Reversal of startle gating deficits in transgenic mice overexpressing corticotropin-releasing factor by antipsychotic drugs

Autor: Lucianne Groenink, Jocelien D A Olivier, Mark A. Geyer, Berend Olivier, Jan van der Gugten, P. Monika Verdouw, Anneloes Dirks, Koen G.C. Westphal

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 28(10), 1790-1798. Nature Publishing Group
Neuropsychopharmacology, 28, 1790-8
Neuropsychopharmacology, 28, 10, pp. 1790-8

Item does not contain fulltext Chronically elevated levels of corticotropin-releasing factor (CRF) in transgenic mice overexpressing CRF in the brain (CRF-OE) appear to be associated with alterations commonly associated with major depressive disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a91438debf7ec6bed2da8e56afe4b75
https://research.rug.nl/en/publications/da45c84b-9d93-4455-ab14-b2a34b752216

Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone

Autor: Lucianne Groenink, Berend Olivier, Marlies Iutje Schipholt, Theo H. Hijzen, Anneloes Dirks, Jan van der Gugten, Mark A. Geyer

Publikováno v: Biological Psychiatry. 51:583-590

Background: Corticotropin-releasing hormone (CRH) hyperactivity in transgenic mice overexpressing CRH in the brain (CRH-OE 2122 ) appears to be associated with chronic stress-like alterations, including increased CRH content in the hypothalamus, chan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7cc329898363d93352c7fa91ee0d75d
https://doi.org/10.1016/s0006-3223(01)01323-3

5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response

Autor: Tommy Pattij, Tatjana T Westphal, Lucianne Groenink, J. Adriaan Bouwknecht, Anneloes Dirks, Jan van der Gugten, Mark A. Geyer, Ronald S. Oosting, Berend Olivier, René Hen, Theo H. Hijzen

Publikováno v: Dirks, A, Pattij, T, Adriaan Bouwknecht, J, Westphal, T T, Hijzen, T H, Groenink, L, Van der Gugten, J, Oosting, R S, Hen, R, Geyer, M A & Olivier, B 2001, ' 5-HT 1B receptor knockout, but not 5-HT 1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response ', Behavioural Brain Research, vol. 118, no. 2, pp. 169-178 . https://doi.org/10.1016/S0166-4328(00)00326-0
Behavioural Brain Research, 118(2), 169-178. Elsevier

To investigate whether the hyperreactivity to mild environmental and novel stimuli in 5-HT1B receptor knockout (1BKO) mice, as suggested by measures of exploratory, aggressive, and impulsive behaviors, can be extended to phasic stimuli, 1BKO and wild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ff95a2fa07196aa67ad10d89c8d44
https://doi.org/10.1016/s0166-4328(00)00326-0

Distress vocalizations in maternally separated mouse pups: modulation via 5-HT 1A , 5-HT 1B and GABA A receptors

Autor: Klaus A. Miczek, Marzenka Sekinda, Eric W. Fish, Pier Francesco Ferrari, Anneloes Dirks

Publikováno v: Psychopharmacology. 149:277-285

Rationale: Young rodents emit ultrasonic vocalizations (USVs) when separated from their dams and littermates. Pharmacological agents that act on GABAA and/or 5-HT receptors and that alleviate anxiety in humans reduce the emission of these calls. Obje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cafd223510a593c3a54ff17bec735a
https://doi.org/10.1007/s002130000370

5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety

Autor: Tommy Pattij, Lucianne Groenink, Reinoud de Jongh, Anneloes Dirks, Ronald S. Oosting, Jan van der Gugten, Berend Olivier

Publikováno v: European Journal of Pharmacology, 463, 1-3, pp. 185-97
Groenink, L, Pattij, T, De Jongh, R, Van Der Gugten, J, Oosting, R S, Dirks, A & Olivier, B 2003, ' 5-HT 1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxiety ', European Journal of Pharmacology, vol. 463, no. 1-3, pp. 185-197 . https://doi.org/10.1016/S0014-2999(03)01281-0
European Journal of Pharmacology, 463, 185-97
European Journal of Pharmacology, 463(1-3), 185-197. Elsevier

Item does not contain fulltext Pharmacological experiments have implicated a role for serotonin (5-HT)(1A) receptors in the modulation of anxiety. More recent is the interest in corticotropin-releasing hormone (CRH) system as a potential target for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e44a70cb0159d99d657b391bda4ed33
https://doi.org/10.1016/S0014-2999(03)01281-0