Zobrazeno 1 - 10
of 354
pro vyhledávání: '"Annemarie H, Meijer"'
Autor:
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, M. Chiara Fusco, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The emergence of antimicrobial resistance has created an urgent need for alternative treatments against bacterial pathogens. Here, we investigated kinase inhibitors as potential host-directed therapies (HDTs) against intracellular bacteria,
Externí odkaz:
https://doaj.org/article/6fef437e9d004484ab19c1ec22e82119
Autor:
Gül Kilinç, Ralf Boland, Matthias T. Heemskerk, Herman P. Spaink, Mariëlle C. Haks, Michiel van der Vaart, Tom H. M. Ottenhoff, Annemarie H. Meijer, Anno Saris
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Mycobacterium tuberculosis (Mtb) as well as nontuberculous mycobacteria are intracellular pathogens whose treatment is extensive and increasingly impaired due to the rise of mycobacterial drug resistance. The loss of antibiotic efficacy has
Externí odkaz:
https://doaj.org/article/2939a79ee24140a7a75c5c4c4f1addde
Autor:
Ron P. Dirks, Anita Ordas, Susanne Jong-Raadsen, Sebastiaan A. Brittijn, Mariëlle C. Haks, Christiaan V. Henkel, Katarina Oravcova, Peter I. Racz, Nynke Tuinhof-Koelma, Malgorzata I. Korzeniowska nee Wiweger, Stephen H. Gillespie, Annemarie H. Meijer, Tom H. M. Ottenhoff, Hans J. Jansen, Herman P. Spaink
Publikováno v:
Biology, Vol 13, Iss 9, p 688 (2024)
Zebrafish is a natural host of various Mycobacterium species and a surrogate model organism for tuberculosis research. Mycobacterium marinum is evolutionarily one of the closest non-tuberculous species related to M. tuberculosis and shares the majori
Externí odkaz:
https://doaj.org/article/012fc30884164128a2ce1e147383f949
Autor:
Ilona van Alen, Mayra A. Aguirre García, Janneke J. Maaskant, Coenraad P. Kuijl, Wilbert Bitter, Annemarie H. Meijer, Marcellus Ubbink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The β-lactamase of Mycobacterium tuberculosis, BlaC, hydrolyzes β-lactam antibiotics, hindering the use of these antibiotics for the treatment of tuberculosis. Inhibitors, such as avibactam, can reversibly inhibit the enzyme, allowing for
Externí odkaz:
https://doaj.org/article/a12ee8f2c8fe4e89934290ceb65b2da1
Autor:
Robin H. G. A. van den Biggelaar, Kimberley V. Walburg, Susan J. F. van den Eeden, Cassandra L. R. van Doorn, Eugenia Meiler, Alex S. de Ries, Annemarie H. Meijer, Tom H. M. Ottenhoff, Anno Saris
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
The increasing prevalence of antimicrobial-resistant Staphylococcus aureus strains, especially methicillin-resistant S. aureus (MRSA), poses a threat to successful antibiotic treatment. Unsuccessful attempts to develop a vaccine and rising resistance
Externí odkaz:
https://doaj.org/article/d4a0576083104c598b9a431663c54c44
Autor:
Jiajun Xie, Annemarie H. Meijer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Anti-bacterial autophagy, also known as xenophagy, is a crucial innate immune process that helps maintain cellular homeostasis by targeting invading microbes. This defense pathway is widely studied in the context of infections with mycobacteria, the
Externí odkaz:
https://doaj.org/article/91e019a4e76e46c2994b5be1c4651793
Autor:
Samrah Masud, Jiajun Xie, Bart J.M. Grijmans, Sander van der Kooij, Rui Zhang, Tomasz K. Prajsnar, Annemarie H. Meijer
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
DRAM1 is an infection inducible autophagy modulator, previously shown to promote autophagic and lysosomal defense responses against the intracellular pathogen Mycobacterium marinum. However, its possible role in other anti-bacterial autophagic mechan
Externí odkaz:
https://doaj.org/article/b5e9550099de47c6a55374bec8032b0b
Autor:
Ffion R. Hammond, Amy Lewis, Zoë C. Speirs, Holly E. Anderson, Tamara Sipka, Lewis G. Williams, Mai Nguyen-Chi, Annemarie H. Meijer, Geert F. Wiegertjes, Philip M. Elks
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/8ebab5711dd94f1fa690e7a8d37b8c08
Autor:
Ralf Boland, Matthias T. Heemskerk, Gabriel Forn-Cuní, Cornelis J. Korbee, Kimberley V. Walburg, Jeroen J. Esselink, Carina Carvalho dos Santos, Amy M. de Waal, Daniel C. M. van der Hoeven, Elisa van der Sar, Alex S. de Ries, Jiajun Xie, Herman P. Spaink, Michiel van der Vaart, Mariëlle C. Haks, Annemarie H. Meijer, Tom H. M. Ottenhoff
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The global burden of tuberculosis (TB) is aggravated by the continuously increasing emergence of drug resistance, highlighting the need for innovative therapeutic options. The concept of host-directed therapy (HDT) as adjunctive to classical
Externí odkaz:
https://doaj.org/article/b1c54a12efb840389ceb9a3065db7f17
Publikováno v:
Biology, Vol 12, Iss 6, p 817 (2023)
Existing drug treatment against tuberculosis is no match against the increasing number of multi-drug resistant strains of its causative agent, Mycobacterium tuberculosis (Mtb). A better understanding of how mycobacteria subvert the host immune defens
Externí odkaz:
https://doaj.org/article/6630e805fb06483e896d695771dd8e07