Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Annette E Neele"'
Autor:
Marten A Hoeksema, Marion JJ Gijbels, Jan Van den Bossche, Saskia van der Velden, Ayestha Sijm, Annette E Neele, Tom Seijkens, J Lauran Stöger, Svenja Meiler, Marieke CS Boshuizen, Geesje M Dallinga‐Thie, Johannes HM Levels, Louis Boon, Shannon E Mullican, Nathanael J Spann, Jack P Cleutjens, Chris K Glass, Mitchell A Lazar, Carlie JM de Vries, Erik AL Biessen, Mat JAP Daemen, Esther Lutgens, Menno PJ de Winther
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 9, Pp 1124-1132 (2014)
Abstract Macrophages are key immune cells found in atherosclerotic plaques and critically shape atherosclerotic disease development. Targeting the functional repertoire of macrophages may hold novel approaches for future atherosclerosis management. H
Externí odkaz:
https://doaj.org/article/c1022f732a3f48b2bc9b04afedbfc806
Autor:
Jeroen Baardman, Sanne G. S. Verberk, Saskia van der Velden, Marion J. J. Gijbels, Cindy P. P. A. van Roomen, Judith C. Sluimer, Jelle Y. Broos, Guillermo R. Griffith, Koen H. M. Prange, Michel van Weeghel, Soufyan Lakbir, Douwe Molenaar, Elisa Meinster, Annette E. Neele, Gijs Kooij, Helga E. de Vries, Esther Lutgens, Kathryn E. Wellen, Menno P. J. de Winther, Jan Van den Bossche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages res
Externí odkaz:
https://doaj.org/article/2c0a011d044046398f11e576a0b58fa9
Autor:
Lisa Willemsen, Hung-Jen Chen, Cindy P. A. A. van Roomen, Guillermo R. Griffith, Ricky Siebeler, Annette E. Neele, Jeffrey Kroon, Marten A. Hoeksema, Menno P. J. de Winther
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Macrophages are critical components of atherosclerotic lesions and their pro- and anti-inflammatory responses influence atherogenesis. Type-I interferons (IFNs) are cytokines that play an essential role in antiviral responses and inflammatory activat
Externí odkaz:
https://doaj.org/article/69458ffd899140378f46c0bb4e3955bd
Autor:
Koen F. Dekkers, Annette E. Neele, J. Wouter Jukema, Bastiaan T. Heijmans, Menno P. J. de Winther
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Background Macrophages and their precursors monocytes play a key role in inflammation and chronic inflammatory disorders. Monocyte-to-macrophage differentiation and activation programs are accompanied by significant epigenetic remodeling whe
Externí odkaz:
https://doaj.org/article/5ccb0cea0ba542819cf607b568f93f16
Autor:
Sandro Ninni, David Dombrowicz, Tanya Kuznetsova, Rocio Vicario, Vance Gao, Olivier Molendi-Coste, Joel Haas, Eloise Woitrain, Augustin Coisne, Annette E. Neele, Koen Prange, Lisa Willemsen, Samy Aghezzaf, Stamatina Fragkogianni, Amine Tazibet, Laurent Pineau, James Robert White, Jérôme Eeckhoute, Mohamed Koussa, Henri Dubrulle, Francis Juthier, Jérôme Soquet, André Vincentelli, Jean-Louis Edme, Menno de Winther, Frederic Geissmann, Bart Staels, David Montaigne
Publikováno v:
Journal of the American College of Cardiology. 81:1263-1278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7752e8a4e87e3fc298fa7281fbbf46f
https://doi.org/10.1016/j.jacc.2023.01.036
https://doi.org/10.1016/j.jacc.2023.01.036
Autor:
Annette E. Neele, Hung-Jen Chen, Marion J. J. Gijbels, Saskia van der Velden, Marten A. Hoeksema, Marieke C. S. Boshuizen, Jan Van den Bossche, Anton T. Tool, Hanke L. Matlung, Timo K. van den Berg, Esther Lutgens, Menno P. J. de Winther
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Macrophages define a key component of immune cells present in atherosclerotic lesions and are central regulators of the disease. Since epigenetic processes are important in controlling macrophage function, interfering with epigenetic pathways in macr
Externí odkaz:
https://doaj.org/article/a428a6da91984e6f8be4eb28adb8b03a
Autor:
Rosario Luque-Martin, Jan Van den Bossche, Rebecca C. Furze, Annette E. Neele, Saskia van der Velden, Marion J.J. Gijbels, Cindy P.P.A. van Roomen, Sharon G. Bernard, Wouter J. de Jonge, Inmaculada Rioja, Rab K. Prinjha, Huw D. Lewis, Palwinder K. Mander, Menno P.J. de Winther
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate p
Externí odkaz:
https://doaj.org/article/0bd1c20ec87342d695539812e636ba12
Autor:
Jan Van den Bossche, Jeroen Baardman, Natasja A. Otto, Saskia van der Velden, Annette E. Neele, Susan M. van den Berg, Rosario Luque-Martin, Hung-Jen Chen, Marieke C.S. Boshuizen, Mohamed Ahmed, Marten A. Hoeksema, Alex F. de Vos, Menno P.J. de Winther
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 684-696 (2016)
Macrophages are innate immune cells that adopt diverse activation states in response to their microenvironment. Editing macrophage activation to dampen inflammatory diseases by promoting the repolarization of inflammatory (M1) macrophages to anti-inf
Externí odkaz:
https://doaj.org/article/fa408860cfc742feaf109656fe022033
Autor:
Jeroen Baardman, Sanne G.S. Verberk, Koen H.M. Prange, Michel van Weeghel, Saskia van der Velden, Dylan G. Ryan, Rob C.I. Wüst, Annette E. Neele, Dave Speijer, Simone W. Denis, Maarten E. Witte, Riekelt H. Houtkooper, Luke A. O’neill, Elena V. Knatko, Albena T. Dinkova-Kostova, Esther Lutgens, Menno P.J. de Winther, Jan Van den Bossche
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Summary: Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immune
Externí odkaz:
https://doaj.org/article/d4969ea3a1584cdbbc7e5b1d85f55612
Autor:
Sam J. L. van der Tuin, Zhuang Li, Jimmy F. P. Berbée, Inge Verkouter, Linda E. Ringnalda, Annette E. Neele, Jan B. van Klinken, Sander S. Rensen, Jingyuan Fu, Menno P. J. de Winther, Albert K. Groen, Patrick C. N. Rensen, Ko Willems van Dijk, Yanan Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 6 (2018)
BackgroundLipopolysaccharide (LPS) decreases hepatic CETP (cholesteryl ester transfer protein) expression albeit that the underlying mechanism is disputed. We recently showed that plasma CETP is mainly derived from Kupffer cells (KCs). In this study,
Externí odkaz:
https://doaj.org/article/96cebfc1837d49748338f60c362051ae