Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Annet E. M. Blom"'
Autor:
Jonathan S. Marvin, Amol V. Shivange, Hailey J. Knox, Loren L. Looger, Henry A. Lester, Charlene H. Kim, Annet E. M. Blom, C. Fan, Timothy Gallagher, Laura Luebbert, Philip M. Borden, Bruce N. Cohen, Aaron L. Nichols, Hugo Rego Campello, Dennis A. Dougherty, Jonathan H. Wang, Zack Blumenfeld, Douglas C. Rees, Anand K. Muthusamy
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a55da369175a588f45fdc48dd3e8e5
https://doi.org/10.1101/2021.10.04.463082
https://doi.org/10.1101/2021.10.04.463082
Autor:
Irene Wuethrich, Janneke G C Peeters, Annet E M Blom, Christopher S Theile, Zeyang Li, Eric Spooner, Hidde L Ploegh, Carla P Guimaraes
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109883 (2014)
Aerolysin is a secreted bacterial toxin that perforates the plasma membrane of a target cell with lethal consequences. Previously explored native and epitope-tagged forms of the toxin do not allow site-specific modification of the mature toxin with a
Externí odkaz:
https://doaj.org/article/e7c5298442ba4a569a0e3bf5e40dec51
Publikováno v:
ACS Med Chem Lett
[Image: see text] γ-Aminobutyric acid type A (GABA(A)) receptors are key mediators of central inhibitory neurotransmission and have been implicated in several disorders of the central nervous system. Some positive allosteric modulators (PAMs) of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1626c8c239e87aba046a2597ce5e4a8
https://resolver.caltech.edu/CaltechAUTHORS:20200924-152452617
https://resolver.caltech.edu/CaltechAUTHORS:20200924-152452617
Autor:
Hugo Rego Campello, Henry A. Lester, Timothy Gallagher, Dennis A. Dougherty, Annet E. M. Blom
Publikováno v:
Blom, A E M, Campello, H R, Lester, H A, Gallagher, T & Dougherty, D A 2019, ' Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor ', Journal of the American Chemical Society, vol. 141, no. 40, pp. 15840-15849 . https://doi.org/10.1021/jacs.9b06580
Nicotinic acetylcholine receptors (nAChRs) are crucial for communication between synapses in the central nervous system. As such, they are also implicated in several neuropsychiatric and addictive diseases. Cytisine is a partial agonist of some nAChR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1d9fbd37029a3708dde9d5c245f66c
http://www.scopus.com/inward/record.url?scp=85073083156&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85073083156&partnerID=8YFLogxK
Autor:
Christopher S. Theile, Lenka Kundrat, Gunes Bozkurt, Annet E M Blom, Hidde L. Ploegh, Carla P. Guimaraes, Martin D. Witte
Publikováno v:
Nature protocols, 8(9), 1787-1799. Nature Publishing Group
Methods for site-specific modification of proteins should be quantitative and versatile with respect to the nature and size of the biological or chemical targets involved. They should require minimal modification of the target, and the underlying rea
Autor:
Jessica R. Ingram, Zeyang Li, Shalom Goldberg, Tongfei Wu, Christopher S. Theile, Hidde L. Ploegh, Annet E M Blom, Martin D. Witte, Carla P. Guimaraes, Lenka Kundrat
Publikováno v:
Nature protocols, 10(3), 508-516. Nature Publishing Group
PMC
PMC
Transpeptidation catalyzed by sortase A allows the preparation of proteins that are site-specifically and homogeneously modified with a wide variety of functional groups, such as fluorophores, PEG moieties, lipids, glycans, bio-orthogonal reactive
Autor:
Christopher S. Theile, Hidde L. Ploegh, Annet E M Blom, Carla P. Guimaraes, Martin D. Witte, Tongfei Wu
Publikováno v:
Nature protocols. 8(9)
Chimeric proteins, including bispecific antibodies, are biological tools with therapeutic applications. Genetic fusion and ligation methods allow the creation of N-to-C and C-to-N fused recombinant proteins, but not unnaturally linked N-to-N and C-to
Autor:
Christopher S. Theile, Carla P. Guimaraes, Annet E M Blom, Hidde L. Ploegh, Martin D. Witte, Lenka Kundrat
For many proteins, the N- or the C-terminus make essential contributions to substrate binding, for protein-protein interactions, or for anchoring the proteins to a membrane. In other circumstances, at least one of the termini is buried within the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87907a3fdefd5b3782a02692a8598281
https://europepmc.org/articles/PMC3941705/
https://europepmc.org/articles/PMC3941705/
Autor:
Alexei F. Kisselev, Paul P. Geurink, Annet E. M. Blom, Anne C. Mirabella, Christoph Driessen, Gijs A. van der Marel, Bogdan I. Florea, Herman S. Overkleeft, Mario van der Stelt, Wouter A. van der Linden, Elliot D. Mock, Gerjan de Bruin, Michael Groll, Nerea Gallastegui, Mathias J. Voges
Publikováno v:
Journal of medicinal chemistry
Proteasomes degrade the majority of proteins in mammalian cells by a concerted action of three distinct pairs of active sites. The chymotrypsin-like sites are targets of antimyeloma agents bortezomib and carfilzomib. Inhibitors of the trypsin-like si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c2a078f2549198bf71e12581185619
https://europepmc.org/articles/PMC3782865/
https://europepmc.org/articles/PMC3782865/
Autor:
Sascha Hoogendoorn, Gijsbert A. van der Marel, Lianne I. Willems, Annet E. M. Blom, Herman S. Overkleeft
Publikováno v:
Organic letters. 13(20)
A series of tunable pH-dependent BODIPY dyes were synthesized and further functionalized in a Knoevenagel condensation reaction with various aldehydes. In this fashion, monofunctional dyes containing an alkyne, azide, or carboxylic acid (masked as it