Breast cancer genomics and immuno-oncological markers to guide immune therapies

Autor: Reno Debets, Stefan Sleijfer, Dora Hammerl, Marcel Smid, Annemieke M. Timmermans, John W.M. Martens

Publikováno v: Seminars in Cancer Biology, 52, 178-188. Academic Press

There is an increasing awareness of the importance of tumor - immune cell interactions to the evolution and therapy responses of breast cancer (BC). Not surprisingly, numerous studies are currently assessing the clinical value of immune modulation fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414604cc36e9bc67b46bc3cd31b00924
https://pure.eur.nl/en/publications/29a51d0f-d951-435c-a7b2-cffa53747a75

High protein expression of EZH2 is related to unfavorable outcome to tamoxifen in metastatic breast cancer

Autor: C.H.M. van Deurzen, Esther A. Reijm, Jwm Martens, M.E. Meijer-van Gelder, J.A. Foekens, M.P.H.M. Jansen, Annemieke M. Timmermans, P.M.J.J. Berns, Stefan Sleijfer, M.P. Look, Claudia Stobbe

Publikováno v: Annals of Oncology, 25(11), 2185-2190. Elsevier Ltd.

In MBC, increased mRNA levels of Enhancer of Zeste Homolog 2 (EZH2) have been shown to be associated with worse outcome to tamoxifen therapy. We confirm this association on protein expression level in an independent cohort of patients. This suggests

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32be5245db1c4447c5a47941ba1944d7
https://doi.org/10.1093/annonc/mdu391

Detection of circulating tumor cells in breast cancer may improve through enrichment with anti-CD146

Autor: Joan Bolt-de Vries, Petra van der Spoel, Mieke Schutte, John W.M. Martens, Jaco Kraan, John A. Foekens, Anieta M. Sieuwerts, Jan-Willem Gratama, Bianca Mostert, Annemieke M. Timmermans, Stefan Sleijfer, Renée Foekens

Publikováno v: Breast Cancer Research and Treatment, 127(1), 33-41. Springer New York

Most assays to detect circulating tumor cells (CTCs) rely on EpCAM expression on tumor cells. Recently, our group reported that in contrast to other molecular breast cancer subtypes, "normal-like" cell lines lack EpCAM expression and are thus missed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5767fc7f7fd987e44ac096a9502da562
https://doi.org/10.1007/s10549-010-0879-y

The prevalence of CD146 expression in breast cancer subtypes and its relation to outcome

Autor: John A. Foekens, E. Oomen-de Hoop, M. E. Meijer van Gelder, I.E. de Kruijff, Renée Foekens, Marcel Smid, A.M.A.C. Trapman, A Fat Hollestelle, Stefan Sleijfer, Annemieke M. Timmermans, M A den Bakker, A. Tjon, C.H.M. van Deurzen, Jwm Martens

Publikováno v: Annals of Oncology. 28:v61

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa064c32550f5b71b723379d6a7d42a4
https://doi.org/10.1093/annonc/mdx362.048

Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response

Autor: Renée Foekens, Maxime P. Look, Fred C.G.J. Sweep, Julie Benedicte Brask, Anita M. A. C. Trapman-Jansen, Paul N. Span, Reno Debets, Robin Beekhof, Tommaso De Marchi, Carolien H.M. van Deurzen, Vera Timmermans-Wielenga, John A. Foekens, Ning Qing Liu, John W.M. Martens, Annemieke M. Timmermans, Arzu Umar

Publikováno v: Molecular & Cellular Proteomics, 13, 1814-27
Molecular & Cellular Proteomics, 13(7), 1814-1827. American Society for Biochemistry and Molecular Biology Inc.
Molecular & Cellular Proteomics, 13, 7, pp. 1814-27
Molecular & Cellular Proteomics : MCP

Item does not contain fulltext Ferritin heavy chain (FTH1) is a 21-kDa subunit of the ferritin complex, known for its role in iron metabolism, and which has recently been identified as a favorable prognostic protein for triple negative breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3551aa93665c17d55950762bb8e703
https://doi.org/10.1074/mcp.M113.037176