Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

Autor: Sytse J. Piersma, Jan W. Drijfhout, Jaap Oostendorp, Margriet J. G. Löwik, Dorien M A Berends-van der Meer, Jeanette M. van der Hulst, Farah Essahsah, Gemma G. Kenter, Peggy J. de Vos van Steenwijk, Sjoerd H. van der Burg, A. Rob P. M. Valentijn, Gert Jan Fleuren, Kees L. M. C. Franken, Lorraine M. Fathers, Annelies P G Vloon, Linda F. M. Stynenbosch, Cornelis J. M. Melief, Tamara H. Ramwadhdoebe, Marij J. P. Welters

Publikováno v: Proceedings of the National Academy of Sciences, 107(26), 11895-11899
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 107(26), 11895-11899. National Academy of Sciences
Welters, M J P, Kenter, G G, van Steenwijk, P J D, Lowik, M J G, Berends-van der Meer, D, Essahsah, F, Stynenbosch, L F M, Vloon, A P G, Ramwadhdoebe, T H, Piersma, S J, van der Hulst, J M, Valentijn, A R P M, Fathers, L M, Drijfhout, J W, Franken, K L M C, Oostendorp, J, Fleuren, G J, Melief, C J M & van der Burg, S H 2010, ' Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses ', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 26, pp. 11895-11899 . https://doi.org/10.1073/pnas.1006500107

One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with r

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http://hdl.handle.net/1887/108376