, Jonathan West, Matthew JJ Rose Zerilli, TIm Underwood
A protocol to dissociate fresh esophagus tissue specimens for single-cell transcriptomics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e5721d3673bd035487c44044e0975f
https://doi.org/10.17504/protocols.io.t9ver66
https://doi.org/10.17504/protocols.io.t9ver66
Autor:
Graham Packham, M. Teresa Borrello, Sergio Regufe da Mota, Rosemary A. Strivens, Annette Hayden, Arasu Ganesan, Simon J. Crabb, Sarah G. Bailey, Hanae Benelkebir, Leon Douglas, Patrick J. Duriez
Publikováno v:
Cancer Cell International
Cancer Cell International, Vol 18, Iss 1, Pp 1-9 (2018)
Cancer Cell International, Vol 18, Iss 1, Pp 1-9 (2018)
Background Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal therapy strategies such as enzal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b584e0ffb140dcb25fa947dda38213d4
https://pubmed.ncbi.nlm.nih.gov/29760584
https://pubmed.ncbi.nlm.nih.gov/29760584
Autor:
Timothy J. Underwood, Nicholas J. Clemons, S Thirdborough, Fergus Noble, Gareth J. Thomas, Massimiliano Mellone, Annette Hayden, Mathieu Derouet, Michael J. White, Edwin Garcia, Abbie Mead, Jeremy P. Blaydes, Chudy Uzoho, John N. Primrose
Publikováno v:
The Journal of Pathology
Interactions between cancer cells and cancer-associated fibroblasts (CAF) play an important role in tumour development and progression. In this study we investigated the functional role of CAF in oesophageal adenocarcinoma (EAC). We used immunochemis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09779b0aa392cd075cdcf9dbe49f568b
http://europepmc.org/articles/PMC4312957
http://europepmc.org/articles/PMC4312957
Autor:
Maria Machado, Fereshteh Izadi, Jo Horne, B Grace, Annette Hayden, Robert J. Walker, Timothy J. Underwood, Irina Fesenko, Jack Harrington, Saqib Rahman, Megan Lloyd
Publikováno v:
European Journal of Surgical Oncology. 45:2212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994fb1e40b606494a003162af659018d
https://doi.org/10.1016/j.ejso.2019.09.071
https://doi.org/10.1016/j.ejso.2019.09.071