Functional and Pharmacological Comparison of Human and Mouse Na+/Taurocholate Cotransporting Polypeptide (NTCP)

Autor: Mladen V. Tzvetkov, Yohannes Hagos, Juergen Brockmoeller, Joachim Geyer, Saskia Floerl, Annett Kuehne

Publikováno v: SLAS Discovery. 26:1055-1064

The Na+/taurocholate cotransporting polypeptide (NTCP) is located in the basolateral membrane of hepatocytes, where it transports bile acids from the portal blood back into hepatocytes. Furthermore, NTCP has a role for the hepatic transport of some d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f26aee9935a6de79d254f89bdb808380
https://doi.org/10.1177/24725552211017500

In vitro validation of an in vivo phenotyping drug cocktail for major drug transporters in humans

Autor: Chih-hsuan Hsin, Annett Kuehne, Yi Gu, Gabriele Jedlitschky, Yohannes Hagos, Dirk Gründemann, Uwe Fuhr

Publikováno v: European Journal of Pharmaceutical Sciences. 186:106459

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fea5527359fd2dfd5a6e5856a22466ce
https://doi.org/10.1016/j.ejps.2023.106459

Functional characterization and comparison of human and mouse organic anion transporter 1 as drugs and pesticides uptake carrier

Autor: Saskia, Floerl, Annett, Kuehne, Yohannes, Hagos

Publikováno v: European Journal of Pharmaceutical Sciences. 175:106217

The organic anion transporter 1 (OAT1) is mainly expressed in proximal tubule cells, where it mediates the renal uptake of endogenous and exogenous compounds. Thereby, it has enormous clinical relevance particularly in drug-drug interactions. The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19412924ccc774a6b45dfb2c6c8ddab7
https://doi.org/10.1016/j.ejps.2022.106217

Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction

Autor: Annett Kuehne, Yohannes Hagos, Saskia Floerl

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6871, p 6871 (2020)
Volume 21
Issue 18

Extrapolation from animal to human data is not always possible, because several essential factors, such as expression level, localization, as well as the substrate selectivity and affinity of relevant transport proteins, can differ between species. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982414dfd3e9e8bf326c6c91362c5f0d
https://pubmed.ncbi.nlm.nih.gov/32961667