Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Anneli Nordqvist"'
Autor:
Amanda J. Kennedy, Linda Sundström, Stefan Geschwindner, Eunice K. Y. Poon, Yuhong Jiang, Rongfeng Chen, Rob Cooke, Shawn Johnstone, Andrew Madin, Junxian Lim, Qingqi Liu, Rink-Jan Lohman, Anneli Nordqvist, Maria Fridén-Saxin, Wenzhen Yang, Dean G. Brown, David P. Fairlie, Niek Dekker
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Kennedy et al. report the pharmacological and in vivo profiling of two small molecule PAR2 inhibitors and an agonist. They conclude that while the small molecule agonist and one of the inhibitors bind to the orthosteric PAR2 binding site, the other i
Externí odkaz:
https://doaj.org/article/e6a39fb1480d47f3b76e5e7e14d4b26c
Autor:
Lauren Drowley, Jane McPheat, Anneli Nordqvist, Samantha Peel, Ulla Karlsson, Sofia Martinsson, Erik Müllers, Anita Dellsén, Sinead Knight, Ian Barrett, José Sánchez, Björn Magnusson, Boris Greber, Qing‐Dong Wang, Alleyn T. Plowright
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 47-60 (2020)
Abstract Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative
Externí odkaz:
https://doaj.org/article/b6628f3b0dc64ed6a5abbc6a43d40735
Autor:
Dean G. Brown, Wenzhen Yang, Rongfeng Chen, Shawn Donald Johnstone, Maria Fridén-Saxin, Stefan Geschwindner, Anneli Nordqvist, Junxian Lim, Linda Sundström, Yuhong Jiang, Qingqi Liu, David P. Fairlie, Rob Cooke, Andrew Madin, Rink-Jan Lohman, Amanda J. Kennedy, Eunice K. Y. Poon, Niek Dekker
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
Protease-activated receptor-2 (PAR2) has been implicated in multiple pathophysiologies but drug discovery is challenging due to low small molecule tractability and a complex activation mechanism. Here we report the pharmacological profiling of a pote
Autor:
Marie-Anne Le Solliec, Julie Maucotel, Aranaud Arabo, Marie Picot, Saloua Takhlidjt, Alexandre Benani, Emmanuelle Nedelec, Anneli Nordqvist, Youssef Anouar, Nicolas Chartrel, Gaëtan Prevost
Publikováno v:
Diabetologia
57. annual meeting of the European-Association-for-the-Study-of-Diabetes (EASD)
57. annual meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2021, Virtual meeting, France. 1 p
HAL
57. annual meeting of the European-Association-for-the-Study-of-Diabetes (EASD)
57. annual meeting of the European-Association-for-the-Study-of-Diabetes (EASD), European Association for the Study of Diabetes (EASD). GBR., Sep 2021, Virtual meeting, France. 1 p
HAL
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fdaa97a368f50b77d8c7627a4912790a
https://hal.inrae.fr/hal-03368831
https://hal.inrae.fr/hal-03368831
Autor:
Kenneth L. Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O’Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson-Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg
Publikováno v:
Journal of Medicinal Chemistry. 62:1385-1406
The mechanism-based risk for hyperkalemia has limited the use of mineralocorticoid receptor antagonists (MRAs) like eplerenone in cardio-renal diseases. Here, we describe the structure and property-driven lead generation and optimization, which resul
Autor:
Anita Dellsén, Jose Miguel Sanchez, Jane McPheat, Sinead Knight, Erik Müllers, Lauren Drowley, Ian P. Barrett, Boris Greber, Samantha Peel, Björn Magnusson, Alleyn T. Plowright, Sofia Martinsson, Qing-Dong Wang, Ulla Karlsson, Anneli Nordqvist
Publikováno v:
Stem Cells Translational Medicine
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 47-60 (2020)
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 47-60 (2020)
Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative therapies
Autor:
Anneli, Nordqvist, Kenneth L, Granberg
Publikováno v:
Vitamins and hormones. 109
Two mineralocorticoid receptor antagonists, spironolactone and eplerenone, are currently approved by the FDA. Several non-steroid based ligands are in clinical trials for indications including heart failure, hypertension and diabetic kidney disease,
Autor:
Nicolas Chartrel, Youssef Anouar, Hervé Lefebvre, Marie-Anne Le Solliec, Jérôme Leprince, Anneli Nordqvist, Gaëtan Prévost, Valéry Brunel, Mouna El Mehdi, Julie Maucotel, Emmanuelle Nédélec, Pierre Déchelotte, Moïse Coëffier, Hind Berrahmoune, Alexandre Benani, Justine Bons, Arnaud Arabo, Saloua Cherifi, Marie Christine Picot
Publikováno v:
American Journal of Physiology. Endocrinology and Metabolism 1 (317), E147-E157. (2019)
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2019, 317 (1), pp.E147-E157. ⟨10.1152/ajpendo.00540.2018⟩
AJP-Endocrinology and Metabolism, 2019, 317 (1), pp.E147-E157. ⟨10.1152/ajpendo.00540.2018⟩
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2019, 317 (1), pp.E147-E157. ⟨10.1152/ajpendo.00540.2018⟩
AJP-Endocrinology and Metabolism, 2019, 317 (1), pp.E147-E157. ⟨10.1152/ajpendo.00540.2018⟩
International audience; Recent studies have shown that the hypothalamic neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin, and increasing insulin sensitivity. In this study, we further characterized the role of the 26RFa/GPR10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dac8e944c7ae29013d01c6fced6bb78
http://prodinra.inra.fr/record/472171
http://prodinra.inra.fr/record/472171
Autor:
Anneli Nordqvist, Kenneth Granberg
Two mineralocorticoid receptor antagonists, spironolactone and eplerenone, are currently approved by the FDA. Several non-steroid based ligands are in clinical trials for indications including heart failure, hypertension and diabetic kidney disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4861f30ae020b66fa5cf00cf371e37e9
https://doi.org/10.1016/bs.vh.2018.10.008
https://doi.org/10.1016/bs.vh.2018.10.008
Autor:
Amalia I. Paunovic, Elke Ericson, Karin Gedda, Anna Jonebring, Anneli Nordqvist, Ola Engkvist, Gunnar Grönberg, Elizabeth Mouchet, Alexander J. Kvist, Martin R. Brown, Qing-Dong Wang, Alleyn T. Plowright, Marie-José Goumans, Lauren Drowley
Publikováno v:
ACS Chemical Biology, 12(1), 132-141
Activation and proliferation of resident cardiac progenitor cells has therapeutic potential to repair the heart after injury. However, research has been impeded by a lack of well-defined and characterized cell sources and difficulties in translation