Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Annette E. Neele"'
Autor:
Karl J. Harber, Annette E. Neele, Cindy PAA. van Roomen, Marion JJ. Gijbels, Linda Beckers, Myrthe den Toom, Bauke V. Schomakers, Daan AF. Heister, Lisa Willemsen, Guillermo R. Griffith, Kyra E. de Goede, Xanthe AMH. van Dierendonck, Myrthe E. Reiche, Aurélie Poli, Frida L-H Mogensen, Alessandro Michelucci, Sanne GS. Verberk, Helga de Vries, Michel van Weeghel, Jan Van den Bossche, Menno PJ. de Winther
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103054- (2024)
Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be
Externí odkaz:
https://doaj.org/article/7cec2f81eb784b929ea89dd94752aa37
Autor:
Julie Rondeaux, Déborah Groussard, Sylvanie Renet, Virginie Tardif, Anaïs Dumesnil, Alphonse Chu, Léa Di Maria, Théo Lemarcis, Manon Valet, Jean-Paul Henry, Zina Badji, Claire Vézier, Delphine Béziau-Gasnier, Annette E. Neele, Menno P. J. de Winther, Dominique Guerrot, Marjorie Brand, Vincent Richard, Eric Durand, Ebba Brakenhielm, Sylvain Fraineau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Epigenetic regulation of histone H3K27 methylation has recently emerged as a key step during alternative immunoregulatory M2-like macrophage polarization; known to impact cardiac repair after Myocardial Infarction (MI). We hypothesized that
Externí odkaz:
https://doaj.org/article/c73ad8d8e7874795be8b6aa46ecf3ac0
Autor:
Jeroen Baardman, Sanne G. S. Verberk, Saskia van der Velden, Marion J. J. Gijbels, Cindy P. P. A. van Roomen, Judith C. Sluimer, Jelle Y. Broos, Guillermo R. Griffith, Koen H. M. Prange, Michel van Weeghel, Soufyan Lakbir, Douwe Molenaar, Elisa Meinster, Annette E. Neele, Gijs Kooij, Helga E. de Vries, Esther Lutgens, Kathryn E. Wellen, Menno P. J. de Winther, Jan Van den Bossche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages res
Externí odkaz:
https://doaj.org/article/2c0a011d044046398f11e576a0b58fa9
Autor:
Lisa Willemsen, Hung-Jen Chen, Cindy P. A. A. van Roomen, Guillermo R. Griffith, Ricky Siebeler, Annette E. Neele, Jeffrey Kroon, Marten A. Hoeksema, Menno P. J. de Winther
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential role in antiviral responses and inflammatory activat
Externí odkaz:
https://doaj.org/article/69458ffd899140378f46c0bb4e3955bd
Autor:
Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans, Menno P. J. de Winther
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Background Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epigenetic remodeling whe
Externí odkaz:
https://doaj.org/article/5ccb0cea0ba542819cf607b568f93f16
Autor:
Annette E. Neele, Hung-Jen Chen, Marion J. J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C. S. Boshuizen, Jan Van den Bossche, Anton T. Tool, Hanke L. Matlung, Timo K. van den Berg, Esther Lutgens, Menno P. J. de Winther
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Macrophages define a key component of immune cells present in atherosclerotic lesions and are central regulators of the disease. Since epigenetic processes are important in controlling macrophage function, interfering with epigenetic pathways in macr
Externí odkaz:
https://doaj.org/article/a428a6da91984e6f8be4eb28adb8b03a
Autor:
Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate p
Externí odkaz:
https://doaj.org/article/0bd1c20ec87342d695539812e636ba12
Autor:
Jeroen Baardman, Sanne G.S. Verberk, Koen H.M. Prange, Michel van Weeghel, Saskia van der Velden, Dylan G. Ryan, Rob C.I. Wüst, Annette E. Neele, Dave Speijer, Simone W. Denis, Maarten E. Witte, Riekelt H. Houtkooper, Luke A. O’neill, Elena V. Knatko, Albena T. Dinkova-Kostova, Esther Lutgens, Menno P.J. de Winther, Jan Van den Bossche
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Summary: Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immune
Externí odkaz:
https://doaj.org/article/d4969ea3a1584cdbbc7e5b1d85f55612
Autor:
Jan Van den Bossche, Jeroen Baardman, Natasja A. Otto, Saskia van der Velden, Annette E. Neele, Susan M. van den Berg, Rosario Luque-Martin, Hung-Jen Chen, Marieke C.S. Boshuizen, Mohamed Ahmed, Marten A. Hoeksema, Alex F. de Vos, Menno P.J. de Winther
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 684-696 (2016)
Macrophages are innate immune cells that adopt diverse activation states in response to their microenvironment. Editing macrophage activation to dampen inflammatory diseases by promoting the repolarization of inflammatory (M1) macrophages to anti-inf
Externí odkaz:
https://doaj.org/article/fa408860cfc742feaf109656fe022033
Autor:
Sam J. L. van der Tuin, Zhuang Li, Jimmy F. P. Berbée, Inge Verkouter, Linda E. Ringnalda, Annette E. Neele, Jan B. van Klinken, Sander S. Rensen, Jingyuan Fu, Menno P. J. de Winther, Albert K. Groen, Patrick C. N. Rensen, Ko Willems van Dijk, Yanan Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 6 (2018)
BackgroundLipopolysaccharide (LPS) decreases hepatic CETP (cholesteryl ester transfer protein) expression albeit that the underlying mechanism is disputed. We recently showed that plasma CETP is mainly derived from Kupffer cells (KCs). In this study,
Externí odkaz:
https://doaj.org/article/96cebfc1837d49748338f60c362051ae