Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Annet F. Wierenga-Wolf"'
Autor:
Laurens Bogers, Hendrik J. Engelenburg, Malou Janssen, Peter-Paul A. Unger, Marie-José Melief, Annet F. Wierenga-Wolf, Cheng-Chih Hsiao, Matthew R.J. Mason, Jörg Hamann, Jamie van Langelaar, Joost Smolders, Marvin M. van Luijn
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104465- (2023)
Summary: Background: Although distinct brain-homing B cells have been identified in multiple sclerosis (MS), it is unknown how these further evolve to contribute to local pathology. We explored B-cell maturation in the central nervous system (CNS) of
Externí odkaz:
https://doaj.org/article/ab5257161bc347f88c384c428b46a61f
Autor:
Malou Janssen, Liza Rijvers, Steven C. Koetzier, Annet F. Wierenga-Wolf, Marie-José Melief, Jamie van Langelaar, Tessel F. Runia, Christianne J. M. de Groot, Rinze Neuteboom, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract In MS, pathogenic memory B cells infiltrate the brain and develop into antibody-secreting cells. Chemokine receptors not only define their brain-infiltrating capacity, but also assist in their maturation in germinal centers. How this corresp
Externí odkaz:
https://doaj.org/article/32ebd22e76a44d9db5b13828cd756796
Autor:
Liza Rijvers, Jamie van Langelaar, Laurens Bogers, Marie-José Melief, Steven C. Koetzier, Katelijn M. Blok, Annet F. Wierenga-Wolf, Helga E. de Vries, Jasper Rip, Odilia B.J. Corneth, Rudi W. Hendriks, Roland Grenningloh, Ursula Boschert, Joost Smolders, Marvin M. van Luijn
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Recent clinical trials have shown promising results for the next-generation Bruton’s tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a central role in signaling pathways that govern the development o
Externí odkaz:
https://doaj.org/article/0ecd2fa4ff9540149043120647a04a27
Autor:
Steven C. Koetzier, Jamie van Langelaar, Annet F. Wierenga-Wolf, Marie-José Melief, Kim Pol, Suzanne Musters, Erik Lubberts, Willem A. Dik, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In early multiple sclerosis (MS), an IFN-γhighGM-CSFhighIL-17low CD4+ T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central nervous system. Th17.1 cells express high levels of multidrug resistance protein 1
Externí odkaz:
https://doaj.org/article/28c97a48d5f44f019256739f1b535070
Autor:
Steven C. Koetzier, Rinze F. Neuteboom, Annet F. Wierenga-Wolf, Marie-José Melief, C. Louk de Mol, Angelique van Rijswijk, Willem A. Dik, Bieke Broux, Ronald van der Wal, Sjoerd A. A. van den Berg, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Background: Multiple sclerosis (MS) patients are protected from relapses during pregnancy and have an increased relapse risk after delivery. It is unknown how pregnancy controls disease-contributing CD4+ T helper (Th) cells and whether this differs i
Externí odkaz:
https://doaj.org/article/778b2341cf854ec3b228ec869c213250
Autor:
Steven C. Koetzier, Jamie van Langelaar, Marie-José Melief, Annet F. Wierenga-Wolf, Cato E. A. Corsten, Katelijn M. Blok, Cindy Hoeks, Bieke Broux, Beatrijs Wokke, Marvin M. van Luijn, Joost Smolders
Publikováno v:
Cells, Vol 11, Iss 10, p 1634 (2022)
The effector programs of CD8+ memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8+ memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed blood,
Externí odkaz:
https://doaj.org/article/9621a0d9da044e859945b53b22f5d3a4
Autor:
Jamie van Langelaar, J P A Samijn, Joost Smolders, Pieter A. van Doorn, Marvin M van Luijn, Theodora A Siepman, Menno C. van Zelm, Annet F Wierenga-Wolf, Caroline J.M. Luijks, Andrew I. Bell
Publikováno v:
European Journal of Immunology, 51, 626-633. Wiley-VCH Verlag
European Journal of Immunology, 51(3), 626-633. Wiley-VCH
European Journal of Immunology, 51(3), 626-633. Wiley-VCH
Epstein-Barr virus (EBV) infection of B cells is associated with increased multiple sclerosis (MS) susceptibility. Recently, we found that CXCR3-expressing B cells preferentially infiltrate the central nervous system of MS patients. In chronic virus-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a6961431d7f6307a2e6eba179debd1
https://doi.org/10.1002/eji.202048739
https://doi.org/10.1002/eji.202048739
Autor:
Marie-José Melief, Christianne J.M. de Groot, Rinze F. Neuteboom, Tessel F. Runia, Jamie van Langelaar, Marvin M van Luijn, Steven C Koetzier, Malou Janssen, Liza Rijvers, Annet F Wierenga-Wolf, Joost Smolders
Publikováno v:
Scientific Reports, 11(1):12126. Nature Publishing Group
Janssen, M, Rijvers, L, Koetzier, S C, Wierenga-Wolf, A F, Melief, M-J, van Langelaar, J, Runia, T F, de Groot, C J M, Neuteboom, R, Smolders, J & van Luijn, M M 2021, ' Pregnancy-induced effects on memory B-cell development in multiple sclerosis ', Scientific Reports, vol. 11, no. 1, 12126 . https://doi.org/10.1038/s41598-021-91655-9
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Janssen, M, Rijvers, L, Koetzier, S C, Wierenga-Wolf, A F, Melief, M-J, van Langelaar, J, Runia, T F, de Groot, C J M, Neuteboom, R, Smolders, J & van Luijn, M M 2021, ' Pregnancy-induced effects on memory B-cell development in multiple sclerosis ', Scientific Reports, vol. 11, no. 1, 12126 . https://doi.org/10.1038/s41598-021-91655-9
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
In MS, pathogenic memory B cells infiltrate the brain and develop into antibody-secreting cells. Chemokine receptors not only define their brain-infiltrating capacity, but also assist in their maturation in germinal centers. How this corresponds to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9f0639b3eee43655eb3f285f8faebd
http://www.scopus.com/inward/record.url?scp=85107502926&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85107502926&partnerID=8YFLogxK
Autor:
Joost Smolders, Marie-José Melief, Georges M. G. M. Verjans, Helga E. de Vries, Steven C Koetzier, Thierry P P van den Bosch, Annet F Wierenga-Wolf, Marvin M van Luijn, Katelijn M Blok, Jamie van Langelaar, Erik Lubberts, Theodora A Siepman, Kim Pol
Publikováno v:
Koetzier, S C, van Langelaar, J, Blok, K M, van den Bosch, T P P, Wierenga-Wolf, A F, Melief, M-J, Pol, K, Siepman, T A, Verjans, G M G M, Smolders, J, Lubberts, E, de Vries, H E & van Luijn, M M 2020, ' Brain-homing CD4+ T cells display glucocorticoid-resistant features in MS ', Neurology neuroimmunology & neuroinflammation, vol. 7, no. 6 . https://doi.org/10.1212/NXI.0000000000000894
Neurology(R) neuroimmunology & neuroinflammation, 7(6)
Neurology(R) neuroimmunology & neuroinflammation, 7(6). Lippincott Williams & Wilkins
Neurology neuroimmunology & neuroinflammation, 7(6). Lippincott Williams and Wilkins
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
Neurology(R) neuroimmunology & neuroinflammation, 7(6)
Neurology(R) neuroimmunology & neuroinflammation, 7(6). Lippincott Williams & Wilkins
Neurology neuroimmunology & neuroinflammation, 7(6). Lippincott Williams and Wilkins
Neurology® Neuroimmunology & Neuroinflammation
article-version (Version of Record) 3
ObjectiveTo study whether glucocorticoid (GC) resistance delineates disease-relevant T helper (Th) subsets that home to the CNS of patients with early MS.MethodsThe expression of key determinants of GC sensitivity, multidrug resistance protein 1 (MDR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d58c654d02b7173787d38d7abf81e5
https://research.vumc.nl/en/publications/14d18b55-e835-4563-b797-af04550a4235
https://research.vumc.nl/en/publications/14d18b55-e835-4563-b797-af04550a4235
Autor:
Jamie van Langelaar, Marie-José Melief, Annet F Wierenga-Wolf, Liza Rijvers, Beatrijs H.A. Wokke, Malou Janssen, Joost Smolders, YuYi Wong, Arlette L. Bruijstens, E Daniëlle van Pelt, Marvin M van Luijn
Publikováno v:
Brain Communications
Brain Communications, 2(2):197. Oxford University Press
Brain Communications, 2(2):197. Oxford University Press
Neuromyelitis optica spectrum disorders are a group of rare, but severe autoimmune diseases characterized by inflammation of the optic nerve(s) and/or spinal cord. Although naive B cells are considered key players by escaping central tolerance checkp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435510a8072b781ae8fdd602121f582b
http://europepmc.org/articles/PMC7714275
http://europepmc.org/articles/PMC7714275