Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Annemieke Kavelaars"'
Autor:
Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-18 (2023)
Highlights • Cisplatin accelerates formation of tau deposits in entorhinal cortex and hippocampus of older female and male mice. • Nasal administration of MSC after cisplatin prevents formation of tau deposits in the brain. • Tau deposits are a
Externí odkaz:
https://doaj.org/article/fefcbd1c7c8f45ca871d07b0cc6694ed
Publikováno v:
Biology Open, Vol 12, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/2d750cc0bd3e466384866b2d925be77f
Autor:
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities. We invest
Externí odkaz:
https://doaj.org/article/5b44d6910ee840eebed105fd78d879a2
Autor:
Angie C. A. Chiang, Alexandre V. Seua, Pooja Singhmar, Luis D. Arroyo, Rajasekaran Mahalingam, Jian Hu, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality of life of an increasing number of cancer survivors. The underlying
Externí odkaz:
https://doaj.org/article/033168cd016a49eb8c3097d800f1b85f
Autor:
Susmita K. Singh, Karen Krukowski, Geoffroy O. Laumet, Drew Weis, Jenolyn F. Alexander, Cobi J. Heijnen, Annemieke Kavelaars
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Understanding the endogenous mechanisms regulating resolution of pain may identify novel targets for treatment of chronic pain. Resolution of chemotherapy-induced peripheral neuropathy (CIPN) after treatment completion depends on CD8+ T cells and on
Externí odkaz:
https://doaj.org/article/b4b6582800e64046b270994c31a1808b
Autor:
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in
Externí odkaz:
https://doaj.org/article/25ca49647ebc4517838833a5d4c7449b
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NS
Externí odkaz:
https://doaj.org/article/845a280e59e6419aad823edc919c7e13
Publikováno v:
Neurobiology of Pain, Vol 7, Iss , Pp - (2020)
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia, spont
Externí odkaz:
https://doaj.org/article/c2df184179964210be6fc7fa423eab40
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Chemotherapy-induced cognitive impairment (CICI) is a commonly reported neurotoxic side effect of chemotherapy, occurring in up to 75% cancer patients. CICI manifests as decrements in working memory, executive functioning, attention, and pro
Externí odkaz:
https://doaj.org/article/cc4a32c0d62a499186d1862e0a6fde94
Autor:
Geoffroy Laumet, Jiacheng Ma, Alfred J. Robison, Susmita Kumari, Cobi J. Heijnen, Annemieke Kavelaars
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
The immune system is critically involved in the development and maintenance of chronic pain. However, T cells, one of the main regulators of the immune response, have only recently become a focus of investigations on chronic pain pathophysiology. Eme
Externí odkaz:
https://doaj.org/article/bbad8f1532254bdbb5ef621eede3c232