The gut microbiota in multiple sclerosis varies with disease activity

Autor: Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Søndergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sørensen, Stanislav D. Ehrlich, Oluf Pedersen

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)

Abstract Background Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part

Externí odkaz: https://doaj.org/article/92667d91f9624abab5f3c3539b861d21

Pregnancy-Induced Changes in microRNA Expression in Multiple Sclerosis

Autor: Helle Bach Søndergaard, Laura Airas, Jeppe Romme Christensen, Birgitte Romme Nielsen, Lars Börnsen, Annette Oturai, Finn Sellebjerg

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Pregnancy affects the disease course in multiple sclerosis (MS), particularly in the third trimester, where the relapse rate is reduced by as much as two thirds. This study aimed at identifying changes in microRNA (miRNA) and immune cell phenotypes i

Externí odkaz: https://doaj.org/article/fdaccc2c4cab4a4bad2f8912b1c7c780

Simvastatin as add-on therapy to interferon β-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled randomised phase 4 trial

Autor: Per Soelberg, Sorensen, Jan, Lycke, Juha-Pekka, Erälinna, Astrid, Edland, Xingchen, Wu, Jette Lautrup, Frederiksen, Annette, Oturai, Clas, Malmeström, Egon, Stenager, Finn, Sellebjerg, Helle Bach, Sondergaard, Taneli, Sarasoja

Publikováno v: Sellebjerg, F T, Søndergaard, H B & SIMCOMBIN Investigators 2011, ' Simvastatin as add-on therapy to interferon beta-1a for relapsing-remitting multiple sclerosis (SIMCOMBIN study) : a placebo-controlled randomized phase 4 trial ', Lancet Neurology, vol. 10, no. 8, pp. 691-701 . https://doi.org/10.1016/S1474-4422(11)70144-2

Summary Background Treatment of relapsing-remitting multiple sclerosis with interferon beta is only partly effective. We aimed to establish whether add-on of simvastatin, a statin with anti-inflammatory properties, improves this efficacy. Methods We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efd25d8db9a976eb68ceb812e1fcbed
https://pubmed.ncbi.nlm.nih.gov/21742556