Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Annemieke Th den Boer"'
Autor:
Linda Penn, Martin White, Jaana Lindström, Annemieke Th den Boer, Ellen Blaak, Johan G Eriksson, Edith Feskens, Pirjo Ilanne-Parikka, Sirkka M Keinänen-Kiukaanniemi, Mark Walker, John C Mathers, Matti Uusitupa, Jaakko Tuomilehto
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57143 (2013)
Prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D prevention by lifestyle intervention is effective. Pragmatic scalable interventions are needed, with evidence to efficiently target and monitor such interventions. We report pooled anal
Externí odkaz:
https://doaj.org/article/5277eb41ef8041d4ab0099b4840a019d
Autor:
Bettina Weigelin, Annemieke Th. den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J. de Boer, Carl G. Figdor, Johannes Textor, Peter Friedl
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.
Externí odkaz:
https://doaj.org/article/62213730d2074330a309addcd60ee54f
Autor:
Kelly Broen, Annemieke Th den Boer, Rob J. de Boer, Carl G. Figdor, Esther Wagena, Peter Friedl, Bettina Weigelin, Johannes Textor, Harry Dolstra
SummaryCytotoxic T lymphocytes (CTL) eliminate tumor target cells in an antigen and cell-contact dependent manner. Lethal hit delivery occurs as a rapid and binary, “yes/no” process when immunogenicity is very high1–3, however in vivo CTL often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872126135328cb8ce7f28f2b79600527
Autor:
René E. M. Toes, Geertje J. D. van Mierlo, Cornelis J. M. Melief, Rienk Offringa, Marieke F. Fransen, Annemieke Th. den Boer
Publikováno v:
Cancer Research. 65:6984-6989
Modulation of the immune response by established tumors may contribute to the limited success of therapeutic vaccination for the treatment of cancer compared with vaccination in a preventive setting. We analyzed the contribution of the CD4+ T-cell po
Autor:
Hélène Dumortier, René E. M. Toes, Zita F. H. M. Boonman, Ellen I. H. van der Voort, Marieke F. Fransen, Annemieke Th. den Boer, Cornelis J. M. Melief, Geertje J. D. van Mierlo, Jan Nouta, Rienk Offringa
Publikováno v:
The Journal of Immunology. 173:6753-6759
The fate of naive CD8+ T cells is determined by the environment in which they encounter MHC class I presented peptide Ags. The manner in which tumor Ags are presented is a longstanding matter of debate. Ag presentation might be mediated by tumor cell
Autor:
Annemieke Th. den Boer, René E. M. Toes, Marieke F. Fransen, Geertje J. D. van Mierlo, Rienk Offringa, Cornelis J. M. Melief
Publikováno v:
The Journal of Immunology. 172:6074-6079
Naive T cells can be tolerized in the periphery by diverse mechanisms. However, the extent to which memory T cells are susceptible to tolerance induction is less well defined. Vaccination of mice with a minimal CTL epitope derived from human adenovir
Autor:
Marieke F. Fransen, Annemieke Th. den Boer, René E. M. Toes, Linda Diehl, Cornelis J. M. Melief, Rienk Offringa, Ellen I. H. van der Voort, Geertje J. D. van Mierlo, Paul Krimpenfort
Publikováno v:
The Journal of Immunology. 167:2522-2528
Encounter of Ag by naive T cells can lead to T cell priming as well as tolerance. The balance between immunity and tolerance is controlled by the conditions of Ag encounter and the activation status of the APC. We have investigated the rules that gov
Autor:
Pirjo Ilanne-Parikka, Edith J. M. Feskens, John C. Mathers, Martin White, Johan G. Eriksson, Matti Uusitupa, Jaakko Tuomilehto, Sirkka Keinänen-Kiukaanniemi, Ellen E. Blaak, Linda Penn, Mark Walker, Jaana Lindström, Annemieke Th den Boer
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e57143 (2013)
PLOS ONE, 8(2):e57143. Public Library of Science
PLoS ONE, 8(2)
PLoS ONE 8 (2013) 2
PLoS ONE, Vol 8, Iss 2, p e57143 (2013)
PLOS ONE, 8(2):e57143. Public Library of Science
PLoS ONE, 8(2)
PLoS ONE 8 (2013) 2
Background Prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D prevention by lifestyle intervention is effective. Pragmatic scalable interventions are needed, with evidence to efficiently target and monitor such interventions. We report
The onset and regulation of a specific immune response results from communication between T cells and antigen-presenting cells (APCs), which form molecular interactions at the site of cell-cell contact--and this is known as the immunological synapse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f15476dfdf3c311a8e64af354356836
https://www.ncbi.nlm.nih.gov/pubmed/15999094
https://www.ncbi.nlm.nih.gov/pubmed/15999094
Autor:
René E. M. Toes, Annemieke Th. den Boer, Marieke F. Fransen, Geertje J. D. van Mierlo, Ellen I. H. van der Voort, Jan Paul Medema, Cornelis J. M. Melief, Rienk Offringa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 99(8), 5561-5566. National Academy of Sciences
Adequate spontaneous activation of tumor-specific T lymphocytes in tumor-bearing hosts is rare, despite the expression of tumor antigens that are potentially highly immunogenic. For example, failure of the immune system to raise competent responses a