Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Annelien J.M. Zweemer"'
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Akademický článek
GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment
Autor: Bircan Coban, Zi Wang, Chen-yi Liao, Klara Beslmüller, Mieke A.M. Timmermans, John W.M. Martens, Jasmijn H.M. Hundscheid, Bram Slutter, Annelien J.M. Zweemer, Elsa Neubert, Erik H.J. Danen
Publikováno v: iScience, Vol 27, Iss 5, Pp 109738- (2024)
Summary: Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers NT5E/CD7
Externí odkaz: https://doaj.org/article/7db94f8d0efd4c47abfa7e432f94c9c3
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5
Development of the first potential nonpeptidic positron emission tomography tracer for the imaging of CCR2 receptors
Autor: Nuska Tschammer, Monica De Maria, Daniel G Silva, Michael Koch, Natalia V. Ortiz Zacarías, Fernando de Moura Gatti, Sven Hermann, Anna Junker, Laura H. Heitman, Annelien J.M. Zweemer, Christina Weiss, Klaus Kopka, Dirk Schepmann, Stefan Wagner
Publikováno v: ChemMedChem, 16(4), 640-645
ChemMedChem
ChemMedChem 16(2021)4, 640-645
Chemmedchem
Herein we report the design and synthesis of a series of highly selective CCR2 antagonists as 18F‐labeled PET tracers. The derivatives were evaluated extensively for their off‐target profile at 48 different targets. The most potent and selective
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392db723f0fe9d81b37ab25eabe4f515
http://hdl.handle.net/1887/3134856
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6
Metastasis: crosstalk between tissue mechanics and tumour cell plasticity
Autor: Bircan Coban, Cecilia Bergonzini, Erik H.J. Danen, Annelien J.M. Zweemer
Publikováno v: British Journal of Cancer, 124(1), 49-57. SPRINGERNATURE
British Journal of Cancer
Despite the fact that different genetic programmes drive metastasis of solid tumours, the ultimate outcome is the same: tumour cells are empowered to pass a series of physical hurdles to escape the primary tumour and disseminate to other organs. Epit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a87861cd73bd39e74d998b9c588f768
http://hdl.handle.net/1887/3134840
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7
Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2
Autor: Annelien J.M. Zweemer, Adriaan P. IJzerman, Roy M. Kreekel, Eelke B. Lenselink, Jacobus P. D. van Veldhoven, Natalia V. Ortiz Zacarías, Wijnand J. C. van der Velden, Laura Portner, Laura H. Heitman, Salviana Ullo, Eric van Spronsen, Kenny Oenema, Margo Veenhuizen
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 61(20), 9146-9161. AMER CHEMICAL SOC
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have provided structural evidence for an allosteric, intracellular binding site. The high conservation of residues involved in this site suggests its presence in most che
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bf8903cba6da4ac2be92e68df98b32
https://doi.org/10.1021/acs.jmedchem.8b00605
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8
A two-state model for the kinetics of competitive radioligand binding
Autor: Wesley Keur, Dong Guo, Annelien J.M. Zweemer, Henk de Vries, Laura H. Heitman, Lloyd Bridge, Lambertus A. Peletier, Adriaan P. IJzerman
Publikováno v: British Journal of Pharmacology
Ligand-receptor binding kinetics is receiving increasing attention in the drug research community. The Motulsky and Mahan model, a one-state model, offers a method for measuring the binding kinetics of an unlabelled ligand, with the assumption that t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cc5167810c40719528c11c609fd7fd1
https://doi.org/10.1111/bph.14184
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9
Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells
Autor: Annelien J.M. Zweemer, Joshua M Mesfin, Simon Gordonov, Douglas A. Lauffenburger, Aaron S. Meyer, Cory B. French
Publikováno v: Molecular cancer research : MCR, vol 15, iss 12
PMC
Zweemer, AJM; French, CB; Mesfin, J; Gordonov, S; Meyer, AS; & Lauffenburger, DA. (2017). Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. MOLECULAR CANCER RESEARCH, 15(12), 1656-1666. doi: 10.1158/1541-7786.MCR-17-0012. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0kn785x5
Metastases are a major cause of cancer mortality. AXL, a receptor tyrosine kinase aberrantly expressed in many tumors, is a potent oncogenic driver of metastatic cell motility and has been identified as broadly relevant in cancer drug resistance. Des
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2918406d1cd553d26ac132829954ae05
https://escholarship.org/uc/item/0kn785x5
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10
Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
Autor: Annelien J.M. Zweemer, Christina Weiss, Michael Koch, Anna Junker, Ann Kathrin Strunz, Bernhard Wünsch, Dirk Schepmann, Laura H. Heitman
Publikováno v: Bioorganic & Medicinal Chemistry, 23(14), 4034-4049
Activation of chemokine CC receptors subtype 2 (CCR2) plays an important role in chronic inflammatory processes such as atherosclerosis, multiple sclerosis and rheumatoid arthritis. A diverse set of spirocyclic butanamides 4 (N-benzyl-4-(3,4-dihydros
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48055012558f6e3851c442c81f706f5
https://doi.org/10.1016/j.bmc.2015.02.019
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