Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Annelies Stevaert"'
Autor:
Emiel Vanhulle, Thomas D’huys, Becky Provinciael, Joren Stroobants, Anita Camps, Sam Noppen, Dominique Schols, Els J. M. Van Damme, Piet Maes, Annelies Stevaert, Kurt Vermeire
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Urtica dioica agglutinin (UDA) is a carbohydrate-binding small monomeric protein isolated from stinging nettle rhizomes. It inhibits replication of a broad range of viruses, including coronaviruses, in multiple cell types, with appealing selectivity.
Externí odkaz:
https://doaj.org/article/b8bea83cab5e4494bd4d230d23e683a9
Autor:
Annelies Stevaert, Ria Van Berwaer, Cato Mestdagh, Julie Vandeput, Els Vanstreels, Valerie Raeymaekers, Manon Laporte, Lieve Naesens
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urges better understanding of the functional motifs in the spike (S) protein and their tolerance to mutations. Here, we focused on the S
Externí odkaz:
https://doaj.org/article/c9eb7daf134d4d728bceb84fb8af5508
Autor:
Kelly Bugatti, Andrea Sartori, Lucia Battistini, Crescenzo Coppa, Emiel Vanhulle, Sam Noppen, Becky Provinciael, Lieve Naesens, Annelies Stevaert, Alessandro Contini, Kurt Vermeire, Franca Zanardi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8765 (2023)
Though the bulk of the COVID-19 pandemic is behind, the search for effective and safe anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike (S) protein of SARS-CoV-
Externí odkaz:
https://doaj.org/article/f60413dfa7c94c51ab033a9e6be82aaf
Autor:
Nathalie Vanderheijden, Annelies Stevaert, Jiexiong Xie, Xiaolei Ren, Cyril Barbezange, Sam Noppen, Isabelle Desombere, Bruno Verhasselt, Peter Geldhof, Nick Vereecke, Veerle Stroobants, Dayoung Oh, Merijn Vanhee, Lieve M. J. Naesens, Hans J. Nauwynck
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
To face the continuous emergence of SARS-CoV-2 variants, broadly protective therapeutic antibodies are highly needed. We here focused on the fusion peptide (FP) region of the viral spike antigen since it is highly conserved among alpha- and betacoron
Externí odkaz:
https://doaj.org/article/b6aa29b28bd34fa688c7003f07e0b021
Autor:
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1021 (2022)
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–ac
Externí odkaz:
https://doaj.org/article/d301b0071e384bba936c2d8ac80db4e5
Autor:
Manon Laporte, Valerie Raeymaekers, Ria Van Berwaer, Julie Vandeput, Isabel Marchand-Casas, Hendrik-Jan Thibaut, Dominique Van Looveren, Katleen Martens, Markus Hoffmann, Piet Maes, Stefan Pöhlmann, Lieve Naesens, Annelies Stevaert
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009500 (2021)
The high transmissibility of SARS-CoV-2 is related to abundant replication in the upper airways, which is not observed for the other highly pathogenic coronaviruses SARS-CoV and MERS-CoV. We here reveal features of the coronavirus spike (S) protein,
Externí odkaz:
https://doaj.org/article/2bc3d90380d249a3aa02f9334a1946a2
Autor:
Zsolt Szűcs, Lieve Naesens, Annelies Stevaert, Eszter Ostorházi, Gyula Batta, Pál Herczegh, Anikó Borbás
Publikováno v:
Pharmaceuticals, Vol 13, Iss 7, p 139 (2020)
Influenza A and B viruses are a global threat to human health and increasing resistance to the existing antiviral drugs necessitates new concepts to expand the therapeutic options. Glycopeptide derivatives have emerged as a promising new class of ant
Externí odkaz:
https://doaj.org/article/d2be9f151ae14f04a41f20635e5b57e8
Autor:
Emiel Vanhulle, Jordi Doijen, Joren Stroobants, Becky Provinciael, Sam Noppen, Dominique Schols, Annelies Stevaert, Kurt Vermeire
Publikováno v:
Antiviral Research. 213:105587
Despite the vaccination campaigns for COVID-19, we still cannot control the spread of SARS-CoV-2, as evidenced by the ongoing circulation of the Omicron variants of concern. This highlights the need for broad-spectrum antivirals to further combat COV
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 196:294-299
A new series of N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives were designed, synthesized, and evaluated for their antiviral activity. These new spirothiazolidinone compounds (3a–f, 4a–f) were prepared by a cyclocondensation re
The continuous emergence of new SARS-CoV-2 variants urges better understanding of the functional motifs in the spike (S) protein and their tolerance towards mutations. We here focus on the S2’ motif which, during virus entry, requires cleavage by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63b1a0f38d4f2fef3485634ca924f27
https://doi.org/10.1101/2022.01.26.477969
https://doi.org/10.1101/2022.01.26.477969