Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Annemieke, Kavelaars"'
Autor:
Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-18 (2023)
Highlights • Cisplatin accelerates formation of tau deposits in entorhinal cortex and hippocampus of older female and male mice. • Nasal administration of MSC after cisplatin prevents formation of tau deposits in the brain. • Tau deposits are a
Externí odkaz:
https://doaj.org/article/fefcbd1c7c8f45ca871d07b0cc6694ed
Publikováno v:
Biology Open, Vol 12, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/2d750cc0bd3e466384866b2d925be77f
Autor:
Anand Kumar Singh, Rajasekaran Mahalingam, Silvia Squillace, Kenneth A. Jacobson, Dilip K. Tosh, Shruti Dharmaraj, Susan A. Farr, Annemieke Kavelaars, Daniela Salvemini, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Cisplatin is used to combat solid tumors. However, patients treated with cisplatin often develop cognitive impairments, sensorimotor deficits, and peripheral neuropathy. There is no FDA-approved treatment for these neurotoxicities. We invest
Externí odkaz:
https://doaj.org/article/5b44d6910ee840eebed105fd78d879a2
Autor:
Angie C. A. Chiang, Alexandre V. Seua, Pooja Singhmar, Luis D. Arroyo, Rajasekaran Mahalingam, Jian Hu, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality of life of an increasing number of cancer survivors. The underlying
Externí odkaz:
https://doaj.org/article/033168cd016a49eb8c3097d800f1b85f
Autor:
Susmita K. Singh, Karen Krukowski, Geoffroy O. Laumet, Drew Weis, Jenolyn F. Alexander, Cobi J. Heijnen, Annemieke Kavelaars
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Understanding the endogenous mechanisms regulating resolution of pain may identify novel targets for treatment of chronic pain. Resolution of chemotherapy-induced peripheral neuropathy (CIPN) after treatment completion depends on CD8+ T cells and on
Externí odkaz:
https://doaj.org/article/b4b6582800e64046b270994c31a1808b
Autor:
Krystal English, Andrew Shepherd, Ndidi-Ese Uzor, Ronnie Trinh, Annemieke Kavelaars, Cobi J. Heijnen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used chemotherapeutic, induces neuronal mitochondrial dysfunction in vivo and in
Externí odkaz:
https://doaj.org/article/25ca49647ebc4517838833a5d4c7449b
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NS
Externí odkaz:
https://doaj.org/article/845a280e59e6419aad823edc919c7e13
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Chemotherapy-induced cognitive impairment (CICI) is a commonly reported neurotoxic side effect of chemotherapy, occurring in up to 75% cancer patients. CICI manifests as decrements in working memory, executive functioning, attention, and pro
Externí odkaz:
https://doaj.org/article/cc4a32c0d62a499186d1862e0a6fde94
Autor:
Timothy A. Yap, Naval Daver, Mikhila Mahendra, Jixiang Zhang, Carlos Kamiya-Matsuoka, Funda Meric-Bernstam, Hagop M. Kantarjian, Farhad Ravandi, Meghan E. Collins, Maria Emilia Di Francesco, Ecaterina E. Dumbrava, Siqing Fu, Sisi Gao, Jason P. Gay, Sonal Gera, Jing Han, David S. Hong, Elias J. Jabbour, Zhenlin Ju, Daniel D. Karp, Alessia Lodi, Jennifer R. Molina, Natalia Baran, Aung Naing, Maro Ohanian, Shubham Pant, Naveen Pemmaraju, Prithviraj Bose, Sarina A. Piha-Paul, Jordi Rodon, Carolina Salguero, Koji Sasaki, Anand K. Singh, Vivek Subbiah, Apostolia M. Tsimberidou, Quanyun A. Xu, Musa Yilmaz, Qi Zhang, Yuan Li, Christopher A. Bristow, Meenakshi B. Bhattacharjee, Stefano Tiziani, Timothy P. Heffernan, Christopher P. Vellano, Philip Jones, Cobi J. Heijnen, Annemieke Kavelaars, Joseph R. Marszalek, Marina Konopleva
Publikováno v:
Nature Medicine. 29:115-126
Publikováno v:
Neurobiology of Pain, Vol 7, Iss , Pp - (2020)
Background: Chronic pain and depression often co-occur. The mechanisms underlying this comorbidity are incompletely understood. Here, we investigated the role of CD3+ T cells in an inflammatory model of comorbid persistent mechanical allodynia, spont
Externí odkaz:
https://doaj.org/article/c2df184179964210be6fc7fa423eab40