Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Annette, Nicke"'
Autor:
Juan Sierra-Marquez, Lena Schaller, Lukas Sassenbach, Antonio Ramírez-Fernández, Philipp Alt, Björn Rissiek, Béla Zimmer, Johann Schredelseker, Julia Hector, Tobias Stähler, Friedrich Koch-Nolte, Claudia A. Staab-Weijnitz, Alexander Dietrich, Robin Kopp, Annette Nicke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionP2X receptors are a family of homo- and heterotrimeric cation channels gated by extracellular ATP. The P2X4 and P2X7 subunits show overlapping expression patterns and have been involved in similar physiological processes, such as pain and
Externí odkaz:
https://doaj.org/article/b55a6bb7bcc24c3691c0c6357b0bf403
Autor:
Carolina Bianchi, Beatriz Alvarez-Castelao, Álvaro Sebastián-Serrano, Caterina Di Lauro, Lucia Soria-Tobar, Annette Nicke, Tobias Engel, Miguel Díaz-Hernández
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Over recent years, increasing evidence suggests a causal relationship between neurofibrillary tangles (NFTs) formation, the main histopathological hallmark of tauopathies, including Alzheimer’s disease (AD), and the ubiquitin–
Externí odkaz:
https://doaj.org/article/05e9ea4a27894273b4d32a47838b73a1
Autor:
Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of thes
Externí odkaz:
https://doaj.org/article/42a72dde94804cbaafa23cc1ebad1ef5
Publikováno v:
eLife, Vol 12 (2023)
The large intracellular C-terminus of the pro-inflammatory P2X7 ion channel receptor (P2X7R) is associated with diverse P2X7R-specific functions. Cryo-EM structures of the closed and ATP-bound open full-length P2X7R recently identified a membrane-ass
Externí odkaz:
https://doaj.org/article/e0e3113389d14a25bbb9c77022bba525
Autor:
Carolina Pinto-Espinoza, Charlotte Guillou, Björn Rissiek, Maximilian Wilmes, Ehsan Javidi, Nicole Schwarz, Marten Junge, Friedrich Haag, Nastassia Liaukouskaya, Nicola Wanner, Annette Nicke, Catelijne Stortelers, Yossan-Var Tan, Sahil Adriouch, Tim Magnus, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an
Externí odkaz:
https://doaj.org/article/386f3b67689741c29d0bc06c088e84e7
Autor:
Yazid Mohamed Souf, Gonxhe Lokaj, Veeresh Kuruva, Yakop Saed, Delphine Raviglione, Ashraf Brik, Annette Nicke, Nicolas Inguimbert, Sébastien Dutertre
Publikováno v:
Marine Drugs, Vol 21, Iss 6, p 356 (2023)
α-Conotoxins are well-known probes for the characterization of the various subtypes of nicotinic acetylcholine receptors (nAChRs). Identifying new α-conotoxins with different pharmacological profiles can provide further insights into the physiologi
Externí odkaz:
https://doaj.org/article/7e1a299319c743619453569bfaa58feb
Autor:
Ronald Sluyter, Sahil Adriouch, Stephen J. Fuller, Annette Nicke, Reece A. Sophocleous, Debbie Watson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8225 (2023)
The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of P2X7 and helped to establish the numerous physiological and pathophysio
Externí odkaz:
https://doaj.org/article/c438b8e4d86c48c8b331049e80db42fc
Autor:
Victor Tsetlin, Yves Haufe, Valentina Safronova, Dmitriy Serov, PranavKumar Shadamarshan, Lina Son, Irina Shelukhina, Denis Kudryavtsev, Elena Kryukova, Igor Kasheverov, Annette Nicke, Yuri Utkin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Unlike most neuronal nicotinic acetylcholine receptor (nAChR) subunits, α7, α9, and α10 subunits are able to form functional homo- or heteromeric receptors without any β subunits. While the α7 subtype is widely distributed in the mammalian brain
Externí odkaz:
https://doaj.org/article/ddee6ebe968d4ca3b82ed22a5d5b98d9
Autor:
Astrid Kollewe, Vladimir Chubanov, Fong Tsuen Tseung, Leonor Correia, Eva Schmidt, Anna Rössig, Susanna Zierler, Alexander Haupt, Catrin Swantje Müller, Wolfgang Bildl, Uwe Schulte, Annette Nicke, Bernd Fakler, Thomas Gudermann
Publikováno v:
eLife, Vol 10 (2021)
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 plays a fundamental role in the cellular uptake of divalent cations such a
Externí odkaz:
https://doaj.org/article/069728908b0a4dfe9645de8e3e8aa566
Autor:
Tina Jooss, Jiong Zhang, Béla Zimmer, Tanja Rezzonico-Jost, Björn Rissiek, Penelope Felipe Pelczar, Frauke Seehusen, Friedrich Koch-Nolte, Tim Magnus, Susanna Zierler, Samuel Huber, Michael Schemann, Fabio Grassi, Annette Nicke
Publikováno v:
Mucosal Immunology. 16:180-193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5835bca35b79c06c174a766b5118997
https://doi.org/10.1016/j.mucimm.2022.11.003
https://doi.org/10.1016/j.mucimm.2022.11.003