Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Anneliese O Speak"'
Autor:
Christophe Paget, Shenglou Deng, Daphnée Soulard, David A Priestman, Silvia Speca, Johanna von Gerichten, Anneliese O Speak, Ashish Saroha, Yael Pewzner-Jung, Anthony H Futerman, Thierry Mallevaey, Christelle Faveeuw, Xiaobo Gu, Frances M Platt, Roger Sandhoff, François Trottein
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000169 (2019)
CD1d-restricted invariant natural killer T (iNKT) cells represent a heterogeneous population of lipid-reactive T cells that are involved in many immune responses, mediated through T-cell receptor (TCR)-dependent and/or independent activation. Althoug
Externí odkaz:
https://doaj.org/article/8a14153a2b874fd7bf923e13b9a85947
Autor:
Carmen Ballesteros Reviriego, Simon Clare, Mark J Arends, Emma L Cambridge, Agnieszka Swiatkowska, Susana Caetano, Bushra Abu-Helil, Leanne Kane, Katherine Harcourt, David A Goulding, Diane Gleeson, Edward Ryder, Brendan Doe, Jacqueline K White, Louise van der Weyden, Gordon Dougan, David J Adams, Anneliese O Speak
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212481 (2019)
FBXO7 encodes an F box containing protein that interacts with multiple partners to facilitate numerous cellular processes and has a canonical role as part of an SCF E3 ubiquitin ligase complex. Mutation of FBXO7 is responsible for an early onset Park
Externí odkaz:
https://doaj.org/article/5812179fdf0e4f31ac346c2b3a7e1a3d
Autor:
Natasha A Karp, Anneliese O Speak, Jacqueline K White, David J Adams, Martin Hrabé de Angelis, Yann Hérault, Richard F Mott
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111239 (2014)
A significant challenge facing high-throughput phenotyping of in-vivo knockout mice is ensuring phenotype calls are robust and reliable. Central to this problem is selecting an appropriate statistical analysis that models both the experimental design
Externí odkaz:
https://doaj.org/article/839e38e3d5a64b9ab1371519b18dfa5a
Autor:
Hadi Maazi, Abinav K Singh, Anneliese O Speak, Vincent Lombardi, Jonathan Lam, Bryant Khoo, Kyung Soo Inn, Arlene H Sharpe, Jae U Jung, Omid Akbari
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59599 (2013)
There is evidence indicating that invariant Natural Killer T (iNKT) cells play an important role in defense against influenza A virus (IAV). However, the effect of inhibitory receptor, programmed death-1 (PD-1), and its ligands, programmed death liga
Externí odkaz:
https://doaj.org/article/15a3311e617f4a77807158ecf273ae2d
Autor:
María A. Duque-Correa, David Goulding, Faye H. Rodgers, J. Andrew Gillis, Claire Cormie, Kate A. Rawlinson, Allison J. Bancroft, Hayley M. Bennett, Magda E. Lotkowska, Adam J. Reid, Anneliese O. Speak, Paul Scott, Nicholas Redshaw, Charlotte Tolley, Catherine McCarthy, Cordelia Brandt, Catherine Sharpe, Caroline Ridley, Judit Gali Moya, Claudia M. Carneiro, Tobias Starborg, Kelly S. Hayes, Nancy Holroyd, Mandy Sanders, David J. Thornton, Richard K. Grencis, Matthew Berriman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Whipworms are large parasites causing chronic disease in humans and other mammals. Here, the authors show how larvae create tunnels inside the gut lining and reveal the early host response to infection via Isg15 in mice and murine caecaloids.
Externí odkaz:
https://doaj.org/article/86da51cf01e849638b4d23641665bd5e
Autor:
Oscar C. W. Chen, Alexandria Colaco, Lianne C. Davis, Fedir N. Kiskin, Nicole Y. Farhat, Anneliese O. Speak, David A. Smith, Lauren Morris, Emily Eden, Patricia Tynan, Grant C. Churchill, Antony Galione, Forbes D. Porter, Frances M. Platt
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
Abstract Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified choles
Externí odkaz:
https://doaj.org/article/0e1a6412d2a14de1a7841b940a26ea33
Autor:
Frances M. Platt, David Smith, Lauren Morris, Oscar C. W. Chen, Lianne C. Davis, Alexandria Colaco, Emily R. Eden, Forbes D. Porter, Patricia W. Tynan, Fedir N Kiskin, Anneliese O. Speak, Grant C. Churchill, Nicole Y. Farhat, Antony Galione
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
JIMD Reports
JIMD Reports
Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified cholesterol and
Autor:
Agnes Swiatkowska, David J. Adams, Gemma Turner, Anneliese O. Speak, Louise van der Weyden, Victoria Offord
Publikováno v:
G3: Genes|Genomes|Genetics
Metastasis is the spread of cancer cells to a secondary site within the body, and is the leading cause of death for cancer patients. The lung is a common site of metastasis for many cancer types, including melanoma. Identifying the genes involved in
Autor:
Roy Rabbie, Jyoti S. Choudhary, Vivek Iyer, Victoria Harle, Anneliese O. Speak, Andrew D. Campbell, Louise van der Weyden, Mark Tullett, David J. Adams, Agnieszka Swiatkowska, Gemma Turner, Victoria Offord, Alastair Droop, Owen J. Sansom, Mercedes Pardo, Mark J. Arends, Ingrid Ferreira
Publikováno v:
van der Weyden, L, Harle, V, Turner, G, Offord, V, Iyer, V, Droop, A, Swiatkowska, A, Rabbie, R, Campbell, A D, Sansom, O, Calvo, P, Choudhary, J, Ferreira, I, Tullett, M, Arends, M J, Speak, A O & Adams, D J 2021, ' CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation ', Communications biology . https://doi.org/10.1038/s42003-021-01912-w
Communications biology, 4 (1
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, 4 (1
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Melanoma represents ~5% of all cutaneous malignancies, yet accounts for the majority of skin cancer deaths due to its propensity to metastasise. To develop new therapies, novel target molecules must to be identified and the accessibility of cell surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f837d5f795f2006fde5b535f57805f
https://hdl.handle.net/20.500.11820/b49fb89b-916a-4103-b728-d63fecc4546d
https://hdl.handle.net/20.500.11820/b49fb89b-916a-4103-b728-d63fecc4546d
Autor:
James Hewinson, Marco Ranzani, Victoria Offord, Francesco Iorio, Beiyuan Fu, Vivek Iyer, Anneliese O. Speak, Fengtang Yang, Victoria Harle, Stephen P. Jackson, Martin Del Castillo Velasco-Herrera, Louise van der Weyden, Fiona M. Behan, Mathew J. Garnett, Emanuel Gonçalves, Alastair Droop, Holly Robertson, Guido Zagnoli-Vieira, David J. Adams, Phil Chapman, Elizabeth Anderson, Nicola A. Thompson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Genetic redundancy has evolved as a way for human cells to survive the loss of genes that are single copy and essential in other organisms, but also allows tumours to survive despite having highly rearranged genomes. In this study we CRISPR screen 11