Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Annemiek D. Knijnenburg"'
Autor:
Annemiek D. Knijnenburg, Mark Overhand, Varsha V. Kapoerchan, A. van Belkum, Jasper Swierstra
Publikováno v:
European Journal of Clinical Microbiology & Infectious Diseases
European Journal of Clinical Microbiology & Infectious Diseases, 35(5), 763-769. Springer-Verlag
European Journal of Clinical Microbiology & Infectious Diseases, 35(5), 763-769. Springer-Verlag
Development of new antibiotics is declining whereas antibiotic resistance is rising, heralding a post-antibiotic era. Antimicrobial peptides such as gramicidin S (GS), exclusively topically used due to its hemolytic side-effect, could still be intere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c37f83de4e5fd58f1c8a07bf3dc973
https://doi.org/10.1007/s10096-016-2595-y
https://doi.org/10.1007/s10096-016-2595-y
Autor:
E. Spalburg, A.J. de Neeling, Gijsbert M. Grotenbreg, Daan Noort, Roos H. Mars-Groenendijk, Hermen S. Overkleeft, Annemiek D. Knijnenburg, Mark Overhand, G. A. Van Der Marel
Publikováno v:
Helvetica Chimica Acta. 95:2544-2561
This article presents a series of ring-extended gramicidin S derivatives, 9-14, that have four ornithine residues as polar protonated side chains and one modified turn region containing a mono-functionalized cis-δ-oxetane, δ-furanoid, or δ-pyranoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b532d020ae0c08c196ef2165a7433920
https://doi.org/10.1002/hlca.201200497
https://doi.org/10.1002/hlca.201200497
Autor:
Daan Noort, M.J. van Raaij, Annemiek D. Knijnenburg, A.J. de Neeling, Roos H. Mars-Groenendijk, Emile Spalburg, José M. Otero, Herman S. Overkleeft, Antonio L. Llamas-Saiz, P. Keizer, Varsha V. Kapoerchan, Mark Overhand, G. A. Van Der Marel
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6059-6062
A series of gramicidin S derivatives 4-15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino acids with unaltered turn regions. These peptides were screened against human erthrocytes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c2c965e08ca04008f2834daa32239d
https://doi.org/10.1016/j.bmc.2012.08.038
https://doi.org/10.1016/j.bmc.2012.08.038
Autor:
Annemiek D. Knijnenburg, Mark Overhand, Daan Noort, Gijs A. van der Marel, Roos H. Mars-Groenendijk, Herman S. Overkleeft, Adriaan W. Tuin, José M. Otero, Antonio L. Llamas-Saiz, Albert J. de Neeling, Emile Spalburg, Mark J. van Raaij
Publikováno v:
Chemistry - A European Journal. 17:3995-4004
Monobenzylated sugar amino acids (SAAs) that differ in ether ring size (containing an oxetane, furanoid, and pyranoid ring) were synthesized and incorporated in one of the β-turn regions of the cyclo-decapeptide gramicidin S (GS). CD, NMR spectrosco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1ab9defd3a674de0c4c92adc5eed1c
https://doi.org/10.1002/chem.201002895
https://doi.org/10.1002/chem.201002895
Autor:
Roos H. Mars-Groenendijk, Varsha V. Kapoerchan, Annemiek D. Knijnenburg, Mark Overhand, Daan Noort, Herman S. Overkleeft, Gijs A. van der Marel, Emile Spalburg, Albert J. de Neeling
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8403-8409
Ring extended Gramicidin S analogues containing adamantane amino acids and six cationic residues were designed and evaluated. Systematic replacement of the hydrophobic residues with adamantane amino acids resulted in a small set of compounds with var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9720f732ec0cc00c1659eca008664a9b
https://doi.org/10.1016/j.bmc.2010.09.018
https://doi.org/10.1016/j.bmc.2010.09.018
Autor:
Herman S. Overkleeft, Daan Noort, Gijsbert M. Grotenbreg, Albert J. de Neeling, Emile Spalburg, Gijsbert A. van der Marel, Mark Overhand, Annemiek D. Knijnenburg, Roos H. Mars-Groenendijk
Publikováno v:
ChemMedChem. 4:1976-1979
(Chemical Equation Presented) A series of ring-extended gramicidin S (GS) derivatives containing furanoid sugar amino acids were evaluated. Although the extended GS derivatives have a less well-defined secondary structure as determined by NMR and CD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33c7f22703e59550c9b245426d09837
https://doi.org/10.1002/cmdc.200900379
https://doi.org/10.1002/cmdc.200900379
Autor:
Richard J. B. H. N. van den Berg, Annemiek D. Knijnenburg, Gijsbert A. van der Marel, Herman S. Overkleeft, Chris J. van Koppen, Kimberly M. Bonger, Laura H. Heitman, Cornelis Marius Timmers
Publikováno v:
ChemMedChem. 4:1189-1195
Two series of dimeric ligands for a G-protein-coupled receptor were prepared that differ by the interconnecting spacer system. Biological evaluation revealed that both dimeric series exhibit unique biological properties relative to their monomeric co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676d9571e82aaac8db9a31cd0455ca3c
https://doi.org/10.1002/cmdc.200900058
https://doi.org/10.1002/cmdc.200900058
Autor:
Annemiek D. Knijnenburg, Richard J. B. H. N. van den Berg, Julia Oosterom, Laura H. Heitman, Gijsbert A. van der Marel, Cornelis Marius Timmers, Kimberly M. Bonger, Ad P. IJzerman, Herman S. Overkleeft
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:3744-3758
The fact that GPCRs might function in a dimeric fashion is currently well accepted. For GnRHR, a GPCR that regulates gonadotropin release, there is evidence that the receptor also functions as a dimer. We here describe the design and synthesis of a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bfd5118d000ad0fcd07807cf7199a89
https://doi.org/10.1016/j.bmc.2008.01.054
https://doi.org/10.1016/j.bmc.2008.01.054
Autor:
Albert J. de Neeling, Roos H. Mars-Groenendijk, Antonio L. Llamas-Saiz, Gijs A. van der Marel, Varsha V. Kapoerchan, José M. Otero, Miquel Niamat, Emile Spalburg, Peter H. Nibbering, Herman S. Overkleeft, Annemiek D. Knijnenburg, Daan Noort, Mark Overhand, Mark J. van Raaij
Publikováno v:
Chemistry-A European Journal, 40, 16, 12174-12181
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry-A European Journal, 16(40), 12174-12181
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry-A European Journal, 16(40), 12174-12181
et al.
The cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis). Herein, we present a series of amphiphilic derivatives of GS with either two or f
The cyclic cationic antimicrobial peptide gramicidin S (GS) is an effective topical antibacterial agent that is toxic for human red blood cells (hemolysis). Herein, we present a series of amphiphilic derivatives of GS with either two or f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab705abc650e332f9baf16d39a95638e
http://resolver.tudelft.nl/uuid:c94bbca4-ca6e-44e9-84b0-3c95e8f9553d
http://resolver.tudelft.nl/uuid:c94bbca4-ca6e-44e9-84b0-3c95e8f9553d
