Výsledky vyhledávání - "Annette C. Smith"

Publikováno v: Journal of Diagnostic Medical Sonography. 28:303-306

A 48-year-old woman presented with fatigue and vaginal spotting and was subsequently diagnosed with squamous cell cancer of the cervix. Computed tomography and positron emission tomography scans suggested widespread disease including possible involve

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https://doi.org/10.1177/8756479312457592

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

Autor: Andrew D. Strand, Gregory J. Morton, Eduardo R. Lazarowski, Randell T. Libby, Victor V. Pineda, Serge Luquet, Merle L. Gilbert, Terrence F. Satterfield, Richard P. Beyer, Ian R. Sweet, Theodor K. Bammler, Patrick Weydt, Michael W. Schwartz, Albert R. La Spada, Libin Cui, Dimitri Krainc, Annette C. Smith, Anne E. Torrence, Courtney N. Easley

Publikováno v: Cell Metabolism. 4:349-362

Huntington's disease (HD) is a fatal, dominantly inherited disorder caused by polyglutamine repeat expansion in the huntingtin (htt) gene. Here, we observe that HD mice develop hypothermia associated with impaired activation of brown adipose tissue (

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https://doi.org/10.1016/j.cmet.2006.10.004

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β-synuclein modulates α-synuclein neurotoxicity by reducing α-synuclein protein expression

Autor: Bryce L. Sopher, Pornprot Limprasert, Virginia M.-Y. Lee, John Q. Trojanowski, Ian V.J. Murray, Annette C. Smith, Yuxin Fan, Albert R. La Spada

Publikováno v: Human Molecular Genetics. 15:3002-3011

Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar aggregates of alpha-synuclein in characteristic inclusions known as "Lewy bodies". As mutations altering alpha-synuclein structure or increasing alpha-synuclein expre

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https://doi.org/10.1093/hmg/ddl242

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The transcriptional apparatus of algal plastids

Autor: Saul Purton, Annette C. Smith

Publikováno v: European Journal of Phycology. 37:301-311

The plastid organelle of plants, eukaryotic algae and apicomplexan protists contains its own DNA genome (the 'plastome'). In higher plants, at least two RNA polymerases have been shown to participate in the transcription of plastid genes. The multisu

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https://doi.org/10.1017/s0967026202003694

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In vivo expansion of trinucleotide repeats yields plasmid and YAC constructs for targeting and transgenesis

Autor: Albert R. La Spada, Scott B Myrick, Julie Y Hong, Annette C. Smith, Bryce L. Sopher

Publikováno v: Gene. 261:383-390

Production of mouse models of inherited neurodegenerative diseases is an important step towards understanding the mechanism of neurotoxicity and for testing potential therapies. We are interested in creating a mouse model for X-linked spinal and bulb

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https://doi.org/10.1016/s0378-1119(00)00508-4

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Levels of dna damage are unaltered in mice overexpressing human catalase in nuclei

Autor: Annette C. Smith, Samuel E. Schriner, Terry G. Newcomb, Charles E. Ogburn, Jan Vijg, Warren C. Ladiges, Ken Ichiro Fukuchi, Martijn E.T. Dollé, George M. Martin

Publikováno v: Free Radical Biology and Medicine. 29:664-673

Two types of transgenic mice were generated to evaluate the role of hydrogen peroxide in the formation of nuclear DNA damage. One set of lines overexpresses wild-type human catalase cDNA, which is localized to peroxisomes. The other set overexpresses

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https://doi.org/10.1016/s0891-5849(00)00352-x

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Overexpression of wild-type and nuclear-targeted catalase modulates resistance to oxidative stress but does not alter spontaneous mutant frequencies at APRT

Autor: Annette C. Smith, Samuel E. Schriner, Ken Ichiro Fukuchi, Ngocthao Dang, George M. Martin

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 449:21-31

Animal cells generate hydrogen peroxide as a byproduct of energy metabolism. In the presence of reduced metals H2O2 can decompose to a highly reactive hydroxyl radical that attacks essentially all organic molecules, including DNA. We wished to determ

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https://doi.org/10.1016/s0027-5107(00)00011-7

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Trypsin inhibitor activities of fibroblasts increase with age of donor and are unaltered in familial Alzheimer's disease

Autor: Mark G. Hearn, Annette C. Smith, Ken Ichiro Fukuchi, Thomas D. Bird, George M. Martin, Steven D. Edland, Charles E. Ogburn

Publikováno v: Experimental Gerontology. 29:611-623

Increasing evidence suggests that proteases and their inhibitors play an important role in the etiology of beta-amyloidogenesis and Alzheimer's disease (AD). It is not clear, however, which proteases and protease inhibitors are responsible for the am

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https://doi.org/10.1016/0531-5565(94)90074-4

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Oxygen-resistant multipotent embryonic carcinoma cell lines exhibit antimutator phenotypes

Autor: Mitchell S. Turker, George M. Martin, Charles E. Ogburn, Terrance J. Kavanagh, Annette C. Smith, Ken Ichiro Fukuchi, Christine M. Disteche

Publikováno v: Somatic Cell and Molecular Genetics. 20:361-370

Stable, oxygen-resistant cell lines (O2R) were isolated from P19 and P19H22 (APRT hemizygote) mouse embryonic carcinoma cells by serial exposures of increasing durations to 95% O2. Neurally differentiated progeny were also oxygen-resistant. P19O2R ex

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https://doi.org/10.1007/bf02257453

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Activity assays of nine heterogeneous promoters in neural and other cultured cells

Autor: Ken Ichiro Fukuchi, Samir S. Deeb, Annette C. Smith, George M. Martin, Jun Ichi Miyazaki, Mark G. Hearn, Ngocthao Dang, Mark Bothwell

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 30:300-305

To express high levels of proteins encoded by transfected DNA constructs in a variety of cultured cells, including neuronal cells, the activities of nine different promoters were evaluated using Escherichia coli beta-galactosidase (beta-gal) (LacZ) a

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https://doi.org/10.1007/bf02631450

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