Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Annette Erhardt"'
Autor:
Rike Schulte, Dirk Wohlleber, Ludmilla Unrau, Bernd Geers, Christina Metzger, Annette Erhardt, Gisa Tiegs, Nico van Rooijen, Lukas C. Heukamp, Luisa Klotz, Percy A. Knolle, Linda Diehl
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2523 (2020)
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) regulates target gene expression upon ligand binding. Apart from its effects on metabolism, PPARγ activity can inhibit the production of pro-inflammatory cytokines by sev
Externí odkaz:
https://doaj.org/article/59e849378a9a4e5882795f53fac261fc
Autor:
Sabrina Sieber, Nicole Lange, Gwendlyn Kollmorgen, Annette Erhardt, Alexander Quaas, Arthur Gontarewicz, Gabriele Sass, Gisa Tiegs, Hans-Jürgen Kreienkamp
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29993 (2012)
TNFα stimulates both pro- and anti-apoptotic signalling in hepatocytes. Anti-apoptotic signalling depends on a cascade of ubiquitylation steps leading to NFκB activation. Using Sharpin-deficient mice, we show that the ubiquitin binding protein Shar
Externí odkaz:
https://doaj.org/article/e8cca8a7d502458f9feb478a47b0d242
Autor:
Bernd Geers, Lukas C. Heukamp, Annette Erhardt, Percy A. Knolle, Linda Diehl, Dirk Wohlleber, Nico van Rooijen, Gisa Tiegs, Christina Metzger, Ludmilla Unrau, Luisa Klotz, Rike Schulte
Publikováno v:
Schulte, R, Wohlleber, D, Unrau, L, Geers, B, Metzger, C, Erhardt, A, Tiegs, G, van Rooijen, N, Heukamp, L C, Klotz, L, Knolle, P A & Diehl, L 2020, ' Pioglitazone-mediated peroxisome proliferator-activated receptor γ activation aggravates murine immune-mediated hepatitis ', International Journal of Molecular Sciences, vol. 21, no. 7, 2523 . https://doi.org/10.3390/ijms21072523
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2523, p 2523 (2020)
International Journal of Molecular Sciences, 21(7):2523. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2523, p 2523 (2020)
International Journal of Molecular Sciences, 21(7):2523. Multidisciplinary Digital Publishing Institute (MDPI)
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR&gamma
) regulates target gene expression upon ligand binding. Apart from its effects on metabolism, PPAR&gamma
activity can inhibit the production of pro-inflammato
) regulates target gene expression upon ligand binding. Apart from its effects on metabolism, PPAR&gamma
activity can inhibit the production of pro-inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fab57bfecf489ec46f24a299cc06f3f
https://research.vumc.nl/en/publications/a3b5647c-0de7-4b19-ace5-fd5fd393ae87
https://research.vumc.nl/en/publications/a3b5647c-0de7-4b19-ace5-fd5fd393ae87
Autor:
Annette Erhardt, Claudia Wegscheid, Richard A. Flavell, Ulf Panzer, Gisa Tiegs, Annett Ostmann, Samuel Huber, Sonja Kapffer, Hans-Joachim Paust
Publikováno v:
Journal of the American Society of Nephrology. 24:930-942
Regulatory T cells (Tregs) exert their immunosuppressive activity through several immunoregulatory mechanisms, including the production of anti-inflammatory cytokines such as IL-10. Although several studies suggest a role for Tregs in modulating cres
Publikováno v:
Journal of Reproductive Immunology. 97:128-139
Counter-intuitively, over-the-counter medication is commonly taken by pregnant women. In this context, acetaminophen (APAP, e.g. Paracetamol, Tylenol) is generally recommended by physicians to treat fever and pain during pregnancy. Thus, APAP ranks a
Autor:
Annette Erhardt, Gisa Tiegs
Publikováno v:
Journal of Hepatology. 56(1):7-10
Acute liver failure arises from several causes including intensive alcohol abuse, viral infections, bacterial invasion, drugs, and toxins as well as foreign antigens during transplantation, and autoantigens [1]. These hepatic failures are often assoc
Autor:
Robert Fürst, Stefan Zahler, Fritz Krombach, Alexander Wolf, Markus Rehberg, Angelika M. Vollmar, Gisa Tiegs, Bettina A. Mayer, Annette Erhardt, Christoph A. Reichel, Michael Kracht
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:2240-2250
Objective— Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs par
Autor:
Johannes Herkel, Annette Erhardt, Claudia Wegscheid, Hans-Willi Mittrücker, Antonella Carambia, Benjamin Claass, Gisa Tiegs, Ulf Panzer
Publikováno v:
The Journal of Immunology. 186:5284-5293
The chemokine receptor CXCR3 is preferentially expressed by Th1 cells and critically involved in their recruitment to inflamed tissue. In a mouse model of immune-mediated liver injury inducible by Con A, we investigated the role of CXCR3 in acute IFN
Autor:
Gisa Tiegs, Annette Erhardt
Publikováno v:
Digestive Diseases. 28:86-92
Background/Aims: The liver plays an important role in immunological tolerance due to its anatomical location, as it links the gastrointestinal tract and the systemic venous circulation. Therefore, immune reactions against dietary or bacterial antigen
Autor:
Dominik Abt, Gisa Tiegs, Winfried Neuhuber, Thomas Rau, Michael Fischer, Annette Erhardt, Markus Biburger, Irena Kroeger
Publikováno v:
Journal of Hepatology. 51:342-353
Background/Aims Calcitonin gene-related peptide (CGRP) is a potent vasodilator and supposed to be responsible for neurogenic inflammation involved in migraine. Its role in inflammatory diseases of other organs is controversial and poorly investigated