Formulation and In Vitro Evaluation of Pellets Containing Sulfasalazine and Caffeine to Verify Ileo-Colonic Drug Delivery

Autor: Annemarie Broesder, Said Y. Bircan, Anneko B. de Waard, Anko C. Eissens, Henderik W. Frijlink, Wouter L. J. Hinrichs

Publikováno v: Pharmaceutics, Vol 13, Iss 12, p 1985 (2021)

The ColoPulse coating is a pH-dependent coating that can be used to target drug release to the ileo-colonic region. ColoPulse coated tablets and capsules have demonstrated their targeting capabilities in vivo in more than 100 volunteers and patients.

Externí odkaz: https://doaj.org/article/01611fb1590542a999a2294bcd6b4735

pH-dependent ileocolonic drug delivery, part I: in vitro and clinical evaluation of novel systems

Autor: Herman J. Woerdenbag, Duong N Nguyen, Annemarie Broesder, Grietje H. Prins, Henderik W. Frijlink, Wouter L. J. Hinrichs

Publikováno v: Drug Discovery Today. 25:1362-1373

After the pH dependency of novel pH-dependent ileocolonic drug delivery systems is confirmed in vitro, their performance should be evaluated in human volunteers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d5e76a63d4e2ecd6d6a4c812e042f1
https://doi.org/10.1016/j.drudis.2020.06.011

Formulation and in vitro evaluation of pellets containing sulfasalazine and caffeine to verify ileo-colonic drug delivery

Autor: Henderik W. Frijlink, Wouter L. J. Hinrichs, Annemarie Broesder, Said Y. Bircan, Anneko B. de Waard, Anko C. Eissens

Publikováno v: Pharmaceutics; Volume 13; Issue 12; Pages: 1985
Pharmaceutics, 13(12):1985. MDPI AG
Pharmaceutics, Vol 13, Iss 1985, p 1985 (2021)
Pharmaceutics

The ColoPulse coating is a pH-dependent coating that can be used to target drug release to the ileo-colonic region. ColoPulse coated tablets and capsules have demonstrated their targeting capabilities in vivo in more than 100 volunteers and patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54025e74196cdd2fbddf08fabbab1c1
https://doi.org/10.3390/pharmaceutics13121985

Polymeric microspheres for the sustained release of a protein-based drug carrier targeting the PDGFβ-receptor in the fibrotic kidney

Autor: Annemarie Broesder, Klaas Poelstra, Peter Olinga, F. van Dijk, Eduard Post, M. Evers, Jan-Luuk Hillebrands, Henderik W. Frijlink, Johan Zuidema, Wouter L. J. Hinrichs, Naomi Teekamp, Rob Steendam, Leonie Beljaars

Publikováno v: International Journal of Pharmaceutics, 534(1-2), 229-236. Elsevier Bedrijfsinformatie b.v.

Injectable sustained release drug delivery systems are an attractive alternative for the intravenous delivery of therapeutic proteins. In particular, for chronic diseases such as fibrosis, this approach could improve therapy by reducing the administr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f267cbced933153c7a7729638dcd58a8
https://research.rug.nl/en/publications/a60ad7df-0cc8-4b96-b869-bdc9f2ef25d2

Formulation of biodegradable microspheres for the sustained release of PDGFβ-receptor directed HSA targeted to fibrotic tissue

Autor: Annemarie Broesder, Naomi Teekamp, Fransien van Dijk, Leonie Beljaars, Wouter Hinrichs, Klaas Poelstra, Frijlink, Henderik W., Peter Olinga

Publikováno v: University of Groningen
11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2362bc8835660fa2933e20f5206110f0
https://research.rug.nl/en/publications/4ac37e86-e0ab-4bd6-ae4d-cdeeeff4e618