Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice

Autor: Bart P. F. Rutten, Annerieke S.R. Sierksma, Fred W. van Leeuwen, Laurence de Nijs, Jos Prickaerts, Govert Hoogland, Tim Vanmierlo, Harry W.M. Steinbusch, Daniel L.A. van den Hove

Publikováno v: Journal of Alzheimer's Disease, 51(3), 677-682. IOS Press

Treatment of Alzheimer's disease (AD) patients with the antidepressant fluoxetine is known to improve memory and cognitive function. However, the mechanisms underlying these effects are largely unknown. To unravel these mechanisms, we aimed to treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6171b831a3b9d29bbf2858ba9e9acc96
https://doi.org/10.3233/jad-151066

Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease

Autor: Annerieke S.R. Sierksma, Jos Prickaerts, Sebastian Sydlik, Somayeh Rostamian, Harry W.M. Steinbusch, Daniel L.A. van den Hove, Kris Rutten

Publikováno v: Neuropharmacology, 64, 124-136. Elsevier Science

Alzheimer's disease (AD) is characterized by progressive cognitive deficits and synaptic dysfunction. Over the last decade phosphodiesterase inhibitors (PDEIs) have received increasing attention as putative cognition enhancers and have been suggested

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b887f5b58a67c46aecbb1d8c7110ac
https://doi.org/10.1016/j.neuropharm.2012.06.048

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease

Autor: Harry W.M. Steinbusch, Bart P. F. Rutten, Annerieke S.R. Sierksma, Frank J.A. Dennissen, Paul J. Lucassen, Marijke A. M. Lemmens, Christoph Schmitz

Publikováno v: Brain Structure & Function
Brain Structure and Function, 216(3), 227-237. Springer Verlag
Brain Structure & Function, 216(3), 227-237. Springer

Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by amyloid plaque accumulation, intracellular tangles and neuronal loss in selective brain regions. The frontal cortex, important for executive functioning, is one of the regions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e98bac37ae35af77adea0e54b70419c
http://europepmc.org/articles/PMC3155024

Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and Induces Depressive-Like Behaviour in the C57BL/6NCrl Mouse

Autor: Annerieke S.R. Sierksma, Harry W.M. Steinbusch, Koen R D Vaessen, Eva L. van Donkelaar, Arjan Blokland, Ramón Cañete, Jodi L. Pawluski

Publikováno v: PLoS ONE
PLOS ONE, 9(10):e106960. Public Library of Science
PLoS ONE, Vol 9, Iss 10, p e106960 (2014)

Chronic stress or long-term administration of glucocorticoids disrupts the hypothalamus-pituitary-adrenal system leading to continuous high levels of glucocorticoids and insulin resistance (IR). This pre-diabetic state can eventually develop into typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75ac4acdf5e748282ec4fb32dc35279
http://europepmc.org/articles/PMC4195581

Effects of prenatal stress exposure on soluble Aβ and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice

Autor: Jochen De Vry, Annerieke S.R. Sierksma, Harry W.M. Steinbusch, Tim Vanmierlo, Jos Prickaerts, Daniel L.A. van den Hove, Marjolein Raijmakers

Publikováno v: Neurochemistry International, 61(5), 697-701. Elsevier Limited

Chronic stress and stress-related disorders, such as major depression (MD), have been shown to increase the risk for developing Alzheimer's disease (AD). Brain-derived neurotrophic factor (BDNF) has been postulated as a neurophysiological link betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89eb1f2b65b2a4b8c3250c56e6cd9b45
https://pubmed.ncbi.nlm.nih.gov/22750275