Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Annelies Vennekens"'
Autor:
Emma Laporte, Florian Hermans, Silke De Vriendt, Annelies Vennekens, Diether Lambrechts, Charlotte Nys, Benoit Cox, Hugo Vankelecom
Publikováno v:
eLife, Vol 11 (2022)
The pituitary represents the endocrine master regulator. In mouse, the gland undergoes active maturation immediately after birth. Here, we in detail portrayed the stem cell compartment of neonatal pituitary. Single-cell RNA-sequencing pictured an act
Externí odkaz:
https://doaj.org/article/0efcee480a6f48e3816e78f63c5b172b
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
The pituitary gland has the primordial ability to dynamically adapt its cell composition to changing hormonal needs of the organism throughout life. During the first weeks after birth, an impressive growth and maturation phase is occurring in the gla
Externí odkaz:
https://doaj.org/article/da2337097b314ef8ace11e1964a252d0
Autor:
Charlotte Nys, Patrick Matthys, Adrian Janiszewski, Emma Laporte, Diether Lambrechts, Elodie Modave, Marie-Isabelle Garcia, Hiroto Kobayashi, Benoit Cox, Joel Chappell, Vincent Pasque, Florient Hermans, Hugo Vankelecom, Bert Malengier-Devlies, Annelies Vennekens
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49dd5b500ecf3aa1376b85335bd344f
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/323041
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/323041
Autor:
Benjamin Beck, Hugo Vankelecom, Hiroshi Uji-i, Matteo Boretto, Annelies Vennekens, Emma Laporte, Alizée Vercauteren Drubbel, Indra Van Zundert, Benoit Cox, Heleen Roose, Charlotte Nys, Hiroto Kobayashi
Publikováno v:
Journal of Endocrinology, 240 (2
Journal of Endocrinology
Journal of Endocrinology
The pituitary is the master endocrine gland, harboring stem cells of which the phenotype and role remain poorly characterized. Here, we established organoids from mouse pituitary with the aim to generate a novel research model to study pituitary stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0747a7cb170d10c6a1137c2b68dfa3a
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/303170
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/303170
Publikováno v:
Journal of the Endocrine Society
The pituitary gland harbors a population of stem cells. However, role and regulation of these cells remain poorly understood. We recently established organoids from mouse pituitary as a novel research tool to explore pituitary stem cell biology (Cox
Traumatic brain injury and resultant pituitary dysfunction: insights from experimental animal models
Autor:
Hugo Vankelecom, Annelies Vennekens
Publikováno v:
Pituitary. 22(3)
PURPOSE: Traumatic brain injury (TBI) is a major worldwide cause of disability, often burdening young people with serious lifelong health problems. A frequent clinical complication is post-traumatic hypopituitarism (PTHP) manifesting in several hypot
Autor:
Matteo Boretto, Conny Gysemans, Benoit Cox, Heleen Roose, Annelies Vennekens, Hugo Vankelecom
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2+ cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571a807e41e98db88319ec799fa36b15
https://lirias.kuleuven.be/handle/123456789/604650
https://lirias.kuleuven.be/handle/123456789/604650
Autor:
Heleen, Roose, Benoit, Cox, Matteo, Boretto, Conny, Gysemans, Annelies, Vennekens, Hugo, Vankelecom
Publikováno v:
Scientific Reports
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2+ cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult
Publikováno v:
The Journal of endocrinology. 234(3)
The pituitary gland plays a pivotal role in the endocrine system, steering fundamental processes of growth, metabolism, reproduction and coping with stress. The adult pituitary contains resident stem cells, which are highly quiescent in homeostatic c