Výsledky vyhledávání - "Annemarie H. Becker"

Co-translational mechanisms of protein maturation

Autor: Annemarie H. Becker, Bernd Bukau, Günter Kramer, Felix Gloge

Publikováno v: Current Opinion in Structural Biology. 24:24-33

Protein biogenesis integrates multiple finely regulated mechanisms, ensuring nascent polypeptide chains are correctly enzymatically processed, targeted to membranes and folded to native structure. Recent studies show that the cellular translation mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76711d381048efa7ced477e9bc80ad2
https://doi.org/10.1016/j.sbi.2013.11.004

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Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding

Autor: Anja Hoffmann, Günter Kramer, Annemarie H. Becker, Bernd Bukau, Elke Deuerling, Beate Zachmann-Brand

Publikováno v: Molecular Cell. 48(1):63-74

How nascent polypeptides emerging from ribosomes fold into functional structures is poorly understood. Here, we monitor disulfide bond formation, protease resistance, and enzymatic activity in nascent polypeptides to show that in close proximity to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca3d001bdb2dd29c6b22c341b527ef5

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Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo

Autor: Günter Kramer, Bernd Bukau, Felix Gloge, Arzu Sandikci, Eugene Oh, Robert J. Nichols, Athanasios Typas, Carol A. Gross, Rachna Chaba, Jonathan S. Weissman, Annemarie H. Becker, Damon Huber

Publikováno v: Cell. 147(6):1295-1308

SummaryAs nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting, and folding factors. Here, we present a selective ribosome profiling strategy that enables global monitoring of when these factors engage polypeptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1019139ab9615d020193f2f17aafb994

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Selective ribosome profiling as a tool to study the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes

Autor: Günter Kramer, Annemarie H. Becker, Bernd Bukau, Eugene Oh, Jonathan S. Weissman

A plethora of factors is involved in the maturation of newly synthesized proteins, including chaperones, membrane targeting factors and enzymes. Many factors act co-translationally through association with ribosome-nascent chain complexes (RNCs), but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a466a25d4444b17db9ee9666e9260a97
https://europepmc.org/articles/PMC4001812/

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