Induced hypothermia in patients with septic shock and respiratory failure (CASS):a randomised, controlled, open-label trial

Autor: Theis Skovsgaard Itenov, Maria Egede Johansen, Morten Bestle, Katrin Thormar, Lars Hein, Louise Gyldensted, Anne Lindhardt, Henrik Christensen, Stine Estrup, Henrik Planck Pedersen, Matthew Harmon, Uday Kant Soni, Silvia Perez-Protto, Nicolai Wesche, Ulrik Skram, John Asger Petersen, Thomas Mohr, Tina Waldau, Lone Musaeus Poulsen, Ditte Strange, Nicole P Juffermans, Daniel I Sessler, Else Tønnesen, Kirsten Møller, Dennis Karsten Kristensen, Alessandro Cozzi-Lepri, Jens D Lundgren, Jens-Ulrik Jensen, Jens-Ulrik Stæhr Jensen, Jens Lundgren, Susanne Illkjær, Henry Masur, Christian Torp-Pedersen, Andrew Copas, Birgit Riis Nielsen, Jesper Grarup, Jette Hansen, Kim Nielsen, Lone Valbjørn, Sanne Lauritzen, Tina Kold, Kathrine Grundahl, Rikke Hein Rasmussen, Nikolaj Wesche, Hasse Blom, Peer Eske Jensen, Tina Galle, Bente Thaarslund, Camilla Skandov, Iben Langholz, Rasmus Ehrenfried Berthelsen, Dorthe Kjær, Merete Uldbjerg, Lily Lipsius, Magaly Engsig, Rikke Helsted, Birgitte Andersen, Eigil Nygaard, Søren Strande, Aimal Khan Bangash, Peter Søe-Jensen, Hamid Tousi, Malene Tangager, Daniel Hagi-Pedersen, Rainer Karl-Heinz Gatz, Marte Kaasen Engen, Christian Åge Wamberg, Bo Westergaard, Stine Stoktoft, Rebecca Scherwin, Finn Bærentzen, Marlene Lauritzen, Frank Pott, Christina Bruun, Christian Meyhoff, Ditte Gry Strange, Dorthe Fris Palmqvist, Claus Hemmingsen, Rune Gärtner, Kai Dieter Jung, Louise La Porte, Mette Viuf, Johannes Troglauer, Silva Borovnjak, Nina Strandkjær, Claus Bretlau, Marianna Hansen, Lea Kielsgaard Zaulich, Christian Overgaard, Katja Bergenholtz, Tejs Jansen, Mette Astrup Bæk-Jensen, Monika Detlefsen, Tannie Lund Albrechtsen, Birgitte Margareta Sode, Hans Christian Boesen, Maria Thostrup, Torben Mogens Andersen, Katrine Kjelsteen, Cilia Klara Winther Kjær, Elsebeth Haunstrup, Ole Christensen, Lone Spliid, Birgitte Rasmussen, Henriette Jejlskov, Søren Borchorst, Akil Walli Raad Abdel-Wahab, Marianne Brysting, Jette Victor, Anette Stensbirk, Karen Bjerregaard, Anne Poulsen, Annette Brix Roed, Bianca Bech, Oguz Yilmaz, Sanchit Ahuja, Iman Suleiman, Rodrigo Iglesias, Olena Breum

Publikováno v: Itenov, T S, Johansen, M E, Bestle, M, Thormar, K, Hein, L, Gyldensted, L, Lindhardt, A, Christensen, H, Estrup, S, Pedersen, H P, Harmon, M, Soni, U K, Perez-Protto, S, Wesche, N, Skram, U, Petersen, J A, Mohr, T, Waldau, T, Poulsen, L M, Strange, D, Juffermans, N P, Sessler, D I, Tønnesen, E, Møller, K, Kristensen, D K, Cozzi-Lepri, A, Lundgren, J D, Jensen, J-U, Cooling and Surviving Septic Shock (CASS) Trial Collaboration & Torp-Pedersen, C 2018, ' Induced hypothermia in patients with septic shock and respiratory failure (CASS) : a randomised, controlled, open-label trial ', The Lancet. Respiratory Medicine, vol. 6, no. 3, pp. 183-192 . https://doi.org/10.1016/S2213-2600(18)30004-3
lancet. Respiratory medicine, 6(3), 183-192. Elsevier Limited
Cooling and Surviving Septic Shock (CASS) Trial Collaboration 2018, ' Induced hypothermia in patients with septic shock and respiratory failure (CASS) : a randomised, controlled, open-label trial ', The Lancet Respiratory Medicine, vol. 6, no. 3, pp. 183-192 . https://doi.org/10.1016/S2213-2600(18)30004-3
Cooling and Surviving Septic Shock (CASS) Trial Collaboration & Hägi-Pedersen, D 2018, ' Induced hypothermia in patients with septic shock and respiratory failure (CASS) : a randomised, controlled, open-label trial ', The Lancet Respiratory Medicine, vol. 6, no. 3, pp. 183-192 . https://doi.org/10.1016/S2213-2600(18)30004-3

BACKGROUND: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dy

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