Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Annemarie N. Lekkerkerker"'
Autor:
Nicholas S. Jones, Smita Kshirsagar, Vishnu Mohanan, Vidya Ramakrishnan, Flavia Di Nucci, Ling Ma, Jialin Mao, Hao Ding, Sha Klabunde, Domagoj Vucic, Lin Pan, Annemarie N. Lekkerkerker, Yuan Chen, Michael E. Rothenberg
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1997-2009 (2023)
Abstract Receptor‐interacting protein 1 (RIP1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. RIP1 kinase activity mediates apoptosis and necroptosis induced by tumor necrosis factor (TNF)‐α
Externí odkaz:
https://doaj.org/article/d142bcfea4d8440d95ab3f753b2b144b
Autor:
Jordan S. Mar, Naruhisa Ota, Nick D. Pokorzynski, Yutian Peng, Allan Jaochico, Dewakar Sangaraju, Elizabeth Skippington, Annemarie N. Lekkerkerker, Michael E. Rothenberg, Man-Wah Tan, Tangsheng Yi, Mary E. Keir
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation
Externí odkaz:
https://doaj.org/article/07f3567e2214401ab5134a8634835824
Autor:
Jeffrey L. Bennett, Kazuo Fujihara, Ho Jin Kim, Romain Marignier, Kevin C. O'Connor, Robert C. Sergott, Anthony Traboulsee, Heinz Wiendl, Jens Wuerfel, Scott S. Zamvil, Veronica G. Anania, Regine Buffels, Thomas Künzel, Annemarie N. Lekkerkerker, Siân Lennon-Chrimes, Sean J. Pittock
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system that produces acute, unpredictable relapses causing cumulative neurological disability. Satralizumab, a humanized, monoclonal recycli
Externí odkaz:
https://doaj.org/article/65073f7848d74c30812b90f40057ec13
Autor:
Michael, Waters, James A, McKinnell, Andre C, Kalil, Greg S, Martin, Timothy G, Buchman, Wiebke, Theess, Xiaoying, Yang, Annemarie N, Lekkerkerker, Tracy, Staton, Carrie M, Rosenberger, Rajita, Pappu, Yehong, Wang, Wenhui, Zhang, Logan, Brooks, Dorothy, Cheung, Joshua, Galanter, Hubert, Chen, Divya, Mohan, Melicent C, Peck
Publikováno v:
Critical Care Medicine. 51:103-116
Severe cases of COVID-19 pneumonia can lead to acute respiratory distress syndrome (ARDS). Release of interleukin (IL)-33, an epithelial-derived alarmin, and IL-33/ST2 pathway activation are linked with ARDS development in other viral infections. IL-
Autor:
Frank Wagner, John C Mansfield, Annemarie N Lekkerkerker, Yehong Wang, Mary Keir, Ajit Dash, Brandon Butcher, Brandon Harder, Luz D Orozco, Jordan S Mar, Hao Chen, Michael E Rothenberg
Publikováno v:
Gut. :gutjnl-2022
BackgroundThe interleukin-22 cytokine (IL-22) has demonstrated efficacy in preclinical colitis models with non-immunosuppressive mechanism of action. Efmarodocokin alfa (UTTR1147A) is a fusion protein agonist that links IL-22 to the crystallisable fr
Autor:
Soledad R. Ordonez, Richard A.J. Janssen, Gimano D. Amatngalim, Jamil Aarbiou, Almira Henic, Annemarie N. Lekkerkerker, Maria E. Fuentes, Pieter S. Hiemstra, Renate M. Verhoosel, Jasmijn A. Schrumpf, Henk P. Haagsman, Sriram Sridhar, Esther Dronkers
Publikováno v:
Journal of Innate Immunity, 9(4), 359-374
Antimicrobial proteins and peptides (AMPs) are a central component of the antibacterial activity of airway epithelial cells. It has been proposed that a decrease in antibacterial lung defense contributes to an increased susceptibility to microbial in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4cf31e0327106f6d77a04d2a1c2a54
https://hdl.handle.net/1887/115623
https://hdl.handle.net/1887/115623
Autor:
Renate M. Verhoosel, Yolanda van Wijck, Jürgen Harder, Annemarie N. Lekkerkerker, Pieter S. Hiemstra, Yvonne de Mooij-Eijk, Gimano D. Amatngalim, Richard A.J. Janssen
Publikováno v:
Journal of Immunology, 194(7), 3340-3350
Basal cells play a critical role in the response of the airway epithelium to injury and are recently recognized to also contribute to epithelial immunity. Antimicrobial proteins and peptides are essential effector molecules in this airway epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb8de91c7bbfe950665ecfa56865532
https://doi.org/10.4049/jimmunol.1402169
https://doi.org/10.4049/jimmunol.1402169
Publikováno v:
Current pharmaceutical design. 18(27)
Pathogenic mechanisms involved in fibrosis of various organs share many common features. Myofibroblasts are thought to play a major role in fibrosis through excessive deposition of extracellular matrix during wound healing processes. Myofibroblasts a
Publikováno v:
Lekkerkerker, A N, van Kooyk, Y & Geijtenbeek, T B H 2006, ' Viral piracy : HIV-1 targets dendritic cells for transmission ', Current Pharmaceutical Design, vol. 4, no. 2, pp. 169-76 .
Current HIV research, 4(2), 169-176. Bentham Science Publishers B.V.
Current HIV research, 4(2), 169-176. Bentham Science Publishers B.V.
Dendritic cells (DCs), the professional antigen presenting cells, are critical for host immunity by inducing specific immune responses against a broad variety of pathogens. Remarkably the human immunodeficiency virus-1 (HIV-1) subverts DC function le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3a496b06ce181e1890dfeb2f5874be
https://research.vumc.nl/en/publications/1573772d-572c-4ae2-af50-c37103e991cb
https://research.vumc.nl/en/publications/1573772d-572c-4ae2-af50-c37103e991cb
Publikováno v:
Lekkerkerker, A N, Van Kooyk, Y & Geijtenbeek, T B H 2004, ' Mucosal-targeted AIDS vaccines : the next generation? ', Trends In Microbiology, vol. 12, no. 10, pp. 447-50 . https://doi.org/10.1016/j.tim.2004.08.006
Trends in microbiology, 12(10), 447-450. Elsevier Limited
Trends in microbiology, 12(10), 447-450. Elsevier Limited
Mucosal tissues are the predominant site for human immunodeficiency virus (HIV)-1 infection and replication, and mucosal immunization strategies might be essential to elicit an effective vaccine against acquired immunodeficiency syndrome (AIDS). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cd94dd37727ab8289bcf9a6bf83d5f
https://research.vumc.nl/en/publications/36113712-a1de-4039-85be-2225933c4c80
https://research.vumc.nl/en/publications/36113712-a1de-4039-85be-2225933c4c80