Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Annemarie Larkin"'
Autor:
Annemarie Larkin, Shannon R. Nelson, Chenxi Zhang, Niall Swan, Yonglun Luo, Fiona O'Neill, John Crown, Sandra Roche, Naomi Walsh
Publikováno v:
Scientific Reports
Nelson, S R, Zhang, C, Roche, S, O'Neill, F, Swan, N, Luo, Y, Larkin, A, Crown, J & Walsh, N 2020, ' Modelling of pancreatic cancer biology : transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development ', Scientific Reports, vol. 10, no. 1, 2778 . https://doi.org/10.1038/s41598-020-59368-7
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Nelson, S R, Zhang, C, Roche, S, O'Neill, F, Swan, N, Luo, Y, Larkin, A, Crown, J & Walsh, N 2020, ' Modelling of pancreatic cancer biology : transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development ', Scientific Reports, vol. 10, no. 1, 2778 . https://doi.org/10.1038/s41598-020-59368-7
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
With a five-year survival rate of 9%, pancreatic ductal adenocarcinoma (PDAC) is the deadliest of all cancers. The rapid mortality makes PDAC difficult to research, and inspires a resolve to create reliable, tractable cellular models for preclinical
Autor:
Annemarie Larkin, Sean Doyle, Kieran Walshe, Nicola M. Moloney, Clemens Decristoforo, Holly L. Crean, Linan Xu, Hubertus Haas, David A. Fitzpatrick
Publikováno v:
Analytical Biochemistry. 632:114384
Invasive pulmonary aspergillosis (IPA) is a severe life-threatening condition. Diagnosis of fungal disease in general, and especially that caused by Aspergillus fumigatus is problematic. A. fumigatus secretes siderophores to acquire iron during infec
Autor:
Annemarie Larkin, Michael Henry, Paula Meleady, Peter O'Gorman, Despina Bazou, Martin Clynes, Kay Reen Ting, Justine Meiller, Paul Dowling
Publikováno v:
BBA Clinical
Background Multiple myeloma (MM) is a complex heterogeneous disease. Various risk stratification models have been recommended including cytogenetic and FISH analysis to identify high-risk patients who may benefit from novel treatments, but such facil
Autor:
Paul Dowling, Niall Swan, Brianan McGovern, Paul Barham, Fergal C. Kelleher, Annemarie Larkin, Susan Kennedy, Andrew McCann, Helena Joyce, Jean Murphy, Michael Henry, Michael Moriarty, Martin Clynes, Dermot O’Sullivan, Edel McAuley
Publikováno v:
British Journal of Cancer
Background: Discovery and validation of new antibody tractable targets is critical for the development of new antibody therapeutics to address unmet needs in oncology. Methods: A highly invasive clonal variant of the MDA-MB-435S cell line was used to
Autor:
Annemarie Larkin, Giao Le, Peter O'Gorman, Colin Clarke, Silvia Millán Martín, Jonathan Bones, Stefan Mittermayr
Publikováno v:
Journal of Proteome Research. 16:748-762
The pathological progression from benign monoclonal gammopathy of undetermined significance (MGUS) to smoldering myeloma (SMM) and finally to active myeloma (MM) is poorly understood. Abnormal immunoglobulin G (IgG) glycosylation in myeloma has been
Autor:
Giao Le, Paul Dowling, Peter O'Gorman, Jonathan Bones, Mark R.E. Coyne, Annemarie Larkin, Despina Bazou
Publikováno v:
Molecular omics. 15(1)
Multiple myeloma, an incurable malignancy of the plasma cells in the bone marrow, has a complex pathogenesis due to clonal heterogeneity. Over the years, many clinical trials and researches have led to the development of effective myeloma treatments,
Autor:
Mairin McMenamin, Paul Dowling, Mary Monks, Martin Clynes, Edel McAuley, Annemarie Larkin, Michael Henry, Paula Meleady, Bairbre Wynne, Benvon Moran, Patrick Ormond, Niamh Leonard
Publikováno v:
Oncology Letters
Understanding the events at a protein level that govern the progression from melanoma in situ to invasive melanoma are important areas of current research to be developed. Recent advances in the analysis of formalin-fixed, paraffin-embedded tissue by
Autor:
Martin P. Barr, Emmet O'Brien, Paul Dowling, Damian Pollard, Martin Clynes, Annemarie Larkin, Michael Moriarty, Kathy Gately, Michael Henry, Vincent J. Lynch, Ross K. Morgan, Jo Ballot, Kenneth J. O'Byrne, Paula Meleady, John Crown
Publikováno v:
Molecular BioSystems. 11:743-752
Lung cancer is the second most common type of cancer in the world and is the most common cause of cancer-related death in both men and women. Research into causes, prevention and treatment of lung cancer is ongoing and much progress has been made rec
Autor:
Katrin Friedrich, Martin Clynes, Annett Linge, Gustavo B. Baretton, Annemarie Larkin, Michael Henry, Priyanka Maurya, Shane Kelly, Paula Meleady
Publikováno v:
Journal of Proteome Research. 13:3212-3222
Identification of protein targets that play a role in breast cancer invasion may help to understand the rapid progression of cancer and may lead to the development of new biomarkers for the disease. In this study, we compared two highly invasive and
Autor:
Paul Dowling, Edel Mc Auley, Annemarie Larkin, Helena Joyce, Michael Henry, Paul Barnham, Naomi Walsh, Martin Clynes, Michael Moriarty, Dermot O’Sullivan, Niall Swan
Publikováno v:
Tumor Biology. 35:6983-6997
Development of more effective therapeutic strategies for cancers of high unmet need requires the continued discovery of disease-specific protein targets for therapeutic antibody targeting. In order to identify novel proteins associated with cancer ce