Zobrazeno 1 - 10
of 478
pro vyhledávání: '"Annelies van Rie"'
Autor:
Anzaan Dippenaar, Nabila Ismail, Tim H. Heupink, Melanie Grobbelaar, Johannes Loubser, Annelies Van Rie, Robin M. Warren
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Implementation of whole genome sequencing (WGS) for patient care is hindered by limited Mycobacterium tuberculosis (Mtb) in clinical specimens and slow Mtb growth. We evaluated droplet multiple displacement amplification (dMDA) for amplifica
Externí odkaz:
https://doaj.org/article/bb85ec90990f42c3bc897a1f886ce1b5
Autor:
Christian C. Otum, Emmanuel Rivière, Monique Barnard, Johannes Loubser, Monique J. Williams, Elizabeth M. Streicher, Annelies Van Rie, Robin M. Warren, Marisa Klopper
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Molecular detection of bedaquiline resistant tuberculosis is challenging as only a small proportion of mutations in candidate bedaquiline resistance genes have been statistically associated with phenotypic resistance. We introduced two mutat
Externí odkaz:
https://doaj.org/article/ae71f361f4b04dd4ba76f7495f679496
Autor:
Wakjira Kebede, Gemeda Abebe, Ilke De Boeck, Esayas Kebede Gudina, Eline Cauwenberghs, Sarah Lebeer, Annelies Van Rie
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTIn patients with presumptive tuberculosis (TB) in whom the diagnosis of TB was excluded, understanding the bacterial etiology of lower respiratory tract infections (LRTIs) is important for optimal patient management. A secondary analysis was
Externí odkaz:
https://doaj.org/article/a28cdf08fa714a408be72db84cab2e7e
Autor:
Lennert Verboven, Steven Callens, John Black, Gary Maartens, Kelly E Dooley, Samantha Potgieter, Ruben Cartuyvels, SMARTT team, Kris Laukens, Robin M Warren, Annelies Van Rie
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0306101 (2024)
BackgroundRifampicin resistant tuberculosis remains a global health problem with almost half a million new cases annually. In high-income countries patients empirically start a standardized treatment regimen, followed by an individualized regimen gui
Externí odkaz:
https://doaj.org/article/1179cd02ccde4d34ba148e7d1cd3bf69
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples
Autor:
Tim H. Heupink, Lennert Verboven, Abhinav Sharma, Vincent Rennie, Miguel de Diego Fuertes, Robin M. Warren, Annelies Van Rie
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/341f31dad2b949e1b88155817cd8879f
Autor:
Pham Hien Trang Tu, Degefaye Zelalem Anlay, Anzaan Dippenaar, Emilyn Costa Conceição, Jasna Loos, Annelies Van Rie
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Bedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype from genomic data is not yet possible. A Bayesian method to predict BDQ resistance probabil
Externí odkaz:
https://doaj.org/article/13bff74b96504de396da7ada8ae260be
Autor:
Annelies Van Rie, Elise De Vos, Emilyn Costa, Lennert Verboven, Felex Ndebele, Tim H. Heupink, Steven Abrams, SMARTT team, Boitumelo Fanampe, Anneke Van der Spoel Van Dyk, Salome Charalambous, Gavin Churchyard, Rob Warren
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Rifampicin-resistant tuberculosis (RR-TB) remains an important global health problem. Ideally, the complete drug-resistance profile guides individualized treatment for all RR-TB patients, but this is only practised in high-income
Externí odkaz:
https://doaj.org/article/f5ceb4d6254c47bb83c29ade3dc9634e
Autor:
Nabila Ismail, Anzaan Dippenaar, George Morgan, Melanie Grobbelaar, Felicia Wells, Jessica Caffry, Cristiana Morais, Krzysztof Gizynski, David McGurk, Eduardo Boada, Heather Murton, Robin M. Warren, Annelies Van Rie
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Mycobacterium tuberculosis whole-genome sequencing (WGS) is a powerful tool as it can provide data on population diversity, drug resistance, disease transmission, and mixed infections. Successful WGS is still reliant on high concentrations o
Externí odkaz:
https://doaj.org/article/98ab556599db40239b79132b4ae9e34a
Autor:
Lennert Verboven, Toon Calders, Steven Callens, John Black, Gary Maartens, Kelly E. Dooley, Samantha Potgieter, Robin M. Warren, Kris Laukens, Annelies Van Rie
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Personalized medicine tailors care based on the patient’s or pathogen’s genotypic and phenotypic characteristics. An automated Clinical Decision Support System (CDSS) could help translate the genotypic and phenotypic character
Externí odkaz:
https://doaj.org/article/e9c5a705a93944bba7b196480038f145
Autor:
Lesley Erica Scott, Anne Nicole Shapiro, Manuel Pedro Da Silva, Jonathan Tsoka, Karen Rita Jacobson, Michael Emch, Harry Moultrie, Helen Elizabeth Jenkins, David Moore, Annelies Van Rie, Wendy Susan Stevens
Publikováno v:
Diagnostics, Vol 13, Iss 20, p 3163 (2023)
An investigation was carried out to examine the use of national Xpert MTB/RIF data (2013–2017) and GIS technology for MTB/RIF surveillance in South Africa. The aim was to exhibit the potential of using molecular diagnostics for TB surveillance acro
Externí odkaz:
https://doaj.org/article/80924c23730e464b86fa27f93cd4fdf4