Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Annette Balhorn"'
Autor:
Azzeddine Dakhama, John Prpich, Anita Oh, Erwin W. Gelfand, Anthony Joetham, Young Mok Lee, Nobuaki Miyahara, Annette Balhorn, Katsuyuki Takeda
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 177:208-218
Rationale: Severe respiratory syncytial virus (RSV) bronchiolitis has been associated with deficient IFN-γ production in humans, but the role of this cytokine in determining the outcome of reinfection is unknown. Objectives: To define the role of IF
Autor:
Karl Kossen, Toshiyuki Koya, Erwin W. Gelfand, Barry Polisky, Joseph J. Lucas, Shawn Zinnen, Tricia N. Lively, Ivan Richards, Annette Balhorn, Katsuyuki Takeda
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background RNA interference is an endogenous cellular mechanism in which short interfering RNAs (siRNAs) direct the sequence specific degradation of a target mRNA. siRNAs can be synthesized with chemical modifications to increase stability and reduce
Autor:
Toshiyuki Koya, Annette Balhorn, Azzeddine Dakhama, Christina H. Swasey, Shigeki Matsubara, Nobuaki Miyahara, Katsuyuki Takeda, Hiroyuki Matsuda, Erwin W. Gelfand
Publikováno v:
The Journal of Immunology. 179:2787-2796
CD4+ T cells, particularly Th2 cells, play a pivotal role in allergic airway inflammation. However, the requirements for interactions between CD4+ and CD8+ T cells in airway allergic inflammation have not been delineated. Sensitized and challenged OT
Autor:
Jung Won Park, Annette Balhorn, Christian Taube, Nobuaki Miyahara, Katsuyuki Takeda, Erwin W. Gelfand, Anthony Joetham, Azzeddine Dakhama
Publikováno v:
The Journal of Immunology. 175:1876-1883
Respiratory syncytial virus (RSV) infection in early life is suspected to play a role in the development of postbronchiolitis wheezing and asthma. Reinfection is common at all ages, but factors that determine the development of altered airway functio
Autor:
Nobuaki Miyahara, Christian Taube, Xu Dong Wei, Katsuyuki Takeda, Rhi Hua Fan, Anthony Joetham, Kosuke Chayama, Jung Won Park, Annette Balhorn, Alberto Alvarez, Erwin W. Gelfand, Christina H. Swasey, Taku Kodama, Azzeddine Dakhama
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 170:952-959
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis during infancy and is associated with subsequent wheezing and asthma, but the nature of this association is not fully understood. We investigated the role of RSV-specific IgE
Autor:
Donna L. Bratton, Adrian Tomkinson, Azzeddine Dakhama, Annette Balhorn, Catherine Duez, Philippe Marquillies, André-Bernard Tonnel, Erwin W. Gelfand
Publikováno v:
Journal of Allergy and Clinical Immunology. 114:820-825
Background Eosinophils play a major role in allergic airway inflammation because of their ability to release toxic mediators. In addition, they are able to migrate toward draining thoracic lymph nodes (TLNs) after intratracheal administration, where
Autor:
Christina H. Swasey, Nobuaki Miyahara, Katsuyuki Takeda, Corrie B. Allen, Charles A. Dinarello, Anthony Joetham, Soohyun Kim, Annette Balhorn, Jung Won Park, Christian Taube, Erwin W. Gelfand, Azzeddine Dakhama, Taku Kodama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 30:830-836
The role of an interleukin (IL)-1 receptor antagonist (IL-1Ra) on the development of airway hyperresponsiveness (AHR) and airway inflammation following acute O(3) exposure in mice was investigated. Exposure of C57/BL6 mice to O(3) at a concentration
Autor:
Katsuyuki Takeda, Nobuaki Miyahara, Anthony Joetham, Azzeddine Dakhama, Catherine Duez, Amanda Evans, Erwin W. Gelfand, Taku Kodama, Eun Seok Yang, Dennis R. Voelker, Annette Balhorn, Yeong Ho Rha, Christian Taube
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 168:783-789
The lung collectin surfactant protein D (SP-D) is an important component of the innate immune response but is also believed to play a role in other regulatory aspects of immune and inflammatory responses within the lung. The role of SP-D in the devel
Autor:
Anthony Joetham, Erwin W. Gelfand, Christina H. Swasey, Katsuyuki Takeda, Azzeddine Dakhama, Joan E. Loader, Nobuaki Miyahara, Hiroshi Ohnishi, Annette Balhorn, Shigeki Matsubara
The female hormone estrogen is an important factor in the regulation of airway function and inflammation, and sex differences in the prevalence of asthma are well described. Using an animal model, we determined how sex differences may underlie the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6a3055f45b148c27fda902078513e6
https://europepmc.org/articles/PMC2335333/
https://europepmc.org/articles/PMC2335333/
Autor:
Azzeddine Dakhama, Hiroyuki Matsuda, Erwin W. Gelfand, Nobuaki Miyahara, Katsuyuki Takeda, Toshiyuki Koya, Annette Balhorn, Shigeki Matsubara
Publikováno v:
The Journal of allergy and clinical immunology. 119(5)
Background IL-10 affects dendritic cell (DC) function, but the effects on airway hyperresponsiveness (AHR) and inflammation are not defined. Objective We sought to determine the importance of IL-10 in regulating DC function in allergen-induced AHR an