Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Annett Kreimeyer"'
Autor:
Alain Perret, Christophe Lechaplais, Sabine Tricot, Nadia Perchat, Carine Vergne, Christine Pellé, Karine Bastard, Annett Kreimeyer, David Vallenet, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22918 (2011)
BackgroundBacteria are key components in all ecosystems. However, our knowledge of bacterial metabolism is based solely on the study of cultivated organisms which represent just a tiny fraction of microbial diversity. To access new enzymatic reaction
Externí odkaz:
https://doaj.org/article/f697af082c04491d853e25a9ad2db1d8
Autor:
David Vallenet, Patrice Nordmann, Valérie Barbe, Laurent Poirel, Sophie Mangenot, Elodie Bataille, Carole Dossat, Shahinaz Gas, Annett Kreimeyer, Patricia Lenoble, Sophie Oztas, Julie Poulain, Béatrice Segurens, Catherine Robert, Chantal Abergel, Jean-Michel Claverie, Didier Raoult, Claudine Médigue, Jean Weissenbach, Stéphane Cruveiller
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1805 (2008)
Acinetobacter baumannii is the source of numerous nosocomial infections in humans and therefore deserves close attention as multidrug or even pandrug resistant strains are increasingly being identified worldwide. Here we report the comparison of two
Externí odkaz:
https://doaj.org/article/356ae5f5beb7457f9d4110cf13c17073
Autor:
Delwood C. Collins, Peter Nickel, Zhong Yin Zhang, Annett Kreimeyer, Li Wu, Antonio R. Gagliardi, Matthias U. Kassack, Daniel F. McCain
Publikováno v:
Journal of Biological Chemistry. 279:14713-14725
Protein-tyrosine phosphatases (PTPs) are important signaling enzymes that have emerged within the last decade as a new class of drug targets. It has previously been shown that suramin is a potent, reversible, and competitive inhibitor of PTP1B and Ye
Publikováno v:
Journal of Medicinal Chemistry. 42:4394-4404
The glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor, given its potential as pharmacological target, has been thoroughly studied by structure-activity relationships, which has made possible its description in terms of spatial limits a
Publikováno v:
Nucleosides and Nucleotides. 18:995-999
The preparation of acyl adenosine 5′-triphosphates as potential membrane permeable prodrugs is presented. The interaction of myristoyl- and cholesteryloxy-carbonyl-ATP with liposomes as model membranes and the release of ATP inside these vesicles w
Publikováno v:
Journal of Receptors and Signal Transduction. 19:547-557
The glycine co-agonist binding site of the NMDA receptor is a target for the prevention and treatment of neurotoxic and neurodegenerative conditions. Until now, the interactions taking place at this site, and its structure, have been investigated by
Autor:
Philippe Marliere, Annett Kreimeyer
Publikováno v:
Nucleosides and Nucleotides. 17:2339-2350
Peptidinol adenylates were assembled by condensing the carboxyl group of N-blocked peptides with the alkylamino group of leucinol 5′ adenosine phosphodiester. The latter was prepared as protected precursor from adenosine and leucinol by phosphite c
Publikováno v:
Angewandte Chemie. 110:3013-3016
Die Aufnahme von ATP in Liposomen wurde durch Verwendung des lipophilen Derivats Cholesteryloxycarbonyl-ATP 1 erreicht. Dessen Hydrolyse im Inneren der Vesikel unter Freisetzung von ATP (siehe Schema) wurde nach pH-Wert-Anderung durch 31P-NMR-Spektro
Publikováno v:
Archiv der Pharmazie. 331:97-103
The synthesis of suramin analogues bearing a 2-phenyl-benzimidazole moiety is described. Aminoarene sulfonic acids 2a-e are acylated with 3,4-dinitrobenzoyl chloride 3 yielding the amides 4a-e which are hydrogenated to the corresponding diamines 5a-e
Autor:
Antonio R. Gagliardi, Delwood C. Collins, Matthiass Kassack, Peter Nickel, Guido Muller, Annett Kreimeyer
Publikováno v:
Cancer Chemotherapy and Pharmacology. 41:117-124
The purpose of this study was to test the ability of 70 polyanionic analogues of suramin to inhibit angiogenesis. The ID50, the dose that produced 50% inhibition of angiogenesis, was determined for suramin and each of the analogues by measuring the a