Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Annett Wilken-Schmitz"'
Autor:
Alexandra Vogel, Timo Ueberbach, Annett Wilken-Schmitz, Lisa Hahnefeld, Luisa Franck, Marc-Philipp Weyer, Tassilo Jungenitz, Tobias Schmid, Giulia Buchmann, Florian Freudenberg, Ralf P. Brandes, Robert Gurke, Stephan W. Schwarzacher, Gerd Geisslinger, Thomas Mittmann, Irmgard Tegeder
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-24 (2023)
Abstract Background Pain in early life may impact on development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of “early-life-pain” (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under contro
Externí odkaz:
https://doaj.org/article/1360257bc91b435c8db71bf01203a661
Autor:
Ellen Niederberger, Annett Wilken-Schmitz, Christine Manderscheid, Yannick Schreiber, Robert Gurke, Irmgard Tegeder
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12658 (2022)
Oral rotenone has been proposed as a model for Parkinson’s disease (PD) in mice. To establish the model in our lab and study complex behavior we followed a published treatment regimen. C57BL/6 mice received 30 mg/kg body weight of rotenone once dai
Externí odkaz:
https://doaj.org/article/f1cc8bcf56ed490a8429d7e54e9a7708
Autor:
Bao Ngoc Tran, Lucie Valek, Annett Wilken-Schmitz, Dominik Christian Fuhrmann, Dimitry Namgaladze, Ilka Wittig, Irmgard Tegeder
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102054- (2021)
Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a, Camk2a, as a prominent prey in a brain library. Camk2a is crucial for
Externí odkaz:
https://doaj.org/article/bfa50570eabc4019b5ac0b9f650d83b1
Autor:
Lana Schumann, Annett Wilken-Schmitz, Sandra Trautmann, Alexandra Vogel, Yannick Schreiber, Lisa Hahnefeld, Robert Gurke, Gerd Geisslinger, Irmgard Tegeder
Publikováno v:
Nutrients, Vol 13, Iss 11, p 4125 (2021)
Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary
Externí odkaz:
https://doaj.org/article/9ca860e21d8f404cb6a2e893e6c608c8
Autor:
Vanessa Kraft, Katja Schmitz, Annett Wilken-Schmitz, Gerd Geisslinger, Marco Sisignano, Irmgard Tegeder
Publikováno v:
Nutrients, Vol 13, Iss 9, p 2953 (2021)
Trehalose, a sugar from fungi, mimics starvation due to a block of glucose transport and induces Transcription Factor EB- mediated autophagy, likely supported by the upregulation of progranulin. The pro-autophagy effects help to remove pathological p
Externí odkaz:
https://doaj.org/article/fe6f7f6ac9b841aa9a105fb6074eee44
Autor:
Caroline Fischer, Annett Wilken-Schmitz, Victor Hernandez-Olmos, Ewgenij Proschak, Holger Stark, Ingrid Fleming, Andreas Weigert, Manuela Thurn, Martine Hofmann, Ernst R. Werner, Gerd Geisslinger, Ellen Niederberger, Katrin Watschinger, Irmgard Tegeder
Publikováno v:
Cells, Vol 10, Iss 5, p 1081 (2021)
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids. The present study describes the disclosure and biological character
Externí odkaz:
https://doaj.org/article/aa001c148d14400d860595c1fbc49d21
Autor:
Alexandra Vogel, Timo Ueberbach, Annett Wilken-Schmitz, Lisa Hahnefeld, Luisa Franck, Marc-Philipp Weyer, Tassilo Jungenitz, Tobias Schmid, Giulia Buchmann, Florian Freudenberg, Ralf P. Brandes, Robert Gurke, Stephan W. Schwarzacher, Gerd Geisslinger, Thomas Mittmann, Irmgard Tegeder
Pain in early life may affect cortical development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of "early-life-pain" (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under control of the Advillin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d383ead2e7cc3c8cbbaada7fedd124
https://doi.org/10.21203/rs.3.rs-2560826/v1
https://doi.org/10.21203/rs.3.rs-2560826/v1
Autor:
Irmgard Tegeder, Alexandra Vogel, Timo Ueberbach, Annett Wilken-Schmitz, Tassilo Jungenitz, Tobias Schmid, Guilia Buchmann, Ralf Brandes, Stephan Schwarzacher, Thomas Mittmann
Pain in early life may affect cortical development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of "early-life-pain" (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under control of the Advillin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22992e6198695d9de4644cbbbce01c36
https://doi.org/10.21203/rs.3.rs-2051833/v1
https://doi.org/10.21203/rs.3.rs-2051833/v1
Autor:
Yannick Schreiber, Caroline Fischer, Katja Schmitz, Dominique Thomas, Lisa Hahnefeld, Gerd Geisslinger, Sabine Wicker, Katrin Watschinger, Annett Wilken-Schmitz, Robert Gurke, Irmgard Tegeder, Ernst R. Werner, Sandra Trautmann, Robert Brunkhorst
Publikováno v:
Neurotherapeutics
Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity. Hence, the clinically avai
Autor:
Juliane Mooz, Kristina Riegel, Hari PS, Anguraj Sadanandam, Federico Marini, Matthias Klein, Ulrike Werner, Wilfried Roth, Annett Wilken-Schmitz, Irmgard Tegeder, Krishnaraj Rajalingam
Publikováno v:
Science advances. 8(11)
RAF kinases are highly conserved serine/threonine kinases, and among the three RAF isoforms (ARAF, BRAF, and CRAF), the pathophysiological relevance of ARAF is not well defined. Here, we show that patients with lung cancer exhibit low expression of A