Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Annemieke T. van der Goot"'
Publikováno v:
Trends in Molecular Medicine
Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6c68272d2a921d7376834c66716915
https://doi.org/10.1016/j.molmed.2013.02.007
https://doi.org/10.1016/j.molmed.2013.02.007
Autor:
Ellen A. A. Nollen, Jasper Krijnen, Mariana Ruiz Silva, Rafael P. Vázquez-Manrique, R.C. Buijsman, Helen Michels, Annemieke T. van der Goot, Peter J. Oefner, Christian Neri, Renée I. Seinstra, Francesca Farina, Ronald Melki, Karen L. Thijssen, Wentao Zhu, Katja Dettmer, Ido P. Kema
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. ⟨10.1073/pnas.1203083109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. 〈10.1073/pnas.1203083109〉
Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. ⟨10.1073/pnas.1203083109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (37), pp.14912-7. 〈10.1073/pnas.1203083109〉
Proceedings of the National Academy of Sciences of the United States of America, 109(37), 14912-14917. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences
Toxicity of aggregation-prone proteins is thought to play an important role in aging and age-related neurological diseases like Parkinson and Alzheimer’s diseases. Here, we identify tryptophan 2,3-dioxygenase ( tdo-2 ), the first enzyme in the kynu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee9dc94f96d044482894a0fa83fcbe4
https://research.rug.nl/en/publications/4459a413-b2a0-4eb2-b6a3-d7ebfd1d1584
https://research.rug.nl/en/publications/4459a413-b2a0-4eb2-b6a3-d7ebfd1d1584
Autor:
Rogier Burggraaff, Petra van Bergeijk, Deguo Du, Jeroen van Rheenen, Annemieke T. van der Goot, Marit Wiersma, Tjakko J. van Ham, Robert M.W. Hofstra, Mats A. Holmberg, Ellen A. A. Nollen, G. Jerre van Veluw, Moisés García-Arencibia, Karen L. Thijssen, David C. Rubinsztein, Eva Teuling, Hyun Eui Kim
Publikováno v:
Cell, 142(4), 601-612. CELL PRESS
SummaryFibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders. These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-beta in Alzheimer's dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb1426400fb280f694bb6f8f8bb7759
Publikováno v:
Molecular Cell. 70:516-530.e6
Summary Glycoproteins engaged in unproductive folding in the ER are marked for degradation by a signal generated by progressive demannosylation of substrate N-glycans that is decoded by ER lectins, but how the two lectins, OS9 and XTP3B, contribute t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cbd18466e967b7adeb20f31a609cf5
https://doi.org/10.1016/j.molcel.2018.03.026
https://doi.org/10.1016/j.molcel.2018.03.026
Autor:
Cintia Roodveldt, August Andersson, Tjakko J. van Ham, Shang-Te Hsu, David Pozo, John Christodoulou, Annemieke T. van der Goot, Carlos W. Bertoncini, Jannie de Jong, Christopher M. Dobson, Rafael Fernandez-Montesinos, Ellen A. A. Nollen
Publikováno v:
EMBO Journal, 28(23), 3758-3770. Wiley
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
13 páginas, 6 figuras.-- et al.
The ATP-dependent protein chaperone heat-shock protein 70 (Hsp70) displays broad anti-aggregation functions and has a critical function in preventing protein misfolding pathologies. According to in vitro and in v
The ATP-dependent protein chaperone heat-shock protein 70 (Hsp70) displays broad anti-aggregation functions and has a critical function in preventing protein misfolding pathologies. According to in vitro and in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34c2a066d24c590b57ff45e0ee7cdb1
https://doi.org/10.1038/emboj.2009.298
https://doi.org/10.1038/emboj.2009.298
Autor:
Ellen A. A. Nollen, Jeremy N. Skepper, Gabriele S. Kaminski Schierle, Carlos W. Bertoncini, Simon Schlachter, Stefanie Schwedler, Tjakko J. van Ham, Alessandro Esposito, Janet R. Kumita, Clemens F. Kaminski, Fiona T. S. Chan, Annemieke T. van der Goot, Christopher M. Dobson
Publikováno v:
Chemphyschem, 12(3), 673-680. WILEY-V C H VERLAG GMBH
Misfolding and aggregation of amyloidogenic polypeptides lie at the root of many neurodegenerative diseases. Whilst protein aggregation can be readily studied in vitro by established biophysical techniques, direct observation of the nature and kineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40a9f6be4d3fa117522ceca9ebf64fa
https://europepmc.org/articles/PMC5402868/
https://europepmc.org/articles/PMC5402868/
In search for an appropriate model to study the role of MYO5B in apical membrane protein trafficking
Autor:
Annemieke T. van der Goot, Sven C.D. van IJzendoorn, Klaas A. Sjollema, Katarina Mackovicova, Ellen A. A. Nollen
Publikováno v:
The FASEB Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28a6a73140601ace56a15c74f8d109f1
https://doi.org/10.1096/fasebj.24.1_supplement.506.1
https://doi.org/10.1096/fasebj.24.1_supplement.506.1