Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Annette E. Patterson"'
Autor:
Ju Hee Oh, Rachel A. Cederberg, Erin Tanaka, Luisa Bopp, Terri Ser, Sara Niyyati, Annette E. Patterson, Neeku Amanat, Jared Dutra, Patricia Ye, Meredith Clark, Kirsten Ward-Hartstonge, Anne-Sophie Archambault, Janice Tsui, Philipp F. Lange, Sue Tsai, C. Bruce Verchere, Yongjin Park, Mario Fabri, Kevin L. Bennewith, Ramon I. Klein Geltink
SUMMARYCancer immunotherapy using antigen-specific CD8+T cells depends on long-lasting anti-tumor function of thein vitroexpanded T cells. T cell function is intricately linked to the activity of many metabolic pathways directly impacting the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68149a6a6b235701ee417ad837236baf
https://doi.org/10.1101/2023.03.27.533229
https://doi.org/10.1101/2023.03.27.533229
Autor:
Yi-Chun Chen, Austin J. Taylor, James M. Fulcher, Adam C. Swensen, Xiao-Qing Dai, Mitsuhiro Komba, Kenzie L.C. Wrightson, Kenny Fok, Annette E. Patterson, Ramon I. Klein-Geltink, Patrick E. MacDonald, Wei-Jun Qian, C. Bruce Verchere
Carboxypeptidase E (CPE) facilitates the conversion of prohormones into mature hormones and is highly expressed in multiple neuroendocrine tissues. Carriers ofCPEmutations have elevated plasma proinsulin and develop severe obesity and hyperglycemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3aa89041e5288a6d6c1b4079bc4debdb
https://doi.org/10.1101/2022.10.20.512925
https://doi.org/10.1101/2022.10.20.512925
Autor:
George Caputa, Mai Matsushita, David E. Sanin, Agnieszka M. Kabat, Joy Edwards-Hicks, Katarzyna M. Grzes, Roland Pohlmeyer, Michal A. Stanczak, Angela Castoldi, Jovana Cupovic, Aaron J. Forde, Petya Apostolova, Maximilian Seidl, Nikki van Teijlingen Bakker, Matteo Villa, Francesc Baixauli, Andrea Quintana, Alexandra Hackl, Lea Flachsmann, Fabian Hässler, Jonathan D. Curtis, Annette E. Patterson, Philipp Henneke, Erika L. Pearce, Edward J. Pearce
Publikováno v:
Cell Metabolism
Adipose tissue (AT) plays a central role in systemic metabolic homeostasis, but its function during bacterial infection remains unclear. Following subcutaneous bacterial infection, adipocytes surrounding draining lymph nodes initiated a transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dacb6a3f83c6d05f1337f75c1e6683
https://hdl.handle.net/21.11116/0000-000D-1585-521.11116/0000-000D-1587-3
https://hdl.handle.net/21.11116/0000-000D-1585-521.11116/0000-000D-1587-3
Autor:
David, O'Sullivan, Michal A, Stanczak, Matteo, Villa, Franziska M, Uhl, Mauro, Corrado, Ramon I, Klein Geltink, David E, Sanin, Petya, Apostolova, Nisha, Rana, Joy, Edwards-Hicks, Katarzyna M, Grzes, Agnieszka M, Kabat, Ryan L, Kyle, Mario, Fabri, Jonathan D, Curtis, Michael D, Buck, Annette E, Patterson, Annamaria, Regina, Cameron S, Field, Francesc, Baixauli, Daniel J, Puleston, Edward J, Pearce, Robert, Zeiser, Erika L, Pearce
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fever is a common symptom of infections and inflammation. We observed CD8+ T cells exposed to febrile-range temperature during activation, augmented mitochondrial mass, and metabolic activity. An adoptive transfer of these cells into tum
Autor:
Michael D. Buck, Daniel J. Puleston, Mario Fabri, Agnieszka M. Kabat, Katarzyna M. Grzes, Annamaria Regina, Michal A. Stanczak, Francesc Baixauli, Annette E. Patterson, Erika L. Pearce, Ryan Kyle, Joy Edwards-Hicks, Robert Zeiser, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, David O’Sullivan, Jonathan D. Curtis, Cameron S. Field, Edward J. Pearce, Franziska M. Uhl, Matteo Villa, Mauro Corrado, Nisha Rana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8+ T cells, exposure to febril
Autor:
Edward J. Pearce, Angela Castoldi, Joerg M. Buescher, Lea J. Flachsmann, Fabian Hässler, Ryan Kyle, Annette E. Patterson, David E. Sanin, Daniel J. Puleston, Alanna M. Cameron, Beth Kelly, Cameron S. Field, Erika L. Pearce
Publikováno v:
Nature Immunology
The adoption of Warburg metabolism is critical for the activation of macrophages in response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzy
Autor:
Jonathan D. Curtis, Petya Apostolova, Edward J. Pearce, Joerg M. Buescher, Erika L. Pearce, Annette E. Patterson, Fabian Hässler, David E. Sanin, Franziska M. Uhl, Michal A. Stanczak, David O’Sullivan, Robert Zeiser, Joy Edwards-Hicks, Nina A M Ligthart, Daniel J. Puleston, Katarzyna M. Grzes, Ramon I. Klein Geltink, Mario Fabri, Agnieszka M. Kabat
Publikováno v:
Nature Metabolism
CD8+ effector T (TE) cell proliferation and cytokine production depends on enhanced glucose metabolism. However, circulating T cells continuously adapt to glucose fluctuations caused by diet and inter-organ metabolite exchange. Here we show that tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527fdf8f9482ead8f3a9e4d7a8815d74
https://hdl.handle.net/21.11116/0000-0006-CF32-921.11116/0000-0006-CF34-7
https://hdl.handle.net/21.11116/0000-0006-CF32-921.11116/0000-0006-CF34-7
Autor:
Ramon I, Klein Geltink, Joy, Edwards-Hicks, Petya, Apostolova, David, O'Sullivan, David E, Sanin, Annette E, Patterson, Daniel J, Puleston, Nina A M, Ligthart, Joerg M, Buescher, Katarzyna M, Grzes, Agnieszka M, Kabat, Michal, Stanczak, Jonathan D, Curtis, Fabian, Hässler, Franziska M, Uhl, Mario, Fabri, Robert, Zeiser, Edward J, Pearce, Erika L, Pearce
Publikováno v:
Nature metabolism. 2(8)
CD8
Autor:
David E. Sanin, Ramon I. Klein Geltink, Jing Qiu, George Caputa, Katarzyna M. Grzes, David O’Sullivan, Alanna M. Cameron, Yaarub Musa, Jonathan D. Curtis, Stefanie Scherer, Mauro Corrado, Francesca Alfei, Beth Kelly, Mai Matsushita, Matteo Villa, Nora Pällman, Michael D. Buck, Agnieszka M. Kabat, Edward J. Pearce, Annette E. Patterson, Francesc Baixauli, Joerg M. Buescher, Gerhard Mittler, S. Kyle Austin, Dietmar Zehn, Katelyn Paz, Erika L. Pearce, Ryan Kyle, Cameron S. Field, Sabine Rospert, Lea J. Flachsmann, Ying Zhang, Daniel J. Puleston, Maria Elena Maccari, Angela Castoldi, Stefan Balabanov, Bruce R. Blazar
Publikováno v:
Cell Metabolism
Summary How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bb9061e9b120f7fcc36a04cbbe2d8c
https://hdl.handle.net/21.11116/0000-0004-A643-521.11116/0000-0006-40A4-8
https://hdl.handle.net/21.11116/0000-0004-A643-521.11116/0000-0006-40A4-8
Autor:
Eirini Trompouki, Michal A. Stanczak, Mai Azuma, Maaike Jacobs, Andrea Quintana, Katarzyna M. Grzes, Agnieszka M. Kabat, Thomas Clapes, Eve Anderson, Francesc Baixauli, Ramon I. Klein Geltink, Jonathan D. Curtis, Joy Edwards-Hicks, Lea J. Flachsmann, Edward J. Pearce, Colin G. Steward, Annette E. Patterson, Ryan Kyle, Matteo Villa, David E. Sanin, David O’Sullivan, Erika L. Pearce, Mauro Corrado, Borko Amulic, Douglas Strathdee
Publikováno v:
Cell Metabolism
Corrado, M, Edwards-Hicks, J, Villa, M, Flachsmann, L J, Sanin, D E, Jacobs, M, Baixauli, F, Stanczak, M, Anderson, E, Azuma, M, Quintana, A, Curtis, J D, Clapes, T, Grzes, K M, Kabat, A M, Kyle, R, Patterson, A E, Geltink, R K, Amulic, B, Steward, C G, Strathdee, D, Trompouki, E, O'Sullivan, D, Pearce, E J & Pearce, E L 2020, ' Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity ', Cell Metabolism, vol. 32, no. 6, pp. 981-995.e7 . https://doi.org/10.1016/j.cmet.2020.11.003
Corrado, M, Edwards-Hicks, J, Villa, M, Flachsmann, L J, Sanin, D E, Jacobs, M, Baixauli, F, Stanczak, M, Anderson, E, Azuma, M, Quintana, A, Curtis, J D, Clapes, T, Grzes, K M, Kabat, A M, Kyle, R, Patterson, A E, Geltink, R K, Amulic, B, Steward, C G, Strathdee, D, Trompouki, E, O'Sullivan, D, Pearce, E J & Pearce, E L 2020, ' Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity ', Cell Metabolism, vol. 32, no. 6, pp. 981-995.e7 . https://doi.org/10.1016/j.cmet.2020.11.003
Summary Mitochondria constantly adapt to the metabolic needs of a cell. This mitochondrial plasticity is critical to T cells, which modulate metabolism depending on antigen-driven signals and environment. We show here that de novo synthesis of the mi