Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Annette, Gärtner"'
Autor:
Fanomezana M. Ranaivoson, Rieke Bande, Isabell Cardaun, Antonio De Riso, Annette Gärtner, Pui Loke, Christina Reinisch, Prasuna Vogirala, Edward Beaumont
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 395-404 (2024)
Human peptidylarginine deiminase isoform VI (PAD6), which is predominantly limited to cytoplasmic lattices in the mammalian oocytes in ovarian tissue, is essential for female fertility. It belongs to the peptidylarginine deiminase (PAD) enzyme family
Externí odkaz:
https://doaj.org/article/b9751cfa701542cf81ac2d65fef67ad1
Autor:
Soraia Barão, Annette Gärtner, Eduardo Leyva-Díaz, Galina Demyanenko, Sebastian Munck, Tine Vanhoutvin, Lujia Zhou, Melitta Schachner, Guillermina López-Bendito, Patricia F. Maness, Bart De Strooper
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1367-1376 (2015)
ΒACE1 is the major drug target for Alzheimer’s disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in t
Externí odkaz:
https://doaj.org/article/ed8786a645914ceea5d53358b982e667
Autor:
Daniele Bertoglio, Jonathan Bard, Manuela Hessmann, Longbin Liu, Annette Gärtner, Stef De Lombaerde, Britta Huscher, Franziska Zajicek, Alan Miranda, Finn Peters, Frank Herrmann, Sabine Schaertl, Tamara Vasilkovska, Christopher J. Brown, Peter D. Johnson, Michael E. Prime, Matthew R. Mills, Annemie Van der Linden, Ladislav Mrzljak, Vinod Khetarpal, Yuchuan Wang, Deanna M. Marchionini, Mette Skinbjerg, Jeroen Verhaeghe, Celia Dominguez, Steven Staelens, Ignacio Munoz-Sanjuan
Publikováno v:
Science translational medicine
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT ) gene that encodes the pathologic mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract
Autor:
Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
Publikováno v:
Nature Medicine. 25:1131-1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be importa
Autor:
Gaia Elena Berto, Cristina Iobbi, Paola Camera, Elena Scarpa, Corinne Iampietro, Federico Bianchi, Marta Gai, Francesco Sgrò, Flavio Cristofani, Annette Gärtner, Carlos G Dotti, Ferdinando Di Cunto
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93721 (2014)
In neuronal cells, actin remodeling plays a well known role in neurite extension but is also deeply involved in the organization of intracellular structures, such as the Golgi apparatus. However, it is still not very clear which mechanisms may regula
Externí odkaz:
https://doaj.org/article/1ebdcfba156b44a2973e4dd01865c153
Autor:
Liesbeth Micholt, Annette Gärtner, Dimiter Prodanov, Dries Braeken, Carlos G Dotti, Carmen Bartic
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66170 (2013)
The establishment of neuronal connectivity depends on the correct initial polarization of the young neurons. In vivo, developing neurons sense a multitude of inputs and a great number of molecules are described that affect their outgrowth. In vitro,
Externí odkaz:
https://doaj.org/article/a57a6bac9dec4aab83d9f1c76e99d09c
Autor:
Joachim G. Schulz, Leen Van Huffel, Paul P. Van Veldhoven, Jarl Bastianen, Annette Gärtner, Sven Vilain, Antonio Laranjeira, Carlos G. Dotti
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports
Scientific Reports
The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view, we here sh
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24190 (2011)
Early in vitro and recent in vivo studies demonstrated that neuronal polarization occurs by the sequential formation of two oppositely located neurites. This early bipolar phenotype is of crucial relevance in brain organization, determining neuronal
Externí odkaz:
https://doaj.org/article/4a506a98021f432e9d4cf1795d3b181d
Autor:
Verena Kluever, Stefan Bonn, Vikas Bansal, Henning Urlaub, J. D. Wren, Silvio O. Rizzoli, E. Fritsch, Eugenio F. Fornasiero, Annette Gärtner, L. Caldi Gomes, Sunit Mandad, Raza-Ur Rahman, Sarva Keihani, S. Kügler
Publikováno v:
Science advances 5(12), eaay2670 (2019). doi:10.1126/sciadv.aay2670
Science Advances
Science Advances
NeuroLNC, a previously unknown long ncRNA, regulates neuronal activity by interacting with the neurodegeneration protein TDP-43.
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function a
The cellular and the molecular mechanisms by which long noncoding RNAs (lncRNAs) may regulate presynaptic function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2243aba061417eff0d84ab59446606
http://resolver.sub.uni-goettingen.de/purl?gs-1/17142
http://resolver.sub.uni-goettingen.de/purl?gs-1/17142
Autor:
Annette Gärtner, Lujia Zhou, Sebastian Munck, Guillermina López-Bendito, Galina P. Demyanenko, Melitta Schachner, Soraia Barão Lourenco Barao, Eduardo Leyva-Díaz, Tine Vanhoutvin, Patricia F. Maness, Bart De Strooper
Publikováno v:
Cell reports
Cell Reports, Vol 12, Iss 9, Pp 1367-1376 (2015)
Cell Reports, Vol 12, Iss 9, Pp 1367-1376 (2015)
ΒACE1 is the major drug target for Alzheimer’s disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in t