Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis

Autor: Dirkjan van Schaardenburg, Annemarie L. Dorjée, Kulveer Mankia, Xanthe M E Matthijssen, Paul Emery, Laurette van Boheemen, Rachel Knevel, Annette H M van der Helm-van Mil, René E. M. Toes, M. Maurits, M. Verstappen, Fenne Wouters

Publikováno v: Ann Rheum Dis
Annals of the Rheumatic Diseases, 81(1), 48-55. BMJ Publishing Group
Annals of the Rheumatic Diseases, 81(1), 48-55. BMJ PUBLISHING GROUP
Wouters, F, Maurits, M P, Van Boheemen, L, Verstappen, M, Mankia, K, Matthijssen, X M E, Dorjée, A L, Emery, P, Knevel, R, Van Schaardenburg, D, Toes, R E M & Van Der Helm-Van Mil, A H M 2022, ' Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis ', Annals of the Rheumatic Diseases, vol. 81, no. 1, pp. 48-55 . https://doi.org/10.1136/annrheumdis-2021-220546
Annals of the rheumatic diseases, 81(1), 48-55. BMJ Publishing Group

ObjectivesThe human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking are the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). However, at which pre-arthritis stage (asymptomatic/symptomatic) they exert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c740441d21904dd38da4e29dcaa7eec
https://doi.org/10.1136/annrheumdis-2021-220546

FcγRIIB regulates (auto)antibody responses by limiting marginal zone B cell activation

Autor: Ashley N. Barlev, Susan Malkiel, Annemarie L. Dorjée, Jolien Suurmond, Betty Diamond

FcγRIIB is an inhibitory receptor expressed throughout B cell development. Diminished expression or function is associated with lupus in mice and humans, in particular through an effect on autoantibody production and plasma cell differentiation. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8989b87968bb76aac5b5cad0367d30df
https://doi.org/10.1101/2021.12.03.471075

POS0395 ANTI-ACETYLATED PROTEIN ANTIBODIES IN RHEUMATOID ARTHRITIS (RA): CLUES FOR THE STARTING POINT OF AUTOANTIBODY RESPONSES IN RA

Autor: A. Van der Helm van Mil, Twj Huizinga, Annemarie L. Dorjée, D. van der Woude, Rem Toes, T. van Wesemael

Publikováno v: Annals of the Rheumatic Diseases. 80:426.3-427

Background:Rheumatoid arthritis (RA) is characterized by autoantibodies such as rheumatoid factor (RF) and anti-modified protein autoantibodies (AMPAs) like anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein antibodies (anti-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25bd44cfb00ad7a1bb0f73646c8f8564
https://doi.org/10.1136/annrheumdis-2021-eular.2777

Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren's Disease)

Autor: M. Kreulen, Ian M. Clark, Marianna Kruithof-de Julio, Miryam C. Obdeijn, Annemarie L. Dorjée, Peter Kloen, Felice Rivellese, Sofia Karkampouna, Adrian Chojnowski

Publikováno v: Current Molecular Biology Reports
Current molecular biology reports, 2(3), 133-140

Dupuytren’s disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental componen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00827ffa6b085bc4f15e72b99d8a3d6e
https://doi.org/10.1007/s40610-016-0045-3

Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients

Autor: Jeroen DeGroot, Britt Sotthewes, Jeska K de Vries-Bouwstra, Kejie Li, Patrick Cullen, Joanne L. Viney, Agnes Gardet, Jamil Aarbiou, Marc Cheung, S.N. Andersen, Tom W J Huizinga, Timothy S. Zheng, Ellen Cahir-McFarland, David F. Fischer, Annemarie L. Dorjée, Loubna Chadli

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, 9

Systemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique resource to better understand human disease biology, the effect of in vitro culture on thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bf5aa74571f4c6006cf556a8921991
https://pubmed.ncbi.nlm.nih.gov/30872777